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ONTOLOGY REPORT - ANNOTATIONS


Term:microcystin RR
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Accession:CHEBI:133296 term browser browse the term
Definition:A microcystin consisting of D-alanyl, L-arginyl, (3S)-3-methyl-D-beta-aspartyl, L-arginyl, (2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle.
Synonyms:exact_synonym: (5R,8S,11R,12S,15S,18S,19S,22R)-8,15-bis(3-carbamimidamidopropyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,5,12,19-tetramethyl-2-methylidene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid;   cyclo[D-alanyl-L-arginyl-(3S)-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl-2,3-didehydro-N-methylalanyl]
 related_synonym: Cyanoginosin RR;   Formula=C49H75N13O12;   InChI=1S/C49H75N13O12/c1-26(24-27(2)37(74-8)25-32-14-10-9-11-15-32)18-19-33-28(3)40(64)60-36(46(70)71)20-21-38(63)62(7)31(6)43(67)56-30(5)42(66)59-35(17-13-23-55-49(52)53)45(69)61-39(47(72)73)29(4)41(65)58-34(44(68)57-33)16-12-22-54-48(50)51/h9-11,14-15,18-19,24,27-30,33-37,39H,6,12-13,16-17,20-23,25H2,1-5,7-8H3,(H,56,67)(H,57,68)(H,58,65)(H,59,66)(H,60,64)(H,61,69)(H,70,71)(H,72,73)(H4,50,51,54)(H4,52,53,55)/b19-18+,26-24+/t27-,28-,29-,30+,33-,34-,35-,36+,37-,39+/m0/s1;   InChIKey=JIGDOBKZMULDHS-UUHBQKJESA-N;   MC-RR;   SMILES=C([C@H](OC)[C@@H](C)\\C=C(/C)\\C=C\\[C@@]1(NC([C@H](CCCNC(=N)N)NC([C@H]([C@H](C(O)=O)NC([C@H](CCCNC(=N)N)NC([C@@H](C)NC(C(N(C(CC[C@@H](NC([C@H]1C)=O)C(O)=O)=O)C)=C)=O)=O)=O)C)=O)=O)[H])C=2C=CC=CC2
 xref: AGR:IND601212877 "Europe PMC";   CAS:111755-37-4 "ChemIDplus"
 xref_mesh: MESH:C063855
 xref: PMID:20196164 "Europe PMC";   PMID:20623858 "Europe PMC";   PMID:20704232 "Europe PMC";   PMID:21218261 "Europe PMC";   PMID:21829477 "Europe PMC";   PMID:22140076 "Europe PMC";   PMID:22177937 "Europe PMC";   PMID:22207040 "Europe PMC";   PMID:22250846 "Europe PMC";   PMID:22721844 "Europe PMC";   PMID:23272327 "Europe PMC";   PMID:23537600 "Europe PMC";   PMID:23538035 "Europe PMC";   PMID:23764611 "Europe PMC";   PMID:23785999 "Europe PMC";   PMID:23961204 "Europe PMC";   PMID:24152164 "Europe PMC";   PMID:24351711 "Europe PMC";   PMID:24868986 "Europe PMC";   PMID:24932741 "Europe PMC";   PMID:24950098 "Europe PMC";   PMID:25048936 "Europe PMC";   PMID:25193844 "Europe PMC";   PMID:25854999 "Europe PMC";   PMID:25892066 "Europe PMC";   PMID:25897773 "Europe PMC";   PMID:25978348 "Europe PMC";   PMID:26087964 "Europe PMC";   PMID:26896895 "Europe PMC";   PMID:26936473 "Europe PMC";   PMID:27453259 "Europe PMC";   Pubchem:6438357 "SUBMITTER"


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microcystin RR term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACE angiotensin I converting enzyme JBrowse link 17 63,477,061 63,498,373 RGD:6480464
G AGT angiotensinogen JBrowse link 1 230,702,523 230,714,122 RGD:6480464
G AHSA1 activator of HSP90 ATPase activity 1 JBrowse link 14 77,457,867 77,469,472 RGD:6480464
G ALB albumin JBrowse link 4 73,404,287 73,421,482 RGD:6480464
G ARPC5 actin related protein 2/3 complex subunit 5 JBrowse link 1 183,620,846 183,635,783 RGD:6480464
G ATP5PD ATP synthase peripheral stalk subunit d JBrowse link 17 75,038,863 75,046,969 RGD:6480464
G AVP arginine vasopressin JBrowse link 20 3,082,556 3,093,521 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6480464
G BCL2 BCL2 apoptosis regulator JBrowse link 18 63,123,346 63,320,280 RGD:6480464
G C1QBP complement C1q binding protein JBrowse link 17 5,432,777 5,439,155 RGD:6480464
G CAPZA1 capping actin protein of muscle Z-line subunit alpha 1 JBrowse link 1 112,619,775 112,671,616 RGD:6480464
G CCDC18 coiled-coil domain containing 18 JBrowse link 1 93,179,802 93,279,037 RGD:6480464
G CCT8 chaperonin containing TCP1 subunit 8 JBrowse link 21 29,056,322 29,073,797 RGD:6480464
G CDK4 cyclin dependent kinase 4 JBrowse link 12 57,747,727 57,752,310 RGD:6480464
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 21,967,752 21,995,324 RGD:6480464
G CIAPIN1 cytokine induced apoptosis inhibitor 1 JBrowse link 16 57,428,169 57,447,528 RGD:6480464
G CLIC4 chloride intracellular channel 4 JBrowse link 1 24,745,447 24,844,321 RGD:6480464
G COX5A cytochrome c oxidase subunit 5A JBrowse link 15 74,919,791 74,938,073 RGD:6480464
G CRKL CRK like proto-oncogene, adaptor protein JBrowse link 22 20,917,407 20,953,747 RGD:6480464
G CSDE1 cold shock domain containing E1 JBrowse link 1 114,716,913 114,758,050 RGD:6480464
G CYP21A2 cytochrome P450 family 21 subfamily A member 2 JBrowse link 6 32,038,306 32,041,670 RGD:6480464
G ECHS1 enoyl-CoA hydratase, short chain 1 JBrowse link 10 133,362,480 133,373,396 RGD:6480464
G EIF2B3 eukaryotic translation initiation factor 2B subunit gamma JBrowse link 1 44,850,522 44,986,722 RGD:6480464
G EIF5A eukaryotic translation initiation factor 5A JBrowse link 17 7,306,999 7,312,463 RGD:6480464
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 19 45,407,334 45,451,547 RGD:6480464
G ERP29 endoplasmic reticulum protein 29 JBrowse link 12 112,013,340 112,023,449 RGD:6480464
G ESD esterase D JBrowse link 13 46,771,256 46,797,700 RGD:6480464
G FABP5 fatty acid binding protein 5 JBrowse link 8 81,280,536 81,284,775 RGD:6480464
G FLOT1 flotillin 1 JBrowse link 6 30,727,709 30,742,851 RGD:6480464
G G3BP1 G3BP stress granule assembly factor 1 JBrowse link 5 151,771,954 151,812,785 RGD:6480464
G GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 JBrowse link 2 153,871,912 154,454,177 RGD:6480464
G GPT glutamic--pyruvic transaminase JBrowse link 8 144,502,217 144,507,174 RGD:6480464
G GSTA1 glutathione S-transferase alpha 1 JBrowse link 6 52,791,371 52,803,827 RGD:6480464
G GSTA3 glutathione S-transferase alpha 3 JBrowse link 6 52,896,646 52,909,799 RGD:6480464
G GSTM1 glutathione S-transferase mu 1 JBrowse link 1 109,687,817 109,693,745 RGD:6480464
G GSTP1 glutathione S-transferase pi 1 JBrowse link 11 67,583,812 67,586,653 RGD:6480464
G GSTT1 glutathione S-transferase theta 1 RGD:6480464
G HSPA1B heat shock protein family A (Hsp70) member 1B JBrowse link 6 31,827,738 31,830,254 RGD:6480464
G HSPA5 heat shock protein family A (Hsp70) member 5 JBrowse link 9 125,234,853 125,241,343 RGD:6480464
G HYPK huntingtin interacting protein K JBrowse link 15 43,800,421 43,804,427 RGD:6480464
G IDH3A isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha JBrowse link 15 78,149,362 78,171,945 RGD:6480464
G IMMT inner membrane mitochondrial protein JBrowse link 2 86,143,932 86,195,770 RGD:6480464
G IMPDH2 inosine monophosphate dehydrogenase 2 JBrowse link 3 49,024,325 49,029,750 RGD:6480464
G KPNA4 karyopherin subunit alpha 4 JBrowse link 3 160,495,007 160,565,571 RGD:6480464
G KRT10 keratin 10 JBrowse link 17 40,818,117 40,822,621 RGD:6480464
G KRT2 keratin 2 JBrowse link 12 52,644,558 52,652,211 RGD:6480464
G LDHC lactate dehydrogenase C JBrowse link 11 18,412,298 18,452,063 RGD:6480464
G LGALS1 galectin 1 JBrowse link 22 37,675,636 37,679,802 RGD:6480464
G LMNA lamin A/C JBrowse link 1 156,082,546 156,140,089 RGD:6480464
G MACF1 microtubule actin crosslinking factor 1 JBrowse link 1 39,084,167 39,487,138 RGD:6480464
G MCM7 minichromosome maintenance complex component 7 JBrowse link 7 100,092,728 100,101,397 RGD:6480464
G MRPS22 mitochondrial ribosomal protein S22 JBrowse link 3 139,343,994 139,357,140 RGD:6480464
G NAPG NSF attachment protein gamma JBrowse link 18 10,526,027 10,552,769 RGD:6480464
G NAXE NAD(P)HX epimerase JBrowse link 1 156,591,776 156,599,818 RGD:6480464
G NIT2 nitrilase family member 2 JBrowse link 3 100,334,757 100,361,635 RGD:6480464
G NUTF2 nuclear transport factor 2 JBrowse link 16 67,846,933 67,872,567 RGD:6480464
G PDCD6 programmed cell death 6 JBrowse link 5 271,621 314,974 RGD:6480464
G PDIA3 protein disulfide isomerase family A member 3 JBrowse link 15 43,746,438 43,773,278 RGD:6480464
G PGAM1 phosphoglycerate mutase 1 JBrowse link 10 97,426,191 97,433,444 RGD:6480464
G PHPT1 phosphohistidine phosphatase 1 JBrowse link 9 136,849,409 136,851,024 RGD:6480464
G PMPCB peptidase, mitochondrial processing beta subunit JBrowse link 7 103,297,435 103,329,902 RGD:6480464
G PNP purine nucleoside phosphorylase JBrowse link 14 20,469,379 20,478,006 RGD:6480464
G PPA1 inorganic pyrophosphatase 1 JBrowse link 10 70,202,831 70,233,429 RGD:6480464
G PPP2R1A protein phosphatase 2 scaffold subunit Aalpha JBrowse link 19 52,190,052 52,229,518 RGD:6480464
G PPP2R5B protein phosphatase 2 regulatory subunit B'beta JBrowse link 11 64,917,553 64,934,478 RGD:6480464
G PRPS2 phosphoribosyl pyrophosphate synthetase 2 JBrowse link X 12,791,355 12,824,227 RGD:6480464
G PSMA1 proteasome 20S subunit alpha 1 JBrowse link 11 14,504,876 14,643,634 RGD:6480464
G PSMB2 proteasome 20S subunit beta 2 JBrowse link 1 35,599,541 35,641,526 RGD:6480464
G PSMB3 proteasome 20S subunit beta 3 JBrowse link 17 38,752,741 38,764,225 RGD:6480464
G PSMB4 proteasome 20S subunit beta 4 JBrowse link 1 151,399,573 151,401,937 RGD:6480464
G PSMB6 proteasome 20S subunit beta 6 JBrowse link 17 4,796,144 4,798,503 RGD:6480464
G PSMB9 proteasome 20S subunit beta 9 JBrowse link 6 32,854,192 32,859,851 RGD:6480464
G PSMD10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 108,084,205 108,091,644 RGD:6480464
G PSME1 proteasome activator subunit 1 JBrowse link 14 24,136,158 24,138,967 RGD:6480464
G RAB14 RAB14, member RAS oncogene family JBrowse link 9 121,178,133 121,201,869 RGD:6480464
G RFC5 replication factor C subunit 5 JBrowse link 12 118,016,661 118,033,564 RGD:6480464
G RTL8A retrotransposon Gag like 8A JBrowse link X 135,050,932 135,052,191 RGD:6480464
G SEPTIN11 septin 11 JBrowse link 4 76,949,752 77,040,154 RGD:6480464
G SEPTIN2 septin 2 JBrowse link 2 241,315,187 241,354,027 RGD:6480464
G SERPINB5 serpin family B member 5 JBrowse link 18 63,476,958 63,505,085 RGD:6480464
G SOD1 superoxide dismutase 1 JBrowse link 21 31,659,622 31,668,931 RGD:6480464
G TALDO1 transaldolase 1 JBrowse link 11 747,464 765,012 RGD:6480464
G TBCA tubulin folding cofactor A JBrowse link 5 77,691,166 77,776,361 RGD:6480464
G TBCB tubulin folding cofactor B JBrowse link 19 36,114,986 36,125,948 RGD:6480464
G TIMM50 translocase of inner mitochondrial membrane 50 JBrowse link 19 39,480,838 39,493,779 RGD:6480464
G TNFRSF25 TNF receptor superfamily member 25 JBrowse link 1 6,461,151 6,466,195 RGD:6480464
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:6480464
G TPM4 tropomyosin 4 JBrowse link 19 16,067,507 16,103,005 RGD:6480464
G TRPC7 transient receptor potential cation channel subfamily C member 7 JBrowse link 5 136,213,311 136,365,476 RGD:6480464
G TXN thioredoxin JBrowse link 9 110,243,810 110,256,507 RGD:6480464
G TXNL1 thioredoxin like 1 JBrowse link 18 56,597,209 56,638,635 RGD:6480464
G UFD1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 22 19,449,911 19,479,193 RGD:6480464
G VCL vinculin JBrowse link 10 73,998,114 74,121,363 RGD:6480464
G YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma JBrowse link 7 76,326,799 76,358,991 RGD:6480464
G ZNF57 zinc finger protein 57 JBrowse link 19 2,900,928 2,918,646 RGD:6480464
G ZNF792 zinc finger protein 792 JBrowse link 19 34,956,354 34,964,229 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23680
    role 23568
      biological role 23529
        xenobiotic 19207
          microcystin RR 96
Path 2
Term Annotations click to browse term
  CHEBI ontology 23680
    subatomic particle 23627
      composite particle 23627
        hadron 23627
          baryon 23627
            nucleon 23627
              atomic nucleus 23627
                atom 23627
                  main group element atom 23444
                    p-block element atom 23444
                      carbon group element atom 23145
                        carbon atom 23121
                          organic molecular entity 23121
                            organic group 21820
                              organic divalent group 21790
                                organodiyl group 21790
                                  carbonyl group 21761
                                    carbonyl compound 21761
                                      carboxylic acid 20787
                                        carboacyl group 18729
                                          univalent carboacyl group 18729
                                            carbamoyl group 18049
                                              carboxamide 18049
                                                peptide 9753
                                                  cyclic peptide 9162
                                                    heterodetic cyclic peptide 1386
                                                      microcystin 482
                                                        microcystin RR 96
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.