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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:capsiate
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Accession:CHEBI:134190 term browser browse the term
Definition:A carboxylic ester obtained by formal condensation of the carboxy group of (6E)-8-methylnon-6-enoic acid with the benzylic hydroxy group of vanillyl alcohol. A non-pungent analogue of capsaicin with a similar biological profile.
Synonyms:exact_synonym: (4-hydroxy-3-methoxyphenyl)methyl (6E)-8-methylnon-6-enoate
 related_synonym: Formula=C18H26O4;   InChI=1S/C18H26O4/c1-14(2)8-6-4-5-7-9-18(20)22-13-15-10-11-16(19)17(12-15)21-3/h6,8,10-12,14,19H,4-5,7,9,13H2,1-3H3/b8-6+;   InChIKey=ZICNYIDDNJYKCP-SOFGYWHQSA-N;   SMILES=CC(C)\\C=C\\CCCCC(=O)OCC=1C=CC(=C(C1)OC)O;   vanillyl (6E)-8-methylnon-6-enoate
 xref: AGR:IND44385191;   CAS:205687-01-0;   Chemspider:8015237;   HMDB:HMDB0034780;   KEGG:C20203
 xref_mesh: MESH:C470213
 xref: PMID:12726827;   PMID:12959953;   PMID:16636441;   PMID:17264228;   PMID:17971242;   PMID:18172315;   PMID:19773740;   PMID:20102390;   PMID:20123015;   PMID:21071592;   PMID:21878735;   PMID:21883144;   PMID:21928164;   PMID:22038945;   PMID:23026494;   PMID:24026939;   PMID:24102723;   PMID:24644244;   PMID:25806854;   PMID:26030806;   PMID:28001433;   PMID:28230360;   PMID:28569248;   Reaxys:7933697


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capsiate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 Cd69 molecule decreases localization ISO capsiate analog results in decreased localization of CD69 protein CTD PMID:12115659 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases localization ISO capsiate analog results in decreased localization of ICAM1 protein CTD PMID:12115659 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO capsiate results in increased expression of IGF1 protein CTD PMID:17307377 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions ISO capsiate analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased activity of IKBKG protein] CTD PMID:12115659 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases localization ISO capsiate analog results in decreased localization of IL2RA protein CTD PMID:12115659 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO capsiate analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased degradation of NFKBIA protein] CTD PMID:12115659 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ucp3 uncoupling protein 3 decreases expression EXP capsiate results in decreased expression of UCP3 mRNA CTD PMID:17264228 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      chemical role 19497
        antioxidant 16054
          capsiate 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    p-block element atom 19845
                      carbon group element atom 19792
                        carbon atom 19787
                          organic molecular entity 19787
                            organic molecule 19744
                              organic cyclic compound 19549
                                carbocyclic compound 18596
                                  benzenoid aromatic compound 17956
                                    benzenes 17806
                                      methoxybenzenes 2046
                                        monomethoxybenzene 1850
                                          guaiacols 1386
                                            vanillyl alcohol 8
                                              capsiate 7
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