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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:[methyl(oxido)\{1-[6-(trifluoromethyl)pyridin-3-yl]ethyl\}-lambda(6)-sulfanylidene]cyanamide
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Accession:CHEBI:133306 term browser browse the term
Definition:A member of the class of pyridines that is 5-ethyl-2-trifluoromethylpyridine in which the ethyl group is substituted at position 1 by an N-cyano-S-methylsulfonimidoyl group. The insecticide sulfoxalor is a mixture of the four possible stereoisomers arising from the two tetrahedral stereocentres.
Synonyms:related_synonym: Formula=C10H10F3N3OS;   InChI=1S/C10H10F3N3OS/c1-7(18(2,17)16-6-14)8-3-4-9(15-5-8)10(11,12)13/h3-5,7H,1-2H3;   InChIKey=ZVQOOHYFBIDMTQ-UHFFFAOYSA-N;   SMILES=C=1(C=NC(=CC1)C(F)(F)F)C(S(C)(=NC#N)=O)C
 xref: PPDB:1669



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sulfoxaflor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
multiple interactions
EXP sulfoxaflor results in decreased activity of CAT protein
Resveratrol affects the reaction [sulfoxaflor results in decreased activity of CAT protein]
CTD PMID:33733559 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of CD3E mRNA
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of CD3E mRNA]
CTD PMID:33733559 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345
JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 9:87,862,417...87,870,833
Ensembl chr 9:87,862,407...87,870,833
JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 9:87,878,085...87,884,193
Ensembl chr 9:87,878,085...87,914,482
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions
EXP
ISO
sulfoxaflor results in increased expression of CYP2B1 mRNA
NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]
CTD PMID:23607986 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP sulfoxaflor results in increased expression of CYP3A23-3A1 mRNA CTD PMID:23607986 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
EXP Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of IFNG protein] CTD PMID:33733559 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of IL10 protein
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of IL10 protein]
CTD PMID:33733559 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of IL1B protein
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of IL1B protein]
CTD PMID:33733559 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of IL6 protein
Resveratrol affects the reaction [sulfoxaflor results in increased expression of IL6 protein]
CTD PMID:33733559 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of ITGAM mRNA
Resveratrol affects the reaction [sulfoxaflor results in increased expression of ITGAM mRNA]
CTD PMID:33733559 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases response to substance
ISO NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP3A11 mRNA]
NR1I2 protein results in increased susceptibility to sulfoxaflor
CTD PMID:23607986 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases response to substance
ISO NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP3A11 mRNA]
NR1I3 protein results in increased susceptibility to sulfoxaflor
CTD PMID:23607986 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of TNF protein
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of TNF protein]
CTD PMID:33733559 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    chemical entity 20068
      group 19989
        pseudohalo group 3914
          cyano group 3908
            nitrile 3908
              [methyl(oxido)\{1-[6-(trifluoromethyl)pyridin-3-yl]ethyl\}-lambda(6)-sulfanylidene]cyanamide 16
                (RC,RS)-sulfoxaflor + 16
                (RC,SS)-sulfoxaflor + 16
                (SC,RS)-sulfoxaflor + 16
                (SC,SS)-sulfoxaflor + 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19889
                        carbon atom 19894
                          organic molecular entity 19882
                            organic molecule 19830
                              organic cyclic compound 19603
                                organic heterocyclic compound 18888
                                  organic heteromonocyclic compound 17537
                                    pyridines 9194
                                      [methyl(oxido)\{1-[6-(trifluoromethyl)pyridin-3-yl]ethyl\}-lambda(6)-sulfanylidene]cyanamide 16
                                        (RC,RS)-sulfoxaflor + 16
                                        (RC,SS)-sulfoxaflor + 16
                                        (SC,RS)-sulfoxaflor + 16
                                        (SC,SS)-sulfoxaflor + 16
paths to the root