|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
[ABCB1A protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:30701287 |
|
NCBI chr 4:26,312,403...26,488,456
|
|
G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
multiple interactions |
ISO |
[ABCB1B protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:30701287 |
|
NCBI chr 4:26,197,706...26,280,156
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
[ABCC2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:30701287 |
|
NCBI chr 1:252,613,875...252,672,459
|
|
G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
[ABCC3 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:30701287 |
|
NCBI chr10:79,793,571...79,839,528
|
|
G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
affects transport multiple interactions |
ISO |
ABCG2 protein affects the transport of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine [ABCG2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:18322075 PMID:30701287 |
|
NCBI chr 4:89,006,056...89,132,915
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[CYP1A1 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine [[CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:16167840 PMID:17052995 PMID:17279779 |
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[[CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine metabolite [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:1943715 PMID:16167840 PMID:17279779 PMID:20192249 |
|
NCBI chr 8:66,971,261...66,978,149
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
[CYP1B1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:17279779 |
|
NCBI chr 6:21,093,927...21,103,091
|
|
G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions |
ISO |
[CYP2C19 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:17279779 |
|
NCBI chr 1:247,879,058...247,916,804
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions decreases activity |
ISO |
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [Estradiol results in increased activity of ESR1 protein] 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of ESR1 protein |
CTD |
PMID:16533016 |
|
NCBI chr 1:43,511,685...43,904,454
|
|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
increases expression |
EXP |
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA1 protein |
CTD |
PMID:17122891 |
|
NCBI chr 9:23,703,476...23,720,121
|
|
G |
Gsta3 |
glutathione S-transferase alpha 3 |
increases expression |
EXP |
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA3 protein |
CTD |
PMID:17122891 |
|
NCBI chr 9:23,658,574...23,684,240
|
|
G |
Gsta4 |
glutathione S-transferase alpha 4 |
increases expression |
EXP |
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA4 protein |
CTD |
PMID:17122891 |
|
NCBI chr 8:79,066,967...79,084,193
|
|
G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
EXP |
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTM1 protein |
CTD |
PMID:17122891 |
|
NCBI chr 2:198,338,005...198,346,007
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions decreases response to substance increases expression |
ISO EXP |
[GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] GSTP1 protein results in decreased susceptibility to 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTP1 protein |
CTD |
PMID:11196146 PMID:17122891 |
|
NCBI chr 1:210,767,237...210,770,242
|
|
G |
Nat1 |
N-acetyltransferase 1 |
multiple interactions increases metabolic processing |
ISO |
NAT1 protein affects the acetylation of and affects the activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine NAT1 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:11505221 PMID:29596660 |
|
NCBI chr16:22,218,217...22,238,516
|
|
G |
Nat2 |
N-acetyltransferase 2 |
multiple interactions increases acetylation increases metabolic processing |
EXP ISO |
4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] NAT2 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:12222688 PMID:18842621 PMID:29596660 |
|
NCBI chr16:26,974,874...27,005,191
|
|
G |
Pdia3 |
protein disulfide isomerase family A, member 3 |
affects expression multiple interactions |
EXP |
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of PDIA3 protein [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of PDIA3 protein |
CTD |
PMID:19639176 |
|
NCBI chr 3:128,841,781...128,865,733
|
|
G |
Rab7a |
RAB7A, member RAS oncogene family |
affects expression multiple interactions |
EXP |
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of RAB7A protein [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of RAB7A protein |
CTD |
PMID:19639176 |
|
NCBI chr 4:120,461,966...120,510,756
|
|
G |
Rps7 |
ribosomal protein S7 |
multiple interactions affects expression |
EXP |
[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of RPS7 protein 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of RPS7 protein |
CTD |
PMID:19639176 |
|
NCBI chr 6:50,994,581...50,999,447
|
|
G |
Sar1a |
secretion associated, Ras related GTPase 1A |
affects expression multiple interactions |
EXP |
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of SAR1A protein [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of SAR1A protein |
CTD |
PMID:19639176 |
|
NCBI chr20:30,166,310...30,178,718
|
|
G |
Sult1a1 |
sulfotransferase family 1A member 1 |
multiple interactions increases metabolic processing |
ISO |
SULT1A1 protein results in increased metabolism of and results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine SULT1A1 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:12067565 PMID:29596660 |
|
NCBI chr 1:190,702,592...190,706,112
|
|
G |
Tp53 |
tumor protein p53 |
increases mutagenesis |
ISO |
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of TP53 protein |
CTD |
PMID:33189884 |
|
NCBI chr10:54,798,871...54,810,300
|
|
G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
multiple interactions increases glucuronidation increases metabolic processing affects metabolic processing |
ISO |
UGT1A1 promoter polymorphism affects the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]; UGT1A1 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine UGT1A1 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine UGT1A1 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine UGT1A1 promoter polymorphism affects the metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:11442279 PMID:15310245 PMID:15769885 PMID:15986396 |
|
NCBI chr 9:96,249,143...96,256,264
|
|
G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:15310245 |
|
NCBI chr 9:96,239,019...96,256,264
|
|
G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases metabolic processing increases glucuronidation multiple interactions |
ISO |
UGT1A4 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine UGT1A4 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine UGT1A4 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides] |
CTD |
PMID:15310245 PMID:15986396 |
|
NCBI chr 9:96,210,053...96,256,264
|
|
G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
multiple interactions increases glucuronidation increases metabolic processing |
ISO |
UGT1A9 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides] UGT1A9 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine UGT1A9 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
CTD |
PMID:11375903 PMID:15310245 PMID:15986396 |
|
NCBI chr 9:96,144,786...96,256,264
|
|