CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: alpha-(methylamino)isobutyric acid
Accession: CHEBI:134261
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Definition: A non-proteinogenic alpha-amino acid that is isobutyric acid in which the alpha-hydrogen has been replaced by a methylamino group.
Synonyms: exact_synonym: N,2-dimethylalanine
related_synonym: 2-(Methylamino)isobutyric acid; Formula=C5H11NO2; InChI=1S/C5H11NO2/c1-5(2,6-3)4(7)8/h6H,1-3H3,(H,7,8); InChIKey=DLAMVQGYEVKIRE-UHFFFAOYSA-N; SMILES=OC(=O)C(NC)(C)C
xref: CAS:2566-34-9; Chemspider:68242
xref_mesh: MESH:C017911
xref: PMID:15243140; PMID:15774260; PMID:16202926; PMID:16373326; PMID:17003038; PMID:17050538; PMID:17504964; PMID:21055620; PMID:26346312; PMID:8338132; Reaxys:1746984
cyclic_relationship: is_conjugate_acid_of CHEBI:192077
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Ddit3
DNA-damage inducible transcript 3
multiple interactions
ISO
2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA]
CTD
PMID:22215663
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Hspa5
heat shock protein family A (Hsp70) member 5
multiple interactions
ISO
2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of HSPA5 mRNA]
CTD
PMID:22215663
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Igf1
insulin-like growth factor 1
increases uptake multiple interactions
EXP
IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]
CTD
PMID:1928324
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Rps6kb1
ribosomal protein S6 kinase B1
multiple interactions
ISO
2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]
CTD
PMID:22215663
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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Slc38a2
solute carrier family 38, member 2
multiple interactions
ISO
SLC38A2 mutant form inhibits the reaction [arsenite results in increased transport of 2-(methylamino)isobutyric acid]
CTD
PMID:22215663
NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
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