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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:134870 term browser browse the term
Definition:A racemate consisting of equimolar amounts of (R)- and (S)-toloxatone. It is a reversible monoamine oxidase A inhibitor and antidepressant.
Synonyms:exact_synonym: rac-5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one
 related_synonym: (5RS)-5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one;   (RS)-toloxatone;   Delalande 69276;   Formula=C11H13NO3;   MD-69276;   MD69276;   Perenum;   humoryl;   rac-5-(hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone;   rac-5-hydroxymethyl-3-(m-tolyl)-2-oxazolidinone;   rac-toloxatone;   racemic toloxatone;   toloxatona;   toloxatonum
 xref: CAS:29218-27-7;   DrugBank:DB09245;   Drug_Central:2702;   KEGG:D02559
 xref_mesh: MESH:C010798
 xref: PMID:10371410;   PMID:1221563;   PMID:12659549;   PMID:1352813;   PMID:1424410;   PMID:1546124;   PMID:1546145;   PMID:1705137;   PMID:1843597;   PMID:2353326;   PMID:2365178;   PMID:2768411;   PMID:29844717;   PMID:32935716;   PMID:3634492;   PMID:3810545;   PMID:409416;   PMID:41906;   PMID:494659;   PMID:551645;   PMID:6520180;   PMID:6633672;   PMID:7200786;   PMID:7884022;   PMID:8094790;   PMID:8436164;   Patent:US4699782;   Reaxys:527506;   Wikipedia:Toloxatone

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toloxatone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Maoa monoamine oxidase A decreases activity EXP toloxatone results in decreased activity of MAOA protein CTD PMID:15178694 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      chemical substance 12188
        mixture 11138
          racemate 10070
            toloxatone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                carbocyclic compound 18303
                                  benzenoid aromatic compound 17405
                                    benzenes 17175
                                      toluenes 6241
                                        5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one 1
                                          (R)-toloxatone 1
                                            toloxatone 1
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