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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thymol sulfate(1-)
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Accession:CHEBI:133663 term browser browse the term
Definition:A phenyl sulfate oxoanion that is the conjugate base of thymol sulfate, obtained by deprotonation of the sulfate group; major species at pH 7.3.
Synonyms:exact_synonym: 5-methyl-2-(propan-2-yl)phenyl sulfate
 related_synonym: Formula=C10H13O4S;   InChI=1S/C10H14O4S/c1-7(2)9-5-4-8(3)6-10(9)14-15(11,12)13/h4-7H,1-3H3,(H,11,12,13)/p-1;   InChIKey=NODSEPOUFZPJEQ-UHFFFAOYSA-M;   SMILES=C1(=C(C=C(C)C=C1)OS([O-])(=O)=O)C(C)C;   thymol sulfate
 xref: CAS:89-83-8;   KEGG:C09908
 xref_mesh: MESH:D013943
 cyclic_relationship: is_conjugate_base_of CHEBI:82911

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thymol sulfate(1-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:30048646 NCBI chr 9:22,126,727...22,135,746
Ensembl chr 9:22,126,727...22,135,711 		JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases activity		 ISO [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] results in increased activity of AHR protein; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] results in increased activity of AHR protein; Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
Thymol results in increased activity of AHR protein		 CTD PMID:29191726 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 affects localization ISO Thymol affects the localization of AIFM1 protein CTD PMID:21640085 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO Thymol results in increased expression of BAX protein CTD PMID:21640085 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO Thymol results in decreased expression of BCL2 protein CTD PMID:21640085 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO Thymol inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 mRNA] CTD PMID:26996544 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions EXP Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:30048646 NCBI chr 3:14,886,269...14,900,770
Ensembl chr 3:14,886,273...14,900,770 		JBrowse link
G Casp3 caspase 3 increases activity ISO Thymol results in increased activity of CASP3 protein CTD PMID:21640085 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 ISO Thymol results in increased activity of CASP8 protein
Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]		 CTD PMID:21640085 PMID:26996544 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA]
Thymol results in increased activity of CASP9 protein		 CTD PMID:21640085 PMID:26996544 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 Thymol inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]
Thymol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]		 CTD PMID:26680107 PMID:26721194 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Ctsk cathepsin K multiple interactions EXP Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein] CTD PMID:30048646 NCBI chr 3:95,499,210...95,509,387
Ensembl chr 3:95,499,256...95,509,362 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Thymol results in increased expression of CYP1A1 mRNA		 CTD PMID:29191726 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions EXP Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:30048646 NCBI chr15:39,745,930...39,760,938
Ensembl chr15:39,745,930...39,760,938 		JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions ISO Thymol inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA] CTD PMID:26996544 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions EXP Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol promotes the reaction [Lipopolysaccharides results in decreased expression of FOS protein] CTD PMID:30048646 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273 		JBrowse link
G Gab2 growth factor receptor bound protein 2-associated protein 2 multiple interactions EXP Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA] CTD PMID:30048646 NCBI chr 7:97,081,751...97,308,951
Ensembl chr 7:97,081,586...97,308,946 		JBrowse link
G Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 multiple interactions ISO Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr11:42,130,939...42,183,066
Ensembl chr11:42,130,939...42,182,930 		JBrowse link
G Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 multiple interactions ISO Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr11:42,419,515...42,632,591
Ensembl chr11:42,419,757...42,629,028 		JBrowse link
G Gabrg2 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 multiple interactions ISO Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr11:41,910,190...42,000,857
Ensembl chr11:41,910,203...42,000,857 		JBrowse link
G Gsr glutathione reductase multiple interactions EXP Thymol inhibits the reaction [Dietary Fats results in decreased activity of GSR protein] CTD PMID:26680107 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163 		JBrowse link
G Htr3a 5-hydroxytryptamine (serotonin) receptor 3A increases activity ISO Thymol results in increased activity of HTR3A protein CTD PMID:26456648 NCBI chr 9:48,899,213...48,911,152
Ensembl chr 9:48,899,213...48,911,099 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:30048646 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Mitf melanogenesis associated transcription factor multiple interactions EXP Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA] CTD PMID:30048646 NCBI chr 6:97,807,002...98,021,360
Ensembl chr 6:97,807,052...98,021,349 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein] CTD PMID:30048646 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions EXP Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA] CTD PMID:30048646 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374 		JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 multiple interactions EXP Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:30048646 NCBI chr18:80,606,205...80,713,071
Ensembl chr18:80,606,205...80,713,071 		JBrowse link
G Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) multiple interactions ISO Thymol inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein] CTD PMID:26721194 NCBI chr11:6,291,597...6,359,094
Ensembl chr11:6,291,633...6,356,642 		JBrowse link
G Src Rous sarcoma oncogene multiple interactions EXP Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA] CTD PMID:30048646 NCBI chr 2:157,423,906...157,471,838
Ensembl chr 2:157,418,444...157,471,862 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Thymol inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein] CTD PMID:26680107 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Thymol inhibits the reaction [Dietary Fats results in increased expression of TGFB1 protein] CTD PMID:26680107 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:30048646 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator multiple interactions EXP Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:30048646 NCBI chr 1:105,780,673...105,849,444
Ensembl chr 1:105,780,718...105,847,981 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions EXP Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:30048646 NCBI chr14:78,277,446...78,308,043
Ensembl chr14:78,277,445...78,308,043 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO
EXP		 Thymol results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr11:73,267,489...73,300,368
Ensembl chr11:73,267,388...73,300,363 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 1:88,055,411...88,220,002
Ensembl chr 1:88,055,388...88,219,004 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 1:88,070,779...88,220,002
Ensembl chr 1:88,070,800...88,218,997 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Thymol inhibits the reaction [Dietary Fats results in increased expression of VEGFA protein] CTD PMID:26680107 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21545
    role 21523
      biological role 21521
        biochemical role 20685
          volatile oil component 6107
            thymol 39
              thymol sulfate(1-) 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 21545
    subatomic particle 21530
      composite particle 21530
        hadron 21530
          baryon 21530
            nucleon 21530
              atomic nucleus 21530
                atom 21530
                  main group element atom 21434
                    p-block element atom 21434
                      chalcogen 20506
                        oxygen atom 20483
                          oxygen molecular entity 20483
                            oxide 12235
                              oxoanion 9126
                                chalcogen oxoanion 543
                                  sulfur oxoanion 542
                                    sulfate 498
                                      organosulfate oxoanion 498
                                        aryl sulfate oxoanion 39
                                          phenyl sulfate oxoanion 39
                                            thymol sulfate(1-) 39
paths to the root