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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:muricholic acids
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Accession:CHEBI:134216 term browser browse the term
Definition:A group of trihydroxy-5beta-cholanic acids that are the 6,7-diastereoisomers of 3alpha,6,7-trihydroxy-5beta-cholan-24-oic acid.
Synonyms:related_synonym: Formula=C24H40O5;   InChI=1S/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13-,14-,15-,16+,17+,18+,20+,21?,22?,23-,24-/m1/s1;   InChIKey=DKPMWHFRUGMUKF-JDDNAIEOSA-N;   SMILES=C1[C@H](C[C@@]2([C@](C1)([C@@]3([C@@](C(C2O)O)([C@@]4([H])[C@@](CC3)(C)[C@](CC4)([C@@H](CCC(O)=O)C)[H])[H])[H])C)[H])O
 xref: HMDB:HMDB0000865;   Wikipedia:Muricholic_acid

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tauro-beta-muricholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 increases expression
multiple interactions		 ISO tauromuricholic acid results in increased expression of ABCB11 protein
tauromuricholic acid results in increased expression of and results in increased activity of ABCB11 protein		 CTD PMID:11672435 PMID:12644037 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 increases expression
multiple interactions		 ISO tauromuricholic acid results in increased expression of ABCC2 protein
tauromuricholic acid results in increased expression of and results in increased activity of ABCC2 protein		 CTD PMID:11672435 PMID:12644037 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 increases expression ISO tauromuricholic acid results in increased expression of ABCC3 protein CTD PMID:11672435 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997 		JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases abundance
increases secretion		 EXP AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin affects the secretion of tauromuricholic acid]
AHR gene mutant form results in increased abundance of tauromuricholic acid
AHR gene mutant form results in increased secretion of tauromuricholic acid		 CTD PMID:29452137 PMID:32679164 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038 		JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 multiple interactions EXP [Taurocholic Acid co-treated with muricholic acid co-treated with tauromuricholic acid] results in increased expression of CXCL2 mRNA CTD PMID:22098667 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938 		JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 multiple interactions EXP [Taurocholic Acid co-treated with muricholic acid co-treated with tauromuricholic acid] results in increased expression of CXCL1 mRNA CTD PMID:22098667 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600 		JBrowse link
G Fech ferrochelatase affects abundance EXP FECH protein affects the abundance of tauromuricholic acid CTD PMID:29906468 NCBI chr18:64,456,542...64,489,098
Ensembl chr18:64,452,914...64,490,251 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP [Taurocholic Acid co-treated with muricholic acid co-treated with tauromuricholic acid] results in increased expression of ICAM1 mRNA CTD PMID:22098667 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817 		JBrowse link
G Il10 interleukin 10 increases abundance EXP IL10 gene mutant form results in increased abundance of tauromuricholic acid CTD PMID:27580383 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 affects abundance EXP NR1H4 protein affects the abundance of tauromuricholic acid CTD PMID:30556042 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases abundance		 EXP [PPARA gene mutant form results in increased susceptibility to Clofibrate] which results in increased abundance of tauromuricholic acid; PPARA gene mutant form inhibits the reaction [Gemfibrozil results in increased abundance of tauromuricholic acid]
PPARA gene mutant form results in increased abundance of tauromuricholic acid		 CTD PMID:24385052 PMID:29175453 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819 		JBrowse link
G Slc10a2 solute carrier family 10, member 2 increases expression ISO tauromuricholic acid results in increased expression of SLC10A2 protein CTD PMID:11672435 NCBI chr 8:5,083,219...5,105,287
Ensembl chr 8:5,083,219...5,105,351 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 affects abundance EXP SLCO1A1 protein affects the abundance of tauromuricholic acid CTD PMID:21914718 NCBI chr 6:141,907,281...141,946,962
Ensembl chr 6:141,907,282...141,946,962 		JBrowse link
G Smad3 SMAD family member 3 increases abundance EXP SMAD3 protein results in increased abundance of tauromuricholic acid CTD PMID:23034213 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21560
    chemical entity 21558
      molecular entity 21543
        polyatomic entity 21417
          heteroatomic molecular entity 21343
            hydroxides 20127
              organic hydroxy compound 19142
                hydroxy-5beta-cholanic acid 929
                  trihydroxy-5beta-cholanic acid 257
                    muricholic acids 14
                      alpha-muricholic acid 0
                      beta-muricholic acid + 14
                      hyocholic acid + 0
                      omega-muricholic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21560
    subatomic particle 21546
      composite particle 21546
        hadron 21546
          baryon 21546
            nucleon 21546
              atomic nucleus 21546
                atom 21546
                  main group element atom 21449
                    p-block element atom 21449
                      carbon group element atom 21240
                        carbon atom 21135
                          organic molecular entity 21135
                            organic molecule 21027
                              organic cyclic compound 20576
                                organic polycyclic compound 17206
                                  steroid 13054
                                    steroid fundamental parent 12663
                                      cholane 945
                                        cholanoid 945
                                          cholanic acids 929
                                            cholanic acid 929
                                              5beta-cholanic acid 929
                                                hydroxy-5beta-cholanic acid 929
                                                  trihydroxy-5beta-cholanic acid 257
                                                    muricholic acids 14
                                                      alpha-muricholic acid 0
                                                      beta-muricholic acid + 14
                                                      hyocholic acid + 0
                                                      omega-muricholic acid 0
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