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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tertiary amine oxide
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Accession:CHEBI:134363 term browser browse the term
Definition:An N-oxide where there are three organic groups bonded to the nitrogen atom.
Synonyms:related_synonym: Formula=NOR3;   SMILES=*[N+](*)([O-])*;   tertiary amine oxides
 xref: Patent:EP0545208;   Patent:EP0757983;   Patent:EP0866058;   Patent:EP1068179;   Patent:US4206204;   Patent:WO9950236


show annotations for term's descendants           Sort by:
 
Ammothamnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP oxymatrine inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein] CTD PMID:27713174 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of CREBBP mRNA] CTD PMID:18395914 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP oxymatrine inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA] CTD PMID:23568217 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:15603720 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP oxymatrine promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein] CTD PMID:27713174 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in decreased expression of IFNG protein] CTD PMID:15603720 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL10 protein] CTD PMID:15603720 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO oxymatrine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA] CTD PMID:23568217 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2 protein] CTD PMID:15603720 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
oxymatrine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:23568217 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
increases expression
ISO oxymatrine inhibits the reaction [arsenic trioxide results in decreased localization of KCNH2 protein]
oxymatrine results in increased expression of KCNH2 protein
CTD PMID:23103450 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP oxymatrine promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 protein] CTD PMID:27713174 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP oxymatrine inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:23568217 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:18395914 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad7 SMAD family member 7 increases expression ISO oxymatrine results in increased expression of SMAD7 mRNA CTD PMID:18395914 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:18395914 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:15633229 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:15603720, PMID:23568217 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
trimethylamine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein] CTD PMID:25568320 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Casp3 caspase 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein] CTD PMID:25568320 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein] CTD PMID:25568320 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Mbp myelin basic protein multiple interactions ISO trimethyloxamine promotes the reaction [MBP protein binds to MBP protein]; trimethyloxamine promotes the reaction [MBP protein mutant form binds to MBP protein mutant form] CTD PMID:12372316 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases reduction
ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine; NAD affects the reaction [MTARC1 protein results in increased reduction of trimethyloxamine] CTD PMID:29856598 NCBI chr13:102,693,679...102,724,120
Ensembl chr13:102,698,546...102,721,218
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethyloxamine CTD PMID:21561886 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP trimethyloxamine promotes the reaction [rimabotulinumtoxinB results in increased cleavage of VAMP2 protein modified form] CTD PMID:27032463 NCBI chr10:55,675,171...55,679,405
Ensembl chr10:55,675,575...55,679,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      molecular entity 19814
        polyatomic entity 19727
          heteroatomic molecular entity 19653
            oxide 11630
              N-oxide 113
                tertiary amine oxide 25
                  (-)-Alstolucine C 0
                  (1S)-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-2-oxido-3,4-dihydro-1H-isoquinolin-2-ium-7-ol 0
                  1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide 0
                  19(E)-18-Demethoxygardfloramine-N(4)-oxide 0
                  3-(2-chloro-10-oxido-10-phenothiazin-10-iumyl)-N,N-dimethyl-1-propanamine 0
                  Ammothamnine 18
                  Epimauritine A N-oxide 0
                  Gardfloramine-N(4)-oxide 0
                  LSM-1606 0
                  LSM-5030 0
                  Mauritine A N-oxide 0
                  Minfiensine-N(4)-oxide 0
                  Morphine N-oxide 0
                  N,N-dimethylaniline N-oxide 0
                  Oxystemokerrine N-oxide 0
                  acetylerucifoline N-oxide 0
                  acetylseneciphylline N-oxide 0
                  chlorpromazine N-oxide 0
                  decylamine-N,N-dimethyl-N-oxide 0
                  dodecyldimethylamine N-oxide 0
                  erucifoline N-oxide 0
                  gardneramine-N(4)-oxide 0
                  isobrucine N-oxide 0
                  isostrychnine N-oxide 0
                  jacobine N-oxide 0
                  jacoline N-oxide 0
                  jaconine N-oxide 0
                  jacozine N-oxide 0
                  nupharidine 0
                  piperidine N-oxide + 0
                  pyrrolidine N-oxides + 0
                  riddelliine N-oxide 0
                  senecionine N-oxide 0
                  seneciphylline N-oxide 0
                  senecivernine N-oxide 0
                  spartioidine N-oxide 0
                  stemocurtisine N-oxide 0
                  strychnine N-oxide 0
                  symphytine oxide 0
                  tamoxifen N-oxide 0
                  trans-4-(dimethylphenylsilyl)-N-methylpiperidine N-oxide 0
                  trimethylamine N-oxide 7
                  usaramine N-oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        tertiary amino compound 8643
                                          tertiary amine oxide 25
                                            (-)-Alstolucine C 0
                                            (1S)-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-2-oxido-3,4-dihydro-1H-isoquinolin-2-ium-7-ol 0
                                            1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide 0
                                            19(E)-18-Demethoxygardfloramine-N(4)-oxide 0
                                            3-(2-chloro-10-oxido-10-phenothiazin-10-iumyl)-N,N-dimethyl-1-propanamine 0
                                            Ammothamnine 18
                                            Epimauritine A N-oxide 0
                                            Gardfloramine-N(4)-oxide 0
                                            LSM-1606 0
                                            LSM-5030 0
                                            Mauritine A N-oxide 0
                                            Minfiensine-N(4)-oxide 0
                                            Morphine N-oxide 0
                                            N,N-dimethylaniline N-oxide 0
                                            Oxystemokerrine N-oxide 0
                                            acetylerucifoline N-oxide 0
                                            acetylseneciphylline N-oxide 0
                                            chlorpromazine N-oxide 0
                                            decylamine-N,N-dimethyl-N-oxide 0
                                            dodecyldimethylamine N-oxide 0
                                            erucifoline N-oxide 0
                                            gardneramine-N(4)-oxide 0
                                            isobrucine N-oxide 0
                                            isostrychnine N-oxide 0
                                            jacobine N-oxide 0
                                            jacoline N-oxide 0
                                            jaconine N-oxide 0
                                            jacozine N-oxide 0
                                            nupharidine 0
                                            piperidine N-oxide + 0
                                            pyrrolidine N-oxides + 0
                                            riddelliine N-oxide 0
                                            senecionine N-oxide 0
                                            seneciphylline N-oxide 0
                                            senecivernine N-oxide 0
                                            spartioidine N-oxide 0
                                            stemocurtisine N-oxide 0
                                            strychnine N-oxide 0
                                            symphytine oxide 0
                                            tamoxifen N-oxide 0
                                            trans-4-(dimethylphenylsilyl)-N-methylpiperidine N-oxide 0
                                            trimethylamine N-oxide 7
                                            usaramine N-oxide 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.