CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: toyocamycin
Accession: CHEBI:134606
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Definition: An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group.
Synonyms: exact_synonym: 4-amino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
related_synonym: 4-amino-5-cyano-7-(D-ribofuranosyl)-7H-pyrrolo(2,3-d)pyrimidine; 7-deaza-7-cyanoadenosine; A-399-Y4; Ahygroscopin-B; Antibiotic 1037; Antibiotic A-399-Y4; Antibiotic E212; E-212; Formula=C12H13N5O4; InChI=1S/C12H13N5O4/c13-1-5-2-17(11-7(5)10(14)15-4-16-11)12-9(20)8(19)6(3-18)21-12/h2,4,6,8-9,12,18-20H,3H2,(H2,14,15,16)/t6-,8-,9-,12-/m1/s1; InChIKey=XOKJUSAYZUAMGJ-WOUKDFQISA-N; SMILES=N1=CN=C2C(=C1N)C(=CN2[C@H]3[C@H](O)[C@H](O)[C@H](O3)CO)C#N; Siromycin; Uramycin B; Vengicide; cyanotubericidin
xref: CAS:606-58-6
xref_mesh: MESH:D014127
xref: PMID:22629386; PMID:22852048; PMID:23775805; PMID:23900861; PMID:24057064; PMID:24509772; PMID:26790416; PMID:26969435; PMID:27912102; PMID:28058639; Reaxys:48454
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Casp1
caspase 1
multiple interactions
ISO
Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CASP1 protein]
CTD
PMID:37692514
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Il1b
interleukin 1 beta
multiple interactions
ISO
Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL1B protein]
CTD
PMID:37692514
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 protein]
CTD
PMID:37692514
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Pink1
PTEN induced kinase 1
multiple interactions
ISO
Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PINK1 protein]
CTD
PMID:37692514
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
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Xbp1
X-box binding protein 1
multiple interactions
ISO
Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of XBP1 protein alternative form]
CTD
PMID:37692514
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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