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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:picrotoxin
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Accession:CHEBI:134126 term browser browse the term
Definition:A mixture consisting of equimolar amounts of picrotoxinin and picrotin found in the climbing plant Anamirta cocculus.
Synonyms:exact_synonym: (1R,3R,5S,8S,9R,12S,13R,14R)-1-hydroxy-13-methyl-14-(prop-1-en-2-yl)-4,7,10-trioxapentacyclo[6.4.1.1(9,12).0(3,5).0(5,13)]tetradecane-6,11-dione -- (1R,3R,5S,8S,9R,12S,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1(9,12).0(3,5).0(5,13)]tetradecane-6,11-dione (1:1)
 related_synonym: Cocculin;   Cocculus;   Coques du levant;   picrotoxine;   picrotoxinin - picrotin (1:1)
 xref: CAS:124-87-8;   HMDB:HMDB0014609
 xref_mesh: MESH:D010852
 xref: Reaxys:21526388;   Wikipedia:Picrotoxin


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picrotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 increases expression
decreases expression		 ISO Picrotoxin results in increased expression of ABCC8 mRNA; Picrotoxin results in increased expression of ABCC8 protein
Picrotoxin results in decreased expression of ABCC8 mRNA		 CTD PMID:18021373 NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894 		JBrowse link
G ACSL5 acyl-CoA synthetase long chain family member 5 decreases expression ISO Picrotoxin results in decreased expression of ACSL5 mRNA CTD PMID:15170462 NCBI chr10:112,374,116...112,428,376
Ensembl chr10:112,374,116...112,428,379 		JBrowse link
G ACSL6 acyl-CoA synthetase long chain family member 6 decreases expression ISO Picrotoxin results in decreased expression of ACSL6 mRNA CTD PMID:15170462 NCBI chr 5:131,949,973...132,012,213
Ensembl chr 5:131,949,973...132,012,243 		JBrowse link
G ADCY4 adenylate cyclase 4 increases expression ISO Picrotoxin results in increased expression of ADCY4 mRNA CTD PMID:15170462 NCBI chr14:24,318,359...24,335,071
Ensembl chr14:24,318,349...24,335,093 		JBrowse link
G ADRA1B adrenoceptor alpha 1B increases expression ISO Picrotoxin results in increased expression of ADRA1B mRNA CTD PMID:15170462 NCBI chr 5:159,865,086...159,989,205
Ensembl chr 5:159,865,080...159,973,012 		JBrowse link
G ADRA2A adrenoceptor alpha 2A increases expression ISO Picrotoxin results in increased expression of ADRA2A mRNA CTD PMID:15170462 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907 		JBrowse link
G ADRB2 adrenoceptor beta 2 increases expression ISO Picrotoxin results in increased expression of ADRB2 mRNA CTD PMID:15170462 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623 		JBrowse link
G AGTR1 angiotensin II receptor type 1 increases expression ISO Picrotoxin results in increased expression of AGTR1A mRNA CTD PMID:15170462 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTR2 angiotensin II receptor type 2 decreases expression ISO Picrotoxin results in decreased expression of AGTR2 mRNA CTD PMID:15170462 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G ALAD aminolevulinate dehydratase decreases activity
multiple interactions		 ISO Picrotoxin results in decreased activity of ALAD protein
carvacryl acetate inhibits the reaction [Picrotoxin results in decreased activity of ALAD protein]		 CTD PMID:25490531 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G ALDOB aldolase, fructose-bisphosphate B increases expression ISO Picrotoxin results in increased expression of ALDOB mRNA CTD PMID:15170462 NCBI chr 9:101,420,560...101,435,774
Ensembl chr 9:101,420,560...101,449,664 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type increases expression ISO Picrotoxin results in increased expression of ALOX12 mRNA CTD PMID:15170462 NCBI chr17:6,996,049...7,010,754
Ensembl chr17:6,996,049...7,010,754 		JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein increases expression ISO Picrotoxin results in increased expression of ALOX5AP mRNA CTD PMID:15170462 NCBI chr13:30,713,485...30,764,426
Ensembl chr13:30,713,478...30,764,426 		JBrowse link
G ATP5F1D ATP synthase F1 subunit delta decreases expression ISO Picrotoxin results in decreased expression of ATP5F1D mRNA CTD PMID:15170462 NCBI chr19:1,241,751...1,244,825
Ensembl chr19:1,241,746...1,244,825 		JBrowse link
G ATP5PO ATP synthase peripheral stalk subunit OSCP decreases expression ISO Picrotoxin results in decreased expression of ATP5PO mRNA CTD PMID:15170462 NCBI chr21:33,903,453...33,915,804
Ensembl chr21:33,903,453...33,915,814 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression ISO Picrotoxin results in decreased expression of BCL2L1 mRNA CTD PMID:15170462 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BDNF brain derived neurotrophic factor increases expression
decreases methylation		 ISO Picrotoxin results in increased expression of BDNF mRNA
Picrotoxin results in increased expression of BDNF protein
Picrotoxin results in decreased methylation of BDNF promoter		 CTD PMID:11279263 PMID:18184782 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CALB1 calbindin 1 decreases expression ISO Picrotoxin results in decreased expression of CALB1 protein CTD PMID:15382257 NCBI chr 8:90,058,608...90,082,879
Ensembl chr 8:90,058,608...90,095,475 		JBrowse link
G CALB2 calbindin 2 decreases expression ISO Picrotoxin results in decreased expression of CALB2 protein CTD PMID:15382257 NCBI chr16:71,358,723...71,390,433
Ensembl chr16:71,358,713...71,390,436 		JBrowse link
G CASP2 caspase 2 increases expression ISO Picrotoxin results in increased expression of CASP2 mRNA CTD PMID:15170462 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696 		JBrowse link
G CCKAR cholecystokinin A receptor increases expression ISO Picrotoxin results in increased expression of CCKAR mRNA CTD PMID:15170462 NCBI chr 4:26,481,396...26,490,484
Ensembl chr 4:26,481,396...26,490,484 		JBrowse link
G CCKBR cholecystokinin B receptor increases expression ISO Picrotoxin results in increased expression of CCKBR mRNA CTD PMID:15170462 NCBI chr11:6,259,838...6,272,127
Ensembl chr11:6,259,806...6,272,127 		JBrowse link
G CCND2 cyclin D2 decreases expression ISO Picrotoxin results in decreased expression of CCND2 mRNA CTD PMID:15170462 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353 		JBrowse link
G CCND3 cyclin D3 increases expression ISO Picrotoxin results in increased expression of CCND3 mRNA CTD PMID:15170462 NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 increases expression ISO Picrotoxin results in increased expression of CCR2 mRNA CTD PMID:15170462 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CHRM1 cholinergic receptor muscarinic 1 increases expression ISO Picrotoxin results in increased expression of CHRM1 mRNA CTD PMID:15170462 NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807 		JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 increases expression ISO Picrotoxin results in increased expression of CHRM2 mRNA CTD PMID:15170462 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255 		JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 increases expression ISO Picrotoxin results in increased expression of CHRM3 mRNA CTD PMID:15170462 NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression ISO Picrotoxin results in increased expression of CPT1A mRNA CTD PMID:15170462 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CPT1B carnitine palmitoyltransferase 1B increases expression ISO Picrotoxin results in increased expression of CPT1B mRNA CTD PMID:15170462 NCBI chr22:50,568,861...50,578,612
Ensembl chr22:50,568,861...50,578,465 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression ISO Picrotoxin results in increased expression of CXCR4 mRNA CTD PMID:15170462 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177 		JBrowse link
G DECR1 2,4-dienoyl-CoA reductase 1 decreases expression ISO Picrotoxin results in decreased expression of DECR1 mRNA CTD PMID:15170462 NCBI chr 8:90,001,477...90,053,633
Ensembl chr 8:90,001,405...90,053,633 		JBrowse link
G DHCR7 7-dehydrocholesterol reductase decreases expression ISO Picrotoxin results in decreased expression of DHCR7 mRNA CTD PMID:15170462 NCBI chr11:71,434,411...71,448,393
Ensembl chr11:71,428,193...71,452,868 		JBrowse link
G DRD4 dopamine receptor D4 increases expression ISO Picrotoxin results in increased expression of DRD4 mRNA CTD PMID:15170462 NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706 		JBrowse link
G EDN1 endothelin 1 multiple interactions ISO Picrotoxin inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EDN3 endothelin 3 multiple interactions ISO Picrotoxin inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 NCBI chr20:59,300,611...59,325,992
Ensembl chr20:59,300,443...59,325,992 		JBrowse link
G EDNRB endothelin receptor type B decreases expression ISO Picrotoxin results in decreased expression of EDNRB mRNA CTD PMID:15170462 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Picrotoxin results in increased expression of FOS; Picrotoxin results in increased expression of FOS mRNA CTD PMID:1380685 PMID:9500968 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Picrotoxin results in increased expression of FOSL1 mRNA CTD PMID:15170462 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573 		JBrowse link
G FSHR follicle stimulating hormone receptor increases expression ISO Picrotoxin results in increased expression of FSHR mRNA CTD PMID:15170462 NCBI chr 2:48,962,157...49,154,515
Ensembl chr 2:48,962,157...49,154,527 		JBrowse link
G FZD2 frizzled class receptor 2 increases expression ISO Picrotoxin results in increased expression of FZD2 mRNA CTD PMID:15170462 NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262 		JBrowse link
G GABBR2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions ISO 1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction [Picrotoxin affects the localization of GABBR2 protein]; Picrotoxin results in decreased expression of and affects the localization of GABBR2 protein CTD PMID:24482233 NCBI chr 9:98,288,109...98,708,935
Ensembl chr 9:98,288,109...98,708,935 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 multiple interactions EXP
ISO		 delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:9316872 PMID:14637376 PMID:17054655 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 multiple interactions EXP Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 PMID:14637376 NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230 		JBrowse link
G GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions EXP Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr 4:46,993,647...47,426,447
Ensembl chr 4:46,993,723...47,426,447 		JBrowse link
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 multiple interactions EXP
ISO		 Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:14637376 PMID:17054655 NCBI chr 5:161,288,436...161,548,404
Ensembl chr 5:161,288,429...161,549,044 		JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 multiple interactions EXP delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:9316872 NCBI chr15:26,543,552...26,773,763
Ensembl chr15:26,543,552...26,939,539 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 multiple interactions EXP
ISO		 delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:9316872 PMID:14637376 PMID:17054655 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977 		JBrowse link
G GAD1 glutamate decarboxylase 1 increases expression ISO Picrotoxin results in increased expression of GAD1 mRNA CTD PMID:15170462 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151 		JBrowse link
G GAD2 glutamate decarboxylase 2 increases response to substance
increases expression		 ISO GAD2 gene mutant form results in increased susceptibility to Picrotoxin
Picrotoxin results in increased expression of GAD2 mRNA; Picrotoxin results in increased expression of GAD2 protein		 CTD PMID:8954991 PMID:15170462 PMID:15382257 NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558 		JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP Picrotoxin binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr 5:151,822,513...151,924,851
Ensembl chr 5:151,822,513...151,924,851 		JBrowse link
G GNAI1 G protein subunit alpha i1 decreases expression ISO Picrotoxin results in decreased expression of GNAI1 mRNA CTD PMID:15170462 NCBI chr 7:80,134,831...80,226,181
Ensembl chr 7:79,768,028...80,226,181 		JBrowse link
G GNAI2 G protein subunit alpha i2 decreases expression ISO Picrotoxin results in decreased expression of GNAI2 mRNA CTD PMID:15170462 NCBI chr 3:50,227,068...50,263,358
Ensembl chr 3:50,226,292...50,259,362 		JBrowse link
G GNG8 G protein subunit gamma 8 increases expression ISO Picrotoxin results in increased expression of GNG8 mRNA CTD PMID:15170462 NCBI chr19:46,633,953...46,639,326
Ensembl chr19:46,633,953...46,636,541 		JBrowse link
G GNRHR gonadotropin releasing hormone receptor increases expression ISO Picrotoxin results in increased expression of GNRHR mRNA CTD PMID:15170462 NCBI chr 4:67,737,118...67,754,388
Ensembl chr 4:67,737,118...67,754,388 		JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 decreases expression ISO Picrotoxin results in decreased expression of GPD1 mRNA CTD PMID:15170462 NCBI chr12:50,104,008...50,111,313
Ensembl chr12:50,103,982...50,111,313 		JBrowse link
G HADHB hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression ISO Picrotoxin results in decreased expression of HADHB mRNA CTD PMID:15170462 NCBI chr 2:26,244,939...26,290,465
Ensembl chr 2:26,243,170...26,290,465 		JBrowse link
G HTR6 5-hydroxytryptamine receptor 6 increases expression ISO Picrotoxin results in increased expression of HTR6 mRNA CTD PMID:15170462 NCBI chr 1:19,664,875...19,680,966
Ensembl chr 1:19,664,875...19,680,966 		JBrowse link
G IDI1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Picrotoxin results in decreased expression of IDI1 mRNA CTD PMID:15170462 NCBI chr10:1,039,152...1,056,704
Ensembl chr10:1,039,152...1,049,119 		JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 decreases expression
increases expression		 ISO Picrotoxin results in decreased expression of KCNJ11 mRNA; Picrotoxin results in decreased expression of KCNJ11 protein
Picrotoxin results in increased expression of KCNJ11 mRNA; Picrotoxin results in increased expression of KCNJ11 protein		 CTD PMID:18021373 NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase decreases expression ISO Picrotoxin results in decreased expression of KRAS mRNA CTD PMID:15170462 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936 		JBrowse link
G LDHB lactate dehydrogenase B decreases expression ISO Picrotoxin results in decreased expression of LDHB mRNA CTD PMID:15170462 NCBI chr12:21,635,342...21,657,842
Ensembl chr12:21,635,342...21,757,857 		JBrowse link
G LDHC lactate dehydrogenase C increases expression ISO Picrotoxin results in increased expression of LDHC mRNA CTD PMID:15170462 NCBI chr11:18,412,318...18,452,063
Ensembl chr11:18,412,318...18,452,063 		JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor increases expression ISO Picrotoxin results in increased expression of LHCGR mRNA CTD PMID:15170462 NCBI chr 2:48,686,774...48,755,724
Ensembl chr 2:48,686,774...48,755,730 		JBrowse link
G LPL lipoprotein lipase decreases expression ISO Picrotoxin results in decreased expression of LPL mRNA CTD PMID:15170462 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G LTA4H leukotriene A4 hydrolase increases expression ISO Picrotoxin results in increased expression of LTA4H mRNA CTD PMID:15170462 NCBI chr12:96,000,753...96,043,520
Ensembl chr12:96,000,753...96,043,520 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein]
Picrotoxin results in increased phosphorylation of MAPK1 protein		 CTD PMID:35137321 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein]
Picrotoxin results in increased phosphorylation of MAPK3 protein		 CTD PMID:35137321 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MC4R melanocortin 4 receptor increases expression ISO Picrotoxin results in increased expression of MC4R mRNA CTD PMID:15170462 NCBI chr18:60,371,062...60,372,775
Ensembl chr18:60,371,062...60,372,775 		JBrowse link
G MVK mevalonate kinase increases expression ISO Picrotoxin results in increased expression of MVK mRNA CTD PMID:15170462 NCBI chr12:109,573,272...109,598,125
Ensembl chr12:109,573,255...109,598,125 		JBrowse link
G NDUFS6 NADH:ubiquinone oxidoreductase subunit S6 decreases expression ISO Picrotoxin results in decreased expression of NDUFS6 mRNA CTD PMID:15170462 NCBI chr 5:1,801,407...1,816,048
Ensembl chr 5:1,801,407...1,816,048 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 increases expression ISO Picrotoxin results in increased expression of NPY1R mRNA CTD PMID:15170462 NCBI chr 4:163,323,962...163,344,689
Ensembl chr 4:163,323,962...163,344,832 		JBrowse link
G OPRK1 opioid receptor kappa 1 increases expression ISO Picrotoxin results in increased expression of OPRK1 mRNA CTD PMID:15170462 NCBI chr 8:53,225,724...53,251,637
Ensembl chr 8:53,225,724...53,251,637 		JBrowse link
G OPRM1 opioid receptor mu 1 increases expression ISO Picrotoxin results in increased expression of OPRM1 mRNA CTD PMID:15170462 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
G PDE4D phosphodiesterase 4D increases expression ISO Picrotoxin results in increased expression of PDE4D mRNA CTD PMID:15170462 NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120 		JBrowse link
G PFKP phosphofructokinase, platelet decreases expression ISO Picrotoxin results in decreased expression of PFKP mRNA CTD PMID:15170462 NCBI chr10:3,067,548...3,136,805
Ensembl chr10:3,066,333...3,137,718 		JBrowse link
G PGAM1 phosphoglycerate mutase 1 decreases expression ISO Picrotoxin results in decreased expression of PGAM1 mRNA CTD PMID:15170462 NCBI chr10:97,426,191...97,433,444
Ensembl chr10:97,426,191...97,433,444 		JBrowse link
G PGAM2 phosphoglycerate mutase 2 increases expression ISO Picrotoxin results in increased expression of PGAM2 mRNA CTD PMID:15170462 NCBI chr 7:44,062,727...44,065,567
Ensembl chr 7:44,062,727...44,065,567 		JBrowse link
G PRKCD protein kinase C delta decreases expression ISO Picrotoxin results in decreased expression of PRKCD mRNA CTD PMID:15170462 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PRKCE protein kinase C epsilon decreases expression ISO Picrotoxin results in decreased expression of PRKCE mRNA CTD PMID:15170462 NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990 		JBrowse link
G PSMA3 proteasome 20S subunit alpha 3 decreases expression ISO Picrotoxin results in decreased expression of PSMA3 mRNA CTD PMID:15170462 NCBI chr14:58,244,843...58,272,004
Ensembl chr14:58,244,843...58,272,012 		JBrowse link
G PSMA4 proteasome 20S subunit alpha 4 decreases expression ISO Picrotoxin results in decreased expression of PSMA4 mRNA CTD PMID:15170462 NCBI chr15:78,540,405...78,552,417
Ensembl chr15:78,540,405...78,552,417 		JBrowse link
G PSMB8 proteasome 20S subunit beta 8 increases expression ISO Picrotoxin results in increased expression of PSMB8 mRNA CTD PMID:15170462 NCBI chr 6:32,840,717...32,844,679
Ensembl chr 6:32,840,717...32,844,679 		JBrowse link
G PSMC3 proteasome 26S subunit, ATPase 3 decreases expression ISO Picrotoxin results in decreased expression of PSMC3 mRNA CTD PMID:15170462 NCBI chr11:47,418,775...47,426,439
Ensembl chr11:47,418,769...47,426,473 		JBrowse link
G PVALB parvalbumin decreases expression ISO Picrotoxin results in decreased expression of PVALB protein CTD PMID:15382257 NCBI chr22:36,800,703...36,819,499
Ensembl chr22:36,800,684...36,819,479 		JBrowse link
G RYR2 ryanodine receptor 2 increases expression ISO Picrotoxin results in increased expression of RYR2 mRNA CTD PMID:21113126 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988 		JBrowse link
G SMAD1 SMAD family member 1 decreases expression ISO Picrotoxin results in decreased expression of SMAD1 mRNA CTD PMID:15170462 NCBI chr 4:145,480,770...145,559,176
Ensembl chr 4:145,481,194...145,559,176 		JBrowse link
G SMAD3 SMAD family member 3 increases expression ISO Picrotoxin results in increased expression of SMAD3 mRNA CTD PMID:15170462 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SMAD7 SMAD family member 7 decreases expression ISO Picrotoxin results in decreased expression of SMAD7 mRNA CTD PMID:15170462 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965 		JBrowse link
G SQLE squalene epoxidase decreases expression ISO Picrotoxin results in decreased expression of SQLE mRNA CTD PMID:15170462 NCBI chr 8:124,998,505...125,022,283
Ensembl chr 8:124,998,497...125,022,283 		JBrowse link
G SSTR2 somatostatin receptor 2 increases expression ISO Picrotoxin results in increased expression of SSTR2 mRNA CTD PMID:15170462 NCBI chr17:73,165,010...73,176,633
Ensembl chr17:73,165,010...73,176,633 		JBrowse link
G TGFBR3 transforming growth factor beta receptor 3 increases expression ISO Picrotoxin results in increased expression of TGFBR3 mRNA CTD PMID:15170462 NCBI chr 1:91,680,343...91,906,002
Ensembl chr 1:91,680,343...91,906,335 		JBrowse link
G TRHR thyrotropin releasing hormone receptor decreases expression ISO Picrotoxin results in decreased expression of TRHR mRNA CTD PMID:15170462 NCBI chr 8:109,086,585...109,121,565
Ensembl chr 8:109,086,585...109,121,565 		JBrowse link
G TSHR thyroid stimulating hormone receptor increases expression ISO Picrotoxin results in increased expression of TSHR mRNA CTD PMID:15170462 NCBI chr14:80,955,621...81,146,306
Ensembl chr14:80,954,989...81,146,306 		JBrowse link
G UCP2 uncoupling protein 2 increases expression ISO Picrotoxin results in increased expression of UCP2 mRNA CTD PMID:15170462 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843 		JBrowse link
G UCP3 uncoupling protein 3 increases expression ISO Picrotoxin results in increased expression of UCP3 mRNA CTD PMID:15170462 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    chemical entity 26020
      chemical substance 15508
        mixture 14678
          picrotoxin 96
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    main group molecular entity 25841
                      s-block molecular entity 25162
                        hydrogen molecular entity 24761
                          hydrides 22973
                            organic hydride 21936
                              organic fundamental parent 21936
                                hydrocarbon 21359
                                  terpene 14677
                                    terpenoid 14315
                                      sesquiterpenoid 3358
                                        picrotoxane sesquiterpenoid 100
                                          picrotoxinin 100
                                            picrotin 96
                                              picrotoxin 96
paths to the root