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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:laquinimod
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Accession:CHEBI:134738 term browser browse the term
Synonyms:related_synonym: ABR-215062 sodium;   Formula=C19H17ClN2O3;   InChI=1S/C19H17ClN2O3/c1-3-22(12-8-5-4-6-9-12)19(25)16-17(23)15-13(20)10-7-11-14(15)21(2)18(16)24/h4-11,23H,3H2,1-2H3;   InChIKey=GKWPCEFFIHSJOE-UHFFFAOYSA-N;   SMILES=C1=CC=C(C2=C1N(C(C(=C2O)C(N(C3=CC=CC=C3)CC)=O)=O)C)Cl;   TV-5600;   laquinimod sodium
 xref: CAS:248282-07-7;   Drug_Central:4825
 xref_mesh: MESH:C476223


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laquinimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
affects binding
EXP laquinimod analog results in increased activity of AHR protein
laquinimod analog binds to AHR protein
CTD PMID:28433708, PMID:29908305 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression EXP laquinimod analog results in increased expression of AHRR mRNA CTD PMID:28433708 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
EXP
ISO
laquinimod analog results in increased expression of CYP1A1 mRNA; laquinimod analog results in increased expression of CYP1A1 protein; laquinimod metabolite results in increased expression of CYP1A1 mRNA; laquinimod metabolite results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [laquinimod analog results in increased expression of CYP1A1 protein]
CTD PMID:28433708, PMID:29908305, PMID:32668270 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP laquinimod analog results in increased expression of CYP1A2 mRNA CTD PMID:28433708 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions
EXP
ISO
laquinimod analog results in increased expression of CYP1B1 mRNA; laquinimod metabolite results in increased expression of CYP1B1 mRNA
Progesterone promotes the reaction [laquinimod metabolite results in increased expression of CYP1B1 mRNA]
CTD PMID:28433708, PMID:32668270 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP laquinimod analog results in increased expression of NQO1 mRNA CTD PMID:28433708 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          nitrogen atom 18565
            nitrogen molecular entity 18565
              amide 17416
                aromatic amide 6685
                  laquinimod 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic aromatic compound 19154
                                  aromatic amide 6685
                                    laquinimod 6
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