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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP ISO |
salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of ACTA2 protein]; salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of ACTA2 protein]]; salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased expression of ACTA2 protein] |
CTD |
PMID:19822164 PMID:33290806 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:22545124 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; salvianolic acid B inhibits the reaction [Cisplatin results in increased expression of BAX protein]; salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of BAX protein] |
CTD |
PMID:23201927 PMID:28495616 PMID:33952797 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [arsenic trioxide results in decreased expression of BCL2 protein]]; salvianolic acid B inhibits the reaction [arsenic trioxide results in decreased expression of BCL2 protein]; salvianolic acid B inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] salvianolic acid B results in increased expression of BCL2 protein |
CTD |
PMID:23201927 PMID:28495616 |
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NCBI chr13:22,689,783...22,853,920
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions increases expression |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]]; salvianolic acid B inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]; salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of BCL2L1 protein] salvianolic acid B results in increased expression of BCL2L1 protein |
CTD |
PMID:23201927 PMID:24769256 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bdnf |
brain-derived neurotrophic factor |
increases expression multiple interactions |
ISO |
salvianolic acid B results in increased expression of BDNF protein salvianolic acid B inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF protein] |
CTD |
PMID:24991814 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]]; salvianolic acid B inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; salvianolic acid B inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; salvianolic acid B inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein] |
CTD |
PMID:23201927 PMID:24769256 PMID:28495616 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
salvianolic acid B inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]; salvianolic acid B inhibits the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]] salvianolic acid B affects the reaction [TGFB1 protein affects the reaction [SMAD3 protein mutant form affects the expression of CDKN1A protein]] |
CTD |
PMID:33290806 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] |
CTD |
PMID:19474275 |
|
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Crp |
C-reactive protein |
multiple interactions decreases expression |
EXP ISO |
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of CRP mRNA]; salvianolic acid B inhibits the reaction [Ethanol results in increased expression of CRP protein] salvianolic acid B inhibits the reaction [Ethanol results in increased expression of CRP protein]; SIRT1 protein affects the reaction [salvianolic acid B results in decreased expression of CRP protein] |
CTD |
PMID:27989594 |
|
NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
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G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of CYBB protein]; salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of CYBB protein] |
CTD |
PMID:19822164 |
|
NCBI chr X:13,360,583...13,392,517
Ensembl chr X:13,359,430...13,392,586
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein] |
CTD |
PMID:27989594 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of DDIT3 protein] |
CTD |
PMID:28495616 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Gdnf |
glial cell derived neurotrophic factor |
increases expression multiple interactions increases secretion |
ISO |
salvianolic acid B results in increased expression of GDNF mRNA NFE2L2 protein affects the reaction [salvianolic acid B results in increased expression of GDNF mRNA]; NFE2L2 protein affects the reaction [salvianolic acid B results in increased secretion of GDNF protein] |
CTD |
PMID:24991814 |
|
NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP ISO |
salvianolic acid B inhibits the reaction [Ethanol results in increased activity of GPT protein]; salvianolic acid B inhibits the reaction [Ethanol results in increased expression of GPT protein] salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of GPT protein]]; salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein] |
CTD |
PMID:24769256 PMID:27989594 PMID:33290806 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of GSTP1 protein]] |
CTD |
PMID:33290806 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP ISO |
salvianolic acid B inhibits the reaction [Cisplatin results in decreased expression of HMOX1 mRNA] |
CTD |
PMID:33952797 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnf1a |
HNF1 homeobox A |
multiple interactions |
ISO |
salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of HNF1A protein] |
CTD |
PMID:27989594 |
|
NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein] |
CTD |
PMID:28495616 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP ISO |
salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of IL1B protein] NFE2L2 protein affects the reaction [salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:19822164 PMID:24991814 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of IL6 protein]; salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] |
CTD |
PMID:19822164 PMID:24769256 PMID:27989594 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mlxipl |
MLX interacting protein-like |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL mRNA]; salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL protein]; SIRT1 protein affects the reaction [salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL protein]] |
CTD |
PMID:27989594 |
|
NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]; salvianolic acid B inhibits the reaction [SMAD3 protein mutant form affects the reaction [Diethylnitrosamine results in increased expression of MYC protein]]; SMAD3 protein modified form affects the reaction [salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]] |
CTD |
PMID:33290806 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of NCF1 protein] |
CTD |
PMID:19822164 |
|
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
ISO EXP |
NFE2L2 protein affects the reaction [salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; NFE2L2 protein affects the reaction [salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; NFE2L2 protein affects the reaction [salvianolic acid B results in increased expression of GDNF mRNA]; NFE2L2 protein affects the reaction [salvianolic acid B results in increased secretion of GDNF protein]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]; salvianolic acid B inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein]; salvianolic acid B results in increased secretion of and affects the localization of NFE2L2 protein salvianolic acid B results in increased expression of NFE2L2 protein |
CTD |
PMID:24991814 PMID:33952797 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein] |
CTD |
PMID:19822164 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO EXP |
salvianolic acid B inhibits the reaction [Cisplatin results in decreased expression of NQO1 mRNA] |
CTD |
PMID:33952797 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [PDGFB protein results in increased abundance of Hydrogen Peroxide]; salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of ACTA2 protein]; salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of CYBB protein]; salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of NCF1 protein] |
CTD |
PMID:19822164 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Ethanol results in increased acetylation of PPARGC1A protein] |
CTD |
PMID:24769256 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
salvianolic acid B affects the reaction [Diethylnitrosamine affects the expression of SERPINE1 protein]; salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine affects the expression of SERPINE1 protein]]; salvianolic acid B affects the reaction [SMAD3 protein mutant form affects the reaction [Diethylnitrosamine affects the expression of SERPINE1 protein]] |
CTD |
PMID:33290806 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Sirt1 |
sirtuin 1 |
increases expression multiple interactions |
ISO EXP |
salvianolic acid B results in increased expression of SIRT1 protein salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL protein]] salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [salvianolic acid B results in decreased expression of CRP protein] |
CTD |
PMID:24769256 PMID:27989594 |
|
NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
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G |
Smad3 |
SMAD family member 3 |
multiple interactions affects response to substance |
ISO |
salvianolic acid B affects the reaction [Diethylnitrosamine results in decreased expression of SMAD3 protein modified form]; salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine affects the expression of SERPINE1 protein]]; salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of ACTA2 protein]]; salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of GPT protein]]; salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of GSTP1 protein]]; salvianolic acid B affects the reaction [SMAD3 protein mutant form affects the reaction [Diethylnitrosamine affects the expression of SERPINE1 protein]]; salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of SMAD3 protein]; salvianolic acid B inhibits the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]]; salvianolic acid B inhibits the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in decreased expression of SMAD3 protein modified form]]; salvianolic acid B inhibits the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased phosphorylation of SMAD3 protein]]; salvianolic acid B inhibits the reaction [SMAD3 protein mutant form affects the reaction [Diethylnitrosamine results in increased expression of MYC protein]]; SMAD3 protein modified form affects the reaction [salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]] salvianolic acid B affects the reaction [TGFB1 protein affects the reaction [SMAD3 protein mutant form affects the expression of CDKN1A protein]] SMAD3 protein modified form affects the susceptibility to salvianolic acid B |
CTD |
PMID:33290806 |
|
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of SOD2 protein] |
CTD |
PMID:24769256 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP ISO |
salvianolic acid B inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 protein]; salvianolic acid B inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] salvianolic acid B affects the reaction [TGFB1 protein affects the reaction [SMAD3 protein mutant form affects the expression of CDKN1A protein]] |
CTD |
PMID:16009107 PMID:19474275 PMID:33290806 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgfbr1 |
transforming growth factor, beta receptor 1 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFBR1 protein] |
CTD |
PMID:16009107 |
|
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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G |
Tgfbr2 |
transforming growth factor, beta receptor 2 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFBR2 protein] |
CTD |
PMID:16009107 |
|
NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] |
CTD |
PMID:22101700 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of TNF protein]; salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of TNF protein] NFE2L2 protein affects the reaction [salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:19822164 PMID:22101700 PMID:24769256 PMID:24991814 PMID:27989594 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
decreases acetylation multiple interactions |
ISO EXP |
salvianolic acid B results in decreased acetylation of TP53 protein salvianolic acid B inhibits the reaction [Ethanol results in increased acetylation of TP53 protein] |
CTD |
PMID:24769256 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Trpc3 |
transient receptor potential cation channel, subfamily C, member 3 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of TRPC3 protein] |
CTD |
PMID:28495616 |
|
NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855
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G |
Trpc6 |
transient receptor potential cation channel, subfamily C, member 6 |
multiple interactions |
EXP |
salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of TRPC6 protein] |
CTD |
PMID:28495616 |
|
NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
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