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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nitrosobis(2-oxopropyl)amine
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Accession:CHEBI:134609 term browser browse the term
Definition:A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible).
Synonyms:exact_synonym: N,N-bis(2-oxopropyl)nitrous amide
 related_synonym: 2,2'-dioxo-di-n-propylnitrosamine;   2,2'-dioxopropyl-N-propylnitrosamine;   BOP;   Formula=C6H10N2O3;   InChI=1S/C6H10N2O3/c1-5(9)3-8(7-11)4-6(2)10/h3-4H2,1-2H3;   InChIKey=AKRYBBWYDSDZHG-UHFFFAOYSA-N;   N,N-di(2-oxopropyl)nitrosamine;   N-nitroso-N,N-di(2-oxypropyl)amine;   SMILES=N(N=O)(CC(C)=O)CC(C)=O;   bis-(2-oxopropyl)-N-nitrosamine
 xref: CAS:60599-38-4
 xref_mesh: MESH:C013622
 xref: PMID:17449904;   PMID:17510084;   PMID:18346132;   PMID:19846949;   PMID:21989024;   PMID:22225405;   PMID:22249130;   PMID:26354381;   PMID:26788138;   PMID:857032;   Reaxys:2245698


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nitrosobis(2-oxopropyl)amine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb2 high mobility group box 2 increases expression EXP nitrosobis(2-oxopropyl)amine results in increased expression of HMGB2 protein CTD PMID:29877212 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP nitrosobis(2-oxopropyl)amine results in increased expression of MKI67 protein CTD PMID:29877212 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        aetiopathogenetic role 19267
          carcinogenic agent 18554
            nitrosobis(2-oxopropyl)amine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbonyl compound 18951
                                    ketone 17197
                                      nitrosobis(2-oxopropyl)amine 2
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