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ONTOLOGY REPORT - ANNOTATIONS


Term:microcystin RR
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Accession:CHEBI:133296 term browser browse the term
Definition:A microcystin consisting of D-alanyl, L-arginyl, (3S)-3-methyl-D-beta-aspartyl, L-arginyl, (2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle.
Synonyms:exact_synonym: (5R,8S,11R,12S,15S,18S,19S,22R)-8,15-bis(3-carbamimidamidopropyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,5,12,19-tetramethyl-2-methylidene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid;   cyclo[D-alanyl-L-arginyl-(3S)-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl-2,3-didehydro-N-methylalanyl]
 related_synonym: Cyanoginosin RR;   Formula=C49H75N13O12;   InChI=1S/C49H75N13O12/c1-26(24-27(2)37(74-8)25-32-14-10-9-11-15-32)18-19-33-28(3)40(64)60-36(46(70)71)20-21-38(63)62(7)31(6)43(67)56-30(5)42(66)59-35(17-13-23-55-49(52)53)45(69)61-39(47(72)73)29(4)41(65)58-34(44(68)57-33)16-12-22-54-48(50)51/h9-11,14-15,18-19,24,27-30,33-37,39H,6,12-13,16-17,20-23,25H2,1-5,7-8H3,(H,56,67)(H,57,68)(H,58,65)(H,59,66)(H,60,64)(H,61,69)(H,70,71)(H,72,73)(H4,50,51,54)(H4,52,53,55)/b19-18+,26-24+/t27-,28-,29-,30+,33-,34-,35-,36+,37-,39+/m0/s1;   InChIKey=JIGDOBKZMULDHS-UUHBQKJESA-N;   MC-RR;   SMILES=C([C@H](OC)[C@@H](C)\\C=C(/C)\\C=C\\[C@@]1(NC([C@H](CCCNC(=N)N)NC([C@H]([C@H](C(O)=O)NC([C@H](CCCNC(=N)N)NC([C@@H](C)NC(C(N(C(CC[C@@H](NC([C@H]1C)=O)C(O)=O)=O)C)=C)=O)=O)=O)C)=O)=O)[H])C=2C=CC=CC2
 xref: AGR:IND601212877 "Europe PMC";   CAS:111755-37-4 "ChemIDplus"
 xref_mesh: MESH:C063855
 xref: PMID:20196164 "Europe PMC";   PMID:20623858 "Europe PMC";   PMID:20704232 "Europe PMC";   PMID:21218261 "Europe PMC";   PMID:21829477 "Europe PMC";   PMID:22140076 "Europe PMC";   PMID:22177937 "Europe PMC";   PMID:22207040 "Europe PMC";   PMID:22250846 "Europe PMC";   PMID:22721844 "Europe PMC";   PMID:23272327 "Europe PMC";   PMID:23537600 "Europe PMC";   PMID:23538035 "Europe PMC";   PMID:23764611 "Europe PMC";   PMID:23785999 "Europe PMC";   PMID:23961204 "Europe PMC";   PMID:24152164 "Europe PMC";   PMID:24351711 "Europe PMC";   PMID:24868986 "Europe PMC";   PMID:24932741 "Europe PMC";   PMID:24950098 "Europe PMC";   PMID:25048936 "Europe PMC";   PMID:25193844 "Europe PMC";   PMID:25854999 "Europe PMC";   PMID:25892066 "Europe PMC";   PMID:25897773 "Europe PMC";   PMID:25978348 "Europe PMC";   PMID:26087964 "Europe PMC";   PMID:26896895 "Europe PMC";   PMID:26936473 "Europe PMC";   PMID:27453259 "Europe PMC";   Pubchem:6438357 "SUBMITTER"


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microcystin RR term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Ahsa1 activator of Hsp90 ATPase activity 1 JBrowse link 6 111,296,168 111,304,224 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Arpc5 actin related protein 2/3 complex, subunit 5 JBrowse link 13 70,174,970 70,183,879 RGD:6480464
G Atp5pd ATP synthase peripheral stalk subunit d JBrowse link 10 103,967,340 103,972,552 RGD:6480464
G Avp arginine vasopressin JBrowse link 3 123,117,482 123,119,460 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:6480464
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 JBrowse link 2 207,305,748 207,350,812 RGD:6480464
G Ccdc18 coiled-coil domain containing 18 JBrowse link 14
14
1,664,620
2,510,184
1,701,269
2,612,070
RGD:6480464
G Cct8 chaperonin containing TCP1 subunit 8 JBrowse link 11 27,130,172 27,141,881 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6480464
G Ciapin1 cytokine induced apoptosis inhibitor 1 JBrowse link 19 10,596,923 10,612,414 RGD:6480464
G Clic4 chloride intracellular channel 4 JBrowse link 5 153,568,937 153,625,669 RGD:6480464
G Cox5a cytochrome c oxidase subunit 5A JBrowse link 8 62,298,358 62,309,765 RGD:6480464
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6480464
G Csde1 cold shock domain containing E1 JBrowse link 2 205,525,194 205,552,987 RGD:6480464
G Echs1 enoyl-CoA hydratase, short chain 1 JBrowse link 1 212,570,213 212,579,040 RGD:6480464
G Eif2b3 eukaryotic translation initiation factor 2B subunit gamma JBrowse link 5 135,882,946 135,949,276 RGD:6480464
G Eif5a eukaryotic translation initiation factor 5A JBrowse link 10 56,527,075 56,531,615 RGD:6480464
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:6480464
G Erp29 endoplasmic reticulum protein 29 JBrowse link 12 40,619,377 40,625,884 RGD:6480464
G Esd esterase D JBrowse link 15 56,756,848 56,776,348 RGD:6480464
G Fabp5 fatty acid binding protein 5 JBrowse link 2 93,981,662 93,985,322 RGD:6480464
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:6480464
G G3bp1 G3BP stress granule assembly factor 1 JBrowse link 10 40,812,858 40,846,252 RGD:6480464
G Galnt13 polypeptide N-acetylgalactosaminyltransferase 13 JBrowse link 3 39,967,056 40,625,144 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:6480464
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:6480464
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Hypk Huntingtin interacting protein K JBrowse link 3 113,423,684 113,425,064 RGD:6480464
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha JBrowse link 8 59,164,601 59,183,899 RGD:6480464
G Immt inner membrane mitochondrial protein JBrowse link 4 99,753,446 99,789,921 RGD:6480464
G Impdh2 inosine monophosphate dehydrogenase 2 JBrowse link 8 117,346,983 117,351,619 RGD:6480464
G Kpna4 karyopherin subunit alpha 4 JBrowse link 2 165,684,345 165,739,874 RGD:6480464
G Krt10 keratin 10 JBrowse link 10 87,296,445 87,301,307 RGD:6480464
G Krt2 keratin 2 JBrowse link 7 143,412,858 143,420,463 RGD:6480464
G Ldhc lactate dehydrogenase C JBrowse link 1 102,914,875 102,931,843 RGD:6480464
G Lgals1 galectin 1 JBrowse link 7 120,153,184 120,156,290 RGD:6480464
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:6480464
G Macf1 microtubule-actin crosslinking factor 1 JBrowse link 5 141,039,455 141,363,524 RGD:6480464
G Mcm7 minichromosome maintenance complex component 7 JBrowse link 12 19,306,615 19,313,877 RGD:6480464
G Mrps22 mitochondrial ribosomal protein S22 JBrowse link 8 106,604,421 106,617,591 RGD:6480464
G Napg NSF attachment protein gamma JBrowse link 18 58,325,319 58,344,071 RGD:6480464
G Naxe NAD(P)HX epimerase JBrowse link 2 187,424,319 187,426,410 RGD:6480464
G Nit2 nitrilase family, member 2 JBrowse link 11 45,462,345 45,473,107 RGD:6480464
G Nutf2 nuclear transport factor 2 JBrowse link 19 37,830,917 37,852,192 RGD:6480464
G Pdcd6 programmed cell death 6 JBrowse link 1 31,576,183 31,591,852 RGD:6480464
G Pdia3 protein disulfide isomerase family A, member 3 JBrowse link 3 113,376,983 113,400,707 RGD:6480464
G Pgam1 phosphoglycerate mutase 1 JBrowse link 1 261,158,204 261,165,814 RGD:6480464
G Phpt1 phosphohistidine phosphatase 1 JBrowse link 3 2,797,037 2,798,436 RGD:6480464
G Pmpcb peptidase, mitochondrial processing beta subunit JBrowse link 4 9,908,838 9,921,615 RGD:6480464
G Pnp purine nucleoside phosphorylase JBrowse link 15 27,875,883 27,883,566 RGD:6480464
G Ppa1 inorganic pyrophosphatase 1 JBrowse link 20 31,265,519 31,292,451 RGD:6480464
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha JBrowse link 1 60,717,386 60,736,629 RGD:6480464
G Ppp2r5b protein phosphatase 2, regulatory subunit B', beta JBrowse link 1 221,597,294 221,605,467 RGD:6480464
G Prps2 phosphoribosyl pyrophosphate synthetase 2 JBrowse link X 28,435,275 28,472,882 RGD:6480464
G Psma1 proteasome 20S subunit alpha 1 JBrowse link 1 183,733,567 183,744,586 RGD:6480464
G Psmb2 proteasome 20S subunit beta 2 JBrowse link 5 144,702,004 144,734,220 RGD:6480464
G Psmb3 proteasome 20S subunit beta 3 JBrowse link 10 85,646,646 85,653,729 RGD:6480464
G Psmb4 proteasome 20S subunit beta 4 JBrowse link 2 196,043,546 196,046,320 RGD:6480464
G Psmb6 proteasome 20S subunit beta 6 JBrowse link 10 57,131,339 57,133,685 RGD:6480464
G Psmb9 proteasome 20S subunit beta 9 JBrowse link 20 3,973,424 3,978,845 RGD:6480464
G Psmd10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 112,323,188 112,328,642 RGD:6480464
G Psme1 proteasome activator subunit 1 JBrowse link 15 34,256,071 34,258,947 RGD:6480464
G Rab14 RAB14, member RAS oncogene family JBrowse link 3 14,373,270 14,395,357 RGD:6480464
G Rfc5 replication factor C subunit 5 JBrowse link 12 44,931,494 44,941,051 RGD:6480464
G Rtl8a retrotransposon Gag like 8A JBrowse link X 73,616,371 73,617,584 RGD:6480464
G Septin11 septin 11 JBrowse link 14 16,369,544 16,405,645 RGD:6480464
G Septin2 septin 2 JBrowse link 9 100,624,876 100,658,053 RGD:6480464
G Serpinb5 serpin family B member 5 JBrowse link 13 26,903,052 26,923,250 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Taldo1 transaldolase 1 JBrowse link 1 214,375,555 214,385,886 RGD:6480464
G Tbca tubulin folding cofactor A JBrowse link 2 24,449,498 24,505,351 RGD:6480464
G Tbcb tubulin folding cofactor B JBrowse link 1 88,680,936 88,686,785 RGD:6480464
G Timm50 translocase of inner mitochondrial membrane 50 JBrowse link 1 85,470,810 85,480,813 RGD:6480464
G Tnfrsf25 TNF receptor superfamily member 25 JBrowse link 5 169,288,419 169,293,137 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tpm4 tropomyosin 4 JBrowse link 16 19,385,810 19,399,851 RGD:6480464
G Trpc7 transient receptor potential cation channel, subfamily C, member 7 JBrowse link 17 8,134,267 8,280,360 RGD:6480464
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6480464
G Txnl1 thioredoxin-like 1 JBrowse link 18 59,056,454 59,086,278 RGD:6480464
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 11 86,304,836 86,328,478 RGD:6480464
G Vcl vinculin JBrowse link 15 3,455,211 3,544,738 RGD:6480464
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma JBrowse link 12 23,789,547 23,817,884 RGD:6480464
G Zfp951 zinc finger protein 951 JBrowse link 14 6,280,767 6,284,145 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        xenobiotic 18178
          microcystin RR 93
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                peptide 9297
                                                  cyclic peptide 8704
                                                    heterodetic cyclic peptide 1378
                                                      microcystin 468
                                                        microcystin RR 93
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.