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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:toyocamycin
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Accession:CHEBI:134606 term browser browse the term
Definition:An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group.
Synonyms:exact_synonym: 4-amino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
 related_synonym: 4-amino-5-cyano-7-(D-ribofuranosyl)-7H-pyrrolo(2,3-d)pyrimidine;   7-deaza-7-cyanoadenosine;   A-399-Y4;   Ahygroscopin-B;   Antibiotic 1037;   Antibiotic A-399-Y4;   Antibiotic E212;   E-212;   Formula=C12H13N5O4;   InChI=1S/C12H13N5O4/c13-1-5-2-17(11-7(5)10(14)15-4-16-11)12-9(20)8(19)6(3-18)21-12/h2,4,6,8-9,12,18-20H,3H2,(H2,14,15,16)/t6-,8-,9-,12-/m1/s1;   InChIKey=XOKJUSAYZUAMGJ-WOUKDFQISA-N;   SMILES=N1=CN=C2C(=C1N)C(=CN2[C@H]3[C@H](O)[C@H](O)[C@H](O3)CO)C#N;   Siromycin;   Uramycin B;   Vengicide;   cyanotubericidin
 xref: CAS:606-58-6
 xref_mesh: MESH:D014127
 xref: PMID:22629386;   PMID:22852048;   PMID:23775805;   PMID:23900861;   PMID:24057064;   PMID:24509772;   PMID:26790416;   PMID:26969435;   PMID:27912102;   PMID:28058639;   Reaxys:48454



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toyocamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions ISO Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CASP1 protein] CTD PMID:37692514 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL1B protein] CTD PMID:37692514 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 protein] CTD PMID:37692514 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PINK1 protein] CTD PMID:37692514 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of XBP1 protein alternative form] CTD PMID:37692514 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        biochemical role 19589
          antimetabolite 10302
            toyocamycin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19794
                        carbon atom 19790
                          organic molecular entity 19790
                            heteroorganic entity 19548
                              organochalcogen compound 19307
                                organooxygen compound 19223
                                  carbohydrates and carbohydrate derivatives 15297
                                    carbohydrate 15297
                                      carbohydrate derivative 14309
                                        glycosyl compound 13076
                                          N-glycosyl compound 5875
                                            nucleoside 5733
                                              ribonucleoside 1144
                                                toyocamycin 5
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