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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:desmethylnaproxen
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Accession:CHEBI:133474 term browser browse the term
Definition:A member of the class of naphthols that is naproxen in which the 6-methoxy group has been demethylated.
Synonyms:exact_synonym: (2S)-2-(6-hydroxynaphthalen-2-yl)propanoic acid
 related_synonym: (S)-2-(6-hydroxy-2-naphthyl)propionic acid;   (S)-2-(6-hydroxynaphthalen-2-yl)propanoic acid;   (S)-6-Hydroxy-alpha-methyl-2-naphthaleneacetic acid;   6-O-Demethylnaproxen;   Formula=C13H12O3;   InChI=1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1;   InChIKey=XWJUDDGELKXYNO-QMMMGPOBSA-N;   SMILES=C1=CC(=CC2=C1C=C(C=C2)[C@@H](C(=O)O)C)O
 xref: CAS:52079-10-4
 xref_mesh: MESH:C034451
 xref: PMID:1400763;   PMID:1400768;   PMID:1400803;   PMID:16187975;   PMID:16305588;   PMID:20006341;   PMID:2438972;   PMID:2566468;   PMID:3558575;   PMID:7086653;   PMID:712339;   PMID:8218967;   PMID:8512758;   Reaxys:8838512
 cyclic_relationship: is_conjugate_acid_of CHEBI:133481


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desmethylnaproxen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase multiple interactions ISO [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to desmethylnaproxen; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; desmethylnaproxen promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein] CTD PMID:28754375 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        environmental contaminant 18575
          desmethylnaproxen 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                carbocyclic compound 18183
                                  carbopolycyclic compound 16963
                                    carbobicyclic compound 4551
                                      naphthalenes 3737
                                        hydroxynaphthalene 235
                                          naphthols 228
                                            desmethylnaproxen 1
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