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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha-(methylamino)isobutyric acid
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Accession:CHEBI:134261 term browser browse the term
Definition:A non-proteinogenic alpha-amino acid that is isobutyric acid in which the alpha-hydrogen has been replaced by a methylamino group.
Synonyms:exact_synonym: N,2-dimethylalanine
 related_synonym: 2-(Methylamino)isobutyric acid;   Formula=C5H11NO2;   InChI=1S/C5H11NO2/c1-5(2,6-3)4(7)8/h6H,1-3H3,(H,7,8);   InChIKey=DLAMVQGYEVKIRE-UHFFFAOYSA-N;   SMILES=OC(=O)C(NC)(C)C
 xref: CAS:2566-34-9;   Chemspider:68242
 xref_mesh: MESH:C017911
 xref: PMID:15243140;   PMID:15774260;   PMID:16202926;   PMID:16373326;   PMID:17003038;   PMID:17050538;   PMID:17504964;   PMID:21055620;   PMID:26346312;   PMID:8338132;   Reaxys:1746984
 cyclic_relationship: is_conjugate_acid_of CHEBI:192077



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alpha-(methylamino)isobutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA] CTD PMID:22215663 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of HSPA5 mRNA] CTD PMID:22215663 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Igf1 insulin-like growth factor 1 increases uptake
multiple interactions
EXP IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid
oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]
CTD PMID:1928324 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein] CTD PMID:22215663 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO SLC38A2 mutant form inhibits the reaction [arsenite results in increased transport of 2-(methylamino)isobutyric acid] CTD PMID:22215663 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20026
      biological role 20025
        biochemical role 19665
          volatile oil component 6974
            isobutyric acid 3103
              alpha-(methylamino)isobutyric acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    p-block element atom 19974
                      carbon group element atom 19903
                        carbon atom 19896
                          organic molecular entity 19896
                            organic group 18994
                              organic divalent group 18980
                                organodiyl group 18980
                                  carbonyl group 18933
                                    carbonyl compound 18933
                                      carboxylic acid 18629
                                        monocarboxylic acid 17867
                                          fatty acid 16492
                                            saturated fatty acid 16151
                                              propionic acid 3762
                                                alanine 109
                                                  alanine derivative 107
                                                    alpha-(methylamino)isobutyric acid 5
paths to the root