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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nitrosobis(2-oxopropyl)amine
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Accession:CHEBI:134609 term browser browse the term
Definition:A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible).
Synonyms:exact_synonym: N,N-bis(2-oxopropyl)nitrous amide
 related_synonym: 2,2'-dioxo-di-n-propylnitrosamine;   2,2'-dioxopropyl-N-propylnitrosamine;   BOP;   Formula=C6H10N2O3;   InChI=1S/C6H10N2O3/c1-5(9)3-8(7-11)4-6(2)10/h3-4H2,1-2H3;   InChIKey=AKRYBBWYDSDZHG-UHFFFAOYSA-N;   N,N-di(2-oxopropyl)nitrosamine;   N-nitroso-N,N-di(2-oxypropyl)amine;   SMILES=N(N=O)(CC(C)=O)CC(C)=O;   bis-(2-oxopropyl)-N-nitrosamine
 xref: CAS:60599-38-4
 xref_mesh: MESH:C013622
 xref: PMID:17449904;   PMID:17510084;   PMID:18346132;   PMID:19846949;   PMID:21989024;   PMID:22225405;   PMID:22249130;   PMID:26354381;   PMID:26788138;   PMID:857032;   Reaxys:2245698


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nitrosobis(2-oxopropyl)amine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb2 high mobility group box 2 increases expression ISO nitrosobis(2-oxopropyl)amine results in increased expression of HMGB2 protein CTD PMID:29877212 NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 increases expression ISO nitrosobis(2-oxopropyl)amine results in increased expression of MKI67 protein CTD PMID:29877212 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        aetiopathogenetic role 21266
          carcinogenic agent 19706
            nitrosobis(2-oxopropyl)amine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbonyl compound 20172
                                    ketone 17949
                                      nitrosobis(2-oxopropyl)amine 2
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