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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:133474 term browser browse the term
Definition:A member of the class of naphthols that is naproxen in which the 6-methoxy group has been demethylated.
Synonyms:exact_synonym: (2S)-2-(6-hydroxynaphthalen-2-yl)propanoic acid
 related_synonym: (S)-2-(6-hydroxy-2-naphthyl)propionic acid;   (S)-2-(6-hydroxynaphthalen-2-yl)propanoic acid;   (S)-6-Hydroxy-alpha-methyl-2-naphthaleneacetic acid;   6-O-Demethylnaproxen;   Formula=C13H12O3;   InChI=1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1;   InChIKey=XWJUDDGELKXYNO-QMMMGPOBSA-N;   SMILES=C1=CC(=CC2=C1C=C(C=C2)[C@@H](C(=O)O)C)O
 xref: CAS:52079-10-4
 xref_mesh: MESH:C034451
 xref: PMID:1400763;   PMID:1400768;   PMID:1400803;   PMID:16187975;   PMID:16305588;   PMID:20006341;   PMID:2438972;   PMID:2566468;   PMID:3558575;   PMID:7086653;   PMID:712339;   PMID:8218967;   PMID:8512758;   Reaxys:8838512
 cyclic_relationship: is_conjugate_acid_of CHEBI:133481

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desmethylnaproxen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase multiple interactions ISO [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to desmethylnaproxen; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; desmethylnaproxen promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein] CTD PMID:28754375 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      chemical role 19356
        environmental contaminant 18751
          desmethylnaproxen 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic molecule 19587
                              organic cyclic compound 19393
                                carbocyclic compound 18510
                                  carbopolycyclic compound 17153
                                    carbobicyclic compound 5870
                                      naphthalenes 3822
                                        hydroxynaphthalene 255
                                          naphthols 246
                                            desmethylnaproxen 1
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