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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitrosobis(2-oxopropyl)amine
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Accession:CHEBI:134609 term browser browse the term
Definition:A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible).
Synonyms:exact_synonym: N,N-bis(2-oxopropyl)nitrous amide
 related_synonym: 2,2'-dioxo-di-n-propylnitrosamine;   2,2'-dioxopropyl-N-propylnitrosamine;   BOP;   Formula=C6H10N2O3;   InChI=1S/C6H10N2O3/c1-5(9)3-8(7-11)4-6(2)10/h3-4H2,1-2H3;   InChIKey=AKRYBBWYDSDZHG-UHFFFAOYSA-N;   N,N-di(2-oxopropyl)nitrosamine;   N-nitroso-N,N-di(2-oxypropyl)amine;   SMILES=N(N=O)(CC(C)=O)CC(C)=O;   bis-(2-oxopropyl)-N-nitrosamine
 xref: CAS:60599-38-4
 xref_mesh: MESH:C013622
 xref: PMID:17449904;   PMID:17510084;   PMID:18346132;   PMID:19846949;   PMID:21989024;   PMID:22225405;   PMID:22249130;   PMID:26354381;   PMID:26788138;   PMID:857032;   Reaxys:2245698


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nitrosobis(2-oxopropyl)amine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb2 high mobility group box 2 increases expression EXP nitrosobis(2-oxopropyl)amine results in increased expression of HMGB2 protein CTD PMID:29877212 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP nitrosobis(2-oxopropyl)amine results in increased expression of MKI67 protein CTD PMID:29877212 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        aetiopathogenetic role 18963
          carcinogenic agent 18331
            nitrosobis(2-oxopropyl)amine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      ketone 16824
                                        nitrosobis(2-oxopropyl)amine 2
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