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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:134870 term browser browse the term
Definition:A racemate consisting of equimolar amounts of (R)- and (S)-toloxatone. It is a reversible monoamine oxidase A inhibitor and antidepressant.
Synonyms:exact_synonym: rac-5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one
 related_synonym: (5RS)-5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one;   (RS)-toloxatone;   Delalande 69276;   Formula=C11H13NO3;   MD-69276;   MD69276;   Perenum;   humoryl;   rac-5-(hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone;   rac-5-hydroxymethyl-3-(m-tolyl)-2-oxazolidinone;   rac-toloxatone;   racemic toloxatone;   toloxatona;   toloxatonum
 xref: CAS:29218-27-7;   DrugBank:DB09245;   Drug_Central:2702;   KEGG:D02559
 xref_mesh: MESH:C010798
 xref: PMID:10371410;   PMID:1221563;   PMID:12659549;   PMID:1352813;   PMID:1424410;   PMID:1546124;   PMID:1546145;   PMID:1705137;   PMID:1843597;   PMID:2353326;   PMID:2365178;   PMID:2768411;   PMID:29844717;   PMID:32935716;   PMID:3634492;   PMID:3810545;   PMID:409416;   PMID:41906;   PMID:494659;   PMID:551645;   PMID:6520180;   PMID:6633672;   PMID:7200786;   PMID:7884022;   PMID:8094790;   PMID:8436164;   Patent:US4699782;   Reaxys:527506;   Wikipedia:Toloxatone

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toloxatone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Maoa monoamine oxidase A decreases activity EXP toloxatone results in decreased activity of MAOA protein CTD PMID:15178694 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    chemical entity 20071
      chemical substance 13323
        mixture 12473
          racemate 10554
            toloxatone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic molecule 19835
                              organic cyclic compound 19589
                                carbocyclic compound 18528
                                  benzenoid aromatic compound 17772
                                    benzenes 17582
                                      toluenes 7194
                                        5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one 1
                                          (R)-toloxatone 1
                                            toloxatone 1
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