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ONTOLOGY REPORT - ANNOTATIONS


Term:microcystin RR
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Accession:CHEBI:133296 term browser browse the term
Definition:A microcystin consisting of D-alanyl, L-arginyl, (3S)-3-methyl-D-beta-aspartyl, L-arginyl, (2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle.
Synonyms:exact_synonym: (5R,8S,11R,12S,15S,18S,19S,22R)-8,15-bis(3-carbamimidamidopropyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,5,12,19-tetramethyl-2-methylidene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid;   cyclo[D-alanyl-L-arginyl-(3S)-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl-2,3-didehydro-N-methylalanyl]
 related_synonym: Cyanoginosin RR;   Formula=C49H75N13O12;   InChI=1S/C49H75N13O12/c1-26(24-27(2)37(74-8)25-32-14-10-9-11-15-32)18-19-33-28(3)40(64)60-36(46(70)71)20-21-38(63)62(7)31(6)43(67)56-30(5)42(66)59-35(17-13-23-55-49(52)53)45(69)61-39(47(72)73)29(4)41(65)58-34(44(68)57-33)16-12-22-54-48(50)51/h9-11,14-15,18-19,24,27-30,33-37,39H,6,12-13,16-17,20-23,25H2,1-5,7-8H3,(H,56,67)(H,57,68)(H,58,65)(H,59,66)(H,60,64)(H,61,69)(H,70,71)(H,72,73)(H4,50,51,54)(H4,52,53,55)/b19-18+,26-24+/t27-,28-,29-,30+,33-,34-,35-,36+,37-,39+/m0/s1;   InChIKey=JIGDOBKZMULDHS-UUHBQKJESA-N;   MC-RR;   SMILES=C([C@H](OC)[C@@H](C)\\C=C(/C)\\C=C\\[C@@]1(NC([C@H](CCCNC(=N)N)NC([C@H]([C@H](C(O)=O)NC([C@H](CCCNC(=N)N)NC([C@@H](C)NC(C(N(C(CC[C@@H](NC([C@H]1C)=O)C(O)=O)=O)C)=C)=O)=O)=O)C)=O)=O)[H])C=2C=CC=CC2
 xref: AGR:IND601212877 "Europe PMC";   CAS:111755-37-4 "ChemIDplus"
 xref_mesh: MESH:C063855
 xref: PMID:20196164 "Europe PMC";   PMID:20623858 "Europe PMC";   PMID:20704232 "Europe PMC";   PMID:21218261 "Europe PMC";   PMID:21829477 "Europe PMC";   PMID:22140076 "Europe PMC";   PMID:22177937 "Europe PMC";   PMID:22207040 "Europe PMC";   PMID:22250846 "Europe PMC";   PMID:22721844 "Europe PMC";   PMID:23272327 "Europe PMC";   PMID:23537600 "Europe PMC";   PMID:23538035 "Europe PMC";   PMID:23764611 "Europe PMC";   PMID:23785999 "Europe PMC";   PMID:23961204 "Europe PMC";   PMID:24152164 "Europe PMC";   PMID:24351711 "Europe PMC";   PMID:24868986 "Europe PMC";   PMID:24932741 "Europe PMC";   PMID:24950098 "Europe PMC";   PMID:25048936 "Europe PMC";   PMID:25193844 "Europe PMC";   PMID:25854999 "Europe PMC";   PMID:25892066 "Europe PMC";   PMID:25897773 "Europe PMC";   PMID:25978348 "Europe PMC";   PMID:26087964 "Europe PMC";   PMID:26896895 "Europe PMC";   PMID:26936473 "Europe PMC";   PMID:27453259 "Europe PMC";   Pubchem:6438357 "SUBMITTER"


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microcystin RR term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 JBrowse link 11 105,967,948 105,989,964 RGD:6480464
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) JBrowse link 8 124,556,587 124,569,706 RGD:6480464
G Ahsa1 AHA1, activator of heat shock protein ATPase 1 JBrowse link 12 87,266,415 87,273,998 RGD:6480464
G Alb albumin JBrowse link 5 90,460,870 90,476,602 RGD:6480464
G Arpc5 actin related protein 2/3 complex, subunit 5 JBrowse link 1 152,766,542 152,775,580 RGD:6480464
G Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D JBrowse link 11 115,415,691 115,419,919 RGD:6480464
G Avp arginine vasopressin JBrowse link 2 130,580,620 130,582,588 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:6480464
G C1qbp complement component 1, q subcomponent binding protein JBrowse link 11 70,977,846 70,983,026 RGD:6480464
G Capza1 capping protein (actin filament) muscle Z-line, alpha 1 JBrowse link 3 104,822,781 104,864,505 RGD:6480464
G Ccdc18 coiled-coil domain containing 18 JBrowse link 5 108,132,661 108,240,512 RGD:6480464
G Cct8 chaperonin containing Tcp1, subunit 8 (theta) JBrowse link 16 87,483,325 87,495,869 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 10 127,063,535 127,067,288 RGD:6480464
G Cdkn2a cyclin dependent kinase inhibitor 2A JBrowse link 4 89,274,473 89,294,619 RGD:6480464
G Ciapin1 cytokine induced apoptosis inhibitor 1 JBrowse link 8 94,819,818 94,838,830 RGD:6480464
G Clic4 chloride intracellular channel 4 (mitochondrial) JBrowse link 4 135,213,969 135,272,760 RGD:6480464
G Cox5a cytochrome c oxidase subunit 5A JBrowse link 9 57,517,328 57,532,427 RGD:6480464
G Crkl v-crk avian sarcoma virus CT10 oncogene homolog-like JBrowse link 16 17,451,985 17,487,440 RGD:6480464
G Csde1 cold shock domain containing E1, RNA binding JBrowse link 3 103,020,431 103,058,186 RGD:6480464
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 JBrowse link 17 34,801,348 34,804,426 RGD:6480464
G Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial JBrowse link 7 140,105,710 140,116,421 RGD:6480464
G Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 JBrowse link 4 117,019,399 117,086,852 RGD:6480464
G Eif5a eukaryotic translation initiation factor 5A JBrowse link 11 69,916,712 69,921,958 RGD:6480464
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 JBrowse link 7 19,344,067 19,356,524 RGD:6480464
G Erp29 endoplasmic reticulum protein 29 JBrowse link 5 121,444,753 121,452,474 RGD:6480464
G Esd esterase D/formylglutathione hydrolase JBrowse link 14 74,732,151 74,750,765 RGD:6480464
G Fabp5 fatty acid binding protein 5, epidermal JBrowse link 3 10,012,585 10,016,610 RGD:6480464
G Flot1 flotillin 1 JBrowse link 17 35,823,320 35,832,789 RGD:6480464
G G3bp1 GTPase activating protein (SH3 domain) binding protein 1 JBrowse link 11 55,469,657 55,500,888 RGD:6480464
G Galnt13 polypeptide N-acetylgalactosaminyltransferase 13 JBrowse link 2 54,436,211 55,118,309 RGD:6480464
G Gpt glutamic pyruvic transaminase, soluble JBrowse link 15 76,696,726 76,699,675 RGD:6480464
G Gsta3 glutathione S-transferase, alpha 3 JBrowse link 1 21,240,565 21,265,575 RGD:6480464
G Gstm1 glutathione S-transferase, mu 1 JBrowse link 3 108,012,250 108,017,979 RGD:6480464
G Gstp1 glutathione S-transferase, pi 1 JBrowse link 19 4,035,411 4,037,912 RGD:6480464
G Gstt1 glutathione S-transferase, theta 1 JBrowse link 10 75,783,813 75,798,584 RGD:6480464
G Hspa1b heat shock protein 1B JBrowse link 17 34,956,429 34,959,238 RGD:6480464
G Hspa5 heat shock protein 5 JBrowse link 2 34,772,090 34,776,529 RGD:6480464
G Hypk huntingtin interacting protein K JBrowse link 2 121,457,088 121,458,440 RGD:6480464
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha JBrowse link 9 54,586,511 54,604,662 RGD:6480464
G Immt inner membrane protein, mitochondrial JBrowse link 6 71,831,091 71,875,266 RGD:6480464
G Impdh2 inosine monophosphate dehydrogenase 2 JBrowse link 9 108,560,291 108,565,584 RGD:6480464
G Kpna4 karyopherin (importin) alpha 4 JBrowse link 3 69,072,221 69,127,092 RGD:6480464
G Krt10 keratin 10 JBrowse link 11 99,385,254 99,397,449 RGD:6480464
G Krt2 keratin 2 JBrowse link 15 101,810,689 101,818,956 RGD:6480464
G Ldhc lactate dehydrogenase C JBrowse link 7 46,861,263 46,878,147 RGD:6480464
G Lgals1 lectin, galactose binding, soluble 1 JBrowse link 15 78,926,725 78,930,465 RGD:6480464
G Lmna lamin A JBrowse link 3 88,481,148 88,509,932 RGD:6480464
G Macf1 microtubule-actin crosslinking factor 1 JBrowse link 4 123,349,633 123,687,802 RGD:6480464
G Mcm7 minichromosome maintenance complex component 7 JBrowse link 5 138,164,583 138,172,111 RGD:6480464
G Mrps22 mitochondrial ribosomal protein S22 JBrowse link 9 98,588,730 98,601,679 RGD:6480464
G Napg N-ethylmaleimide sensitive fusion protein attachment protein gamma JBrowse link 18 62,977,836 62,999,450 RGD:6480464
G Naxe NAD(P)HX epimerase JBrowse link 3 88,056,520 88,058,542 RGD:6480464
G Nit2 nitrilase family, member 2 JBrowse link 16 57,156,665 57,167,332 RGD:6480464
G Nutf2 nuclear transport factor 2 JBrowse link 8 105,860,533 105,880,402 RGD:6480464
G Pdcd6 programmed cell death 6 JBrowse link 13 74,303,121 74,317,326 RGD:6480464
G Pdia3 protein disulfide isomerase associated 3 JBrowse link 2 121,413,902 121,438,687 RGD:6480464
G Pgam1 phosphoglycerate mutase 1 JBrowse link 19 41,911,871 41,918,665 RGD:6480464
G Phpt1 phosphohistidine phosphatase 1 JBrowse link 2 25,573,430 25,575,514 RGD:6480464
G Pmpcb peptidase (mitochondrial processing) beta JBrowse link 5 21,737,160 21,757,152 RGD:6480464
G Pnp2 purine-nucleoside phosphorylase 2 JBrowse link 14 50,956,141 50,964,751 RGD:6480464
G Ppa1 pyrophosphatase (inorganic) 1 JBrowse link 10 61,648,621 61,674,165 RGD:6480464
G Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha JBrowse link 17 20,945,454 20,965,905 RGD:6480464
G Ppp2r5b protein phosphatase 2, regulatory subunit B', beta JBrowse link 19 6,227,765 6,236,264 RGD:6480464
G Prps2 phosphoribosyl pyrophosphate synthetase 2 JBrowse link X 167,346,320 167,382,872 RGD:6480464
G Psma1 proteasome (prosome, macropain) subunit, alpha type 1 JBrowse link 7 114,264,550 114,276,116 RGD:6480464
G Psmb2 proteasome (prosome, macropain) subunit, beta type 2 JBrowse link 4 126,677,637 126,709,715 RGD:6480464
G Psmb3 proteasome (prosome, macropain) subunit, beta type 3 JBrowse link 11 97,703,434 97,713,500 RGD:6480464
G Psmb4 proteasome (prosome, macropain) subunit, beta type 4 JBrowse link 3 94,884,324 94,886,958 RGD:6480464
G Psmb6 proteasome (prosome, macropain) subunit, beta type 6 JBrowse link 11 70,525,324 70,527,858 RGD:6480464
G Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) JBrowse link 17 34,182,030 34,187,330 RGD:6480464
G Psmd10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 JBrowse link X 140,948,425 140,956,711 RGD:6480464
G Psme1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) JBrowse link 14 55,578,494 55,581,527 RGD:6480464
G Rab14 RAB14, member RAS oncogene family JBrowse link 2 35,180,205 35,201,120 RGD:6480464
G Rfc5 replication factor C (activator 1) 5 JBrowse link 5 117,379,145 117,389,023 RGD:6480464
G Sept11 septin 11 JBrowse link 5 93,090,995 93,182,368 RGD:6480464
G Sept2 septin 2 JBrowse link 1 93,478,969 93,509,733 RGD:6480464
G Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 JBrowse link 1 106,861,175 106,883,348 RGD:6480464
G Sod1 superoxide dismutase 1, soluble JBrowse link 16 90,220,762 90,226,333 RGD:6480464
G Taldo1 transaldolase 1 JBrowse link 7 141,392,160 141,402,976 RGD:6480464
G Tbca tubulin cofactor A JBrowse link 13 94,788,920 94,842,923 RGD:6480464
G Tbcb tubulin folding cofactor B JBrowse link 7 30,224,129 30,232,197 RGD:6480464
G Timm50 translocase of inner mitochondrial membrane 50 JBrowse link 7 28,305,516 28,312,046 RGD:6480464
G Tnfrsf25 tumor necrosis factor receptor superfamily, member 25 JBrowse link 4 152,115,528 152,120,119 RGD:6480464
G Tpm4 tropomyosin 4 JBrowse link 8 72,135,288 72,153,142 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464
G Trpc7 transient receptor potential cation channel, subfamily C, member 7 JBrowse link 13 56,773,098 56,895,968 RGD:6480464
G Txn1 thioredoxin 1 JBrowse link 4 57,943,373 57,956,411 RGD:6480464
G Txnl1 thioredoxin-like 1 JBrowse link 18 63,662,801 63,692,359 RGD:6480464
G Ufd1 ubiquitin recognition factor in ER-associated degradation 1 JBrowse link 16 18,811,736 18,835,261 RGD:6480464
G Vcl vinculin JBrowse link 14 20,929,383 21,033,676 RGD:6480464
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide JBrowse link 5 135,908,379 135,934,641 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20752
    role 20730
      biological role 20729
        xenobiotic 18727
          microcystin RR 92
Path 2
Term Annotations click to browse term
  CHEBI ontology 20752
    subatomic particle 20745
      composite particle 20745
        hadron 20745
          baryon 20745
            nucleon 20745
              atomic nucleus 20745
                atom 20745
                  main group element atom 20665
                    p-block element atom 20665
                      carbon group element atom 20401
                        carbon atom 20377
                          organic molecular entity 20377
                            organic group 19045
                              organic divalent group 19034
                                organodiyl group 19034
                                  carbonyl group 19007
                                    carbonyl compound 19007
                                      carboxylic acid 18675
                                        carboacyl group 17280
                                          univalent carboacyl group 17280
                                            carbamoyl group 16931
                                              carboxamide 16931
                                                peptide 9388
                                                  cyclic peptide 8814
                                                    heterodetic cyclic peptide 1416
                                                      microcystin 477
                                                        microcystin RR 92
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.