|
G
|
Abca1
|
ATP binding cassette subfamily A member 1
|
increases expression
|
ISO
|
tetramethylpyrazine results in increased expression of ABCA1 protein
|
CTD |
PMID:28034800 |
|
NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473
|
|
G
|
Ache
|
acetylcholinesterase
|
multiple interactions
|
EXP
|
[huperzine A co-treated with tetramethylpyrazine] results in decreased activity of ACHE protein
|
CTD |
PMID:20624417 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
|
|
G
|
Acta2
|
actin alpha 2, smooth muscle
|
multiple interactions decreases expression
|
EXP ISO
|
tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of ACTA2 mRNA] NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 protein] tetramethylpyrazine results in decreased expression of ACTA2 mRNA; tetramethylpyrazine results in decreased expression of ACTA2 protein NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of ACTA2 protein]
|
CTD |
PMID:23022513 PMID:27477297 PMID:27837167 PMID:30744607 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of AKT1 mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased phosphorylation of AKT1 protein]
|
CTD |
PMID:30744607 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
G
|
Apoc3
|
apolipoprotein C3
|
decreases expression
|
ISO
|
tetramethylpyrazine results in decreased expression of APOC3 mRNA
|
CTD |
PMID:15520497 |
|
NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679
|
|
G
|
Asic3
|
acid sensing ion channel subunit 3
|
increases expression
|
ISO
|
tetramethylpyrazine results in increased expression of ASIC3 mRNA
|
CTD |
PMID:15520497 |
|
NCBI chr 4:11,652,946...11,657,415
Ensembl chr 4:11,652,946...11,657,367
|
|
G
|
Atp2a2
|
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
|
increases expression
|
ISO
|
tetramethylpyrazine results in increased expression of ATP2A2 mRNA
|
CTD |
PMID:15520497 |
|
NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
|
CTD |
PMID:26404762 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions
|
EXP
|
tetramethylpyrazine inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2 protein]
|
CTD |
PMID:21586279 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Bcl2l1
|
Bcl2-like 1
|
multiple interactions
|
EXP ISO
|
tetramethylpyrazine inhibits the reaction [Gentamicins results in decreased expression of BCL2L1 protein] tetramethylpyrazine inhibits the reaction [sodium arsenite results in decreased expression of BCL2L1 protein]
|
CTD |
PMID:17132701 PMID:26404762 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907 Ensembl chr 1:161,745,540...161,764,907
|
|
G
|
Becn1
|
beclin 1
|
multiple interactions
|
ISO
|
tetramethylpyrazine affects the reaction [Paraquat affects the expression of BECN1 protein]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of BECN1 mRNA]
|
CTD |
PMID:30744607 |
|
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
EXP ISO
|
tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP3 protein] [tetramethylpyrazine co-treated with evodiamine] results in increased activity of CASP3 protein; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]
|
CTD |
PMID:17132701 PMID:32135237 PMID:39486648 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp8
|
caspase 8
|
multiple interactions
|
EXP
|
tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP8 protein]; tetramethylpyrazine inhibits the reaction [TNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]]
|
CTD |
PMID:17132701 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
|
|
G
|
Casp9
|
caspase 9
|
multiple interactions
|
EXP ISO
|
tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP9 protein] tetramethylpyrazine inhibits the reaction [sodium arsenite results in decreased expression of CASP9 protein]
|
CTD |
PMID:17132701 PMID:26404762 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Cat
|
catalase
|
increases activity multiple interactions
|
ISO
|
tetramethylpyrazine results in increased activity of CAT protein DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]
|
CTD |
PMID:28034800 PMID:32135237 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Ccn2
|
cellular communication network factor 2
|
multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of CCN2 protein]
|
CTD |
PMID:30744607 |
|
NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
|
|
G
|
Cftr
|
CF transmembrane conductance regulator
|
multiple interactions increases activity
|
ISO EXP
|
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; RMI 12330A inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]
|
CTD |
PMID:15763242 PMID:16015685 |
|
NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643
|
|
G
|
Clu
|
clusterin
|
multiple interactions
|
EXP
|
tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in increased expression of CLU protein]
|
CTD |
PMID:24200859 |
|
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860
|
|
G
|
Col1a1
|
collagen type I alpha 1 chain
|
multiple interactions decreases expression
|
EXP ISO
|
tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of COL1A1 mRNA] tetramethylpyrazine results in decreased expression of COL1A1 mRNA; tetramethylpyrazine results in decreased expression of COL1A1 protein NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 protein] NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]
|
CTD |
PMID:23022513 PMID:27477297 PMID:27837167 |
|
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
|
|
G
|
Col3a1
|
collagen type III alpha 1 chain
|
multiple interactions
|
ISO
|
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]
|
CTD |
PMID:27477297 |
|
NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232
|
|
G
|
Ctnnb1
|
catenin beta 1
|
multiple interactions decreases expression
|
ISO
|
NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of CTNNB1 protein] tetramethylpyrazine results in decreased expression of CTNNB1 mRNA; tetramethylpyrazine results in decreased expression of CTNNB1 protein NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]
|
CTD |
PMID:24961358 PMID:27477297 |
|
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
|
|
G
|
Cyp11b2
|
cytochrome P450, family 11, subfamily b, polypeptide 2
|
increases expression
|
ISO
|
tetramethylpyrazine results in increased expression of CYP11B1 mRNA
|
CTD |
PMID:15520497 |
|
NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:108,719,349...108,725,763
|
|
G
|
Ddah2
|
DDAH family member 2, ADMA-independent
|
multiple interactions
|
ISO
|
DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased abundance of Nitric Oxide]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of Malondialdehyde]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of N,N-dimethylarginine]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of Reactive Oxygen Species]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]]; tetramethylpyrazine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased expression of DDAH2 protein]
|
CTD |
PMID:32135237 |
|
NCBI chr20:3,766,115...3,769,161
Ensembl chr20:3,766,120...3,769,183
|
|
G
|
Egfr
|
epidermal growth factor receptor
|
multiple interactions
|
ISO
|
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]
|
CTD |
PMID:27477297 |
|
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
|
|
G
|
Esr2
|
estrogen receptor 2
|
multiple interactions decreases expression
|
ISO
|
[evodiamine co-treated with tetramethylpyrazine] results in decreased expression of ESR2 mRNA; [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of ESR2 protein; [evodiamine co-treated with tetramethylpyrazine] results in increased methylation of ESR2 promoter; [tetramethylpyrazine co-treated with evodiamine] inhibits the reaction [POU5F1 protein binds to ESR2 promoter]; POU5F1 protein inhibits the reaction [tetramethylpyrazine results in decreased expression of ESR2 mRNA]; POU5F1 protein inhibits the reaction [tetramethylpyrazine results in decreased expression of ESR2 protein]; tetramethylpyrazine inhibits the reaction [POU5F1 protein binds to ESR2 promoter] tetramethylpyrazine results in decreased expression of ESR2 mRNA; tetramethylpyrazine results in decreased expression of ESR2 protein
|
CTD |
PMID:39486648 |
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709
|
|
G
|
Fn1
|
fibronectin 1
|
multiple interactions decreases expression
|
EXP ISO
|
tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of FN1 mRNA] NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 protein] tetramethylpyrazine results in decreased expression of FN1 mRNA; tetramethylpyrazine results in decreased expression of FN1 protein NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]
|
CTD |
PMID:23022513 PMID:27477297 PMID:27837167 |
|
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
EXP
|
[tetramethylpyrazine affects the expression of FOS mRNA] which results in decreased susceptibility to Methylnitrosourea
|
CTD |
PMID:16268501 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
|
|
G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
increases expression multiple interactions
|
ISO
|
tetramethylpyrazine analog results in increased expression of GCLC mRNA; tetramethylpyrazine analog results in increased expression of GCLC protein NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]
|
CTD |
PMID:25056784 PMID:27477297 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
|
|
G
|
Gclm
|
glutamate cysteine ligase, modifier subunit
|
multiple interactions
|
ISO
|
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]
|
CTD |
PMID:27477297 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
|
|
G
|
Gli1
|
GLI family zinc finger 1
|
multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of GLI1 mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of GLI1 protein]
|
CTD |
PMID:30744607 |
|
NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540
|
|
G
|
Gsr
|
glutathione-disulfide reductase
|
multiple interactions
|
EXP
|
tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]
|
CTD |
PMID:24200859 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
|
|
G
|
H2ax
|
H2A.X variant histone
|
multiple interactions
|
ISO
|
[tetramethylpyrazine co-treated with evodiamine] results in increased expression of H2AX protein
|
CTD |
PMID:39486648 |
|
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079
|
|
G
|
Havcr1
|
hepatitis A virus cellular receptor 1
|
multiple interactions
|
EXP
|
tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in increased expression of HAVCR1 protein]
|
CTD |
PMID:24200859 |
|
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268
|
|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions
|
ISO
|
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein]
|
CTD |
PMID:27837167 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
|
|
G
|
Hmox1
|
heme oxygenase 1
|
increases expression multiple interactions
|
ISO
|
tetramethylpyrazine analog results in increased expression of HMOX1 mRNA; tetramethylpyrazine analog results in increased expression of HMOX1 protein; tetramethylpyrazine results in increased expression of HMOX1 mRNA tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; tetramethylpyrazine results in increased expression of and results in increased activity of HMOX1 protein
|
CTD |
PMID:18842672 PMID:25056784 PMID:26404762 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
|
|
G
|
Ifng
|
interferon gamma
|
multiple interactions
|
ISO
|
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]
|
CTD |
PMID:27477297 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO
|
[evodiamine co-treated with tetramethylpyrazine] results in decreased expression of IL1B mRNA
|
CTD |
PMID:39486648 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of IL6 mRNA; [evodiamine co-treated with tetramethylpyrazine] results in decreased secretion of IL6 protein
|
CTD |
PMID:27477297 PMID:39486648 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
EXP ISO
|
[tetramethylpyrazine affects the expression of JUN mRNA] which results in decreased susceptibility to Methylnitrosourea tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of JUN protein modified form]
|
CTD |
PMID:16268501 PMID:26404762 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:26404762 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:26404762 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mapk8
|
mitogen-activated protein kinase 8
|
multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]
|
CTD |
PMID:26404762 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
|
|
G
|
Mapk9
|
mitogen-activated protein kinase 9
|
multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]
|
CTD |
PMID:26404762 |
|
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
|
|
G
|
Mir193a
|
microRNA 193a
|
multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of MIR193A mRNA]
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CTD |
PMID:30744607 |
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NCBI chr10:65,170,306...65,170,417
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|
G
|
Mki67
|
marker of proliferation Ki-67
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multiple interactions
|
ISO
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[evodiamine co-treated with tetramethylpyrazine] results in decreased expression of MKI67 protein
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CTD |
PMID:39486648 |
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NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
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G
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Mmp9
|
matrix metallopeptidase 9
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multiple interactions
|
ISO
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tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of MMP9 protein]
|
CTD |
PMID:30744607 |
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NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
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G
|
Mpo
|
myeloperoxidase
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multiple interactions
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ISO
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tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of MPO protein]
|
CTD |
PMID:22200888 |
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NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
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G
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Mtor
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mechanistic target of rapamycin kinase
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multiple interactions
|
ISO
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tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of MTOR mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased phosphorylation of MTOR protein]
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CTD |
PMID:30744607 |
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NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
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G
|
Nfe2l2
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NFE2 like bZIP transcription factor 2
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multiple interactions increases response to substance increases expression affects response to substance
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ISO
|
NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein] NFE2L2 protein results in increased susceptibility to tetramethylpyrazine tetramethylpyrazine analog results in increased expression of NFE2L2 protein; tetramethylpyrazine results in increased expression of NFE2L2 mRNA; tetramethylpyrazine results in increased expression of NFE2L2 protein NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein] NFE2L2 affects the susceptibility to tetramethylpyrazine
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CTD |
PMID:25056784 PMID:26404762 PMID:27477297 PMID:27837167 PMID:30744607 |
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NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
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G
|
Nfkbia
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NFKB inhibitor alpha
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multiple interactions
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EXP ISO
|
tetramethylpyrazine inhibits the reaction [Methylnitrosourea results in increased expression of NFKBIA protein] NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]
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CTD |
PMID:15960898 PMID:27477297 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
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G
|
Nlrp3
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NLR family, pyrin domain containing 3
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multiple interactions
|
ISO
|
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]
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CTD |
PMID:27477297 |
|
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
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G
|
Nos1
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nitric oxide synthase 1
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decreases expression
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EXP
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tetramethylpyrazine results in decreased expression of NOS1
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CTD |
PMID:17611313 |
|
NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837
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G
|
Nos2
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nitric oxide synthase 2
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increases expression multiple interactions
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EXP ISO
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tetramethylpyrazine results in increased expression of NOS2 mRNA tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of NOS2 mRNA]
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CTD |
PMID:15528953 PMID:22200888 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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G
|
Nos3
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nitric oxide synthase 3
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multiple interactions
|
ISO
|
DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]
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CTD |
PMID:32135237 |
|
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
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G
|
Nr1h3
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nuclear receptor subfamily 1, group H, member 3
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increases expression
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ISO
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tetramethylpyrazine results in increased expression of NR1H3 mRNA
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CTD |
PMID:28034800 |
|
NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532
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|
G
|
Parp1
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poly (ADP-ribose) polymerase 1
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multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
|
CTD |
PMID:26404762 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
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G
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Pdgfrb
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platelet derived growth factor receptor beta
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multiple interactions
|
EXP ISO
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tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB mRNA]; tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB protein] NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]
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CTD |
PMID:23022513 PMID:27477297 |
|
NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233
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G
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Pou5f1
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POU class 5 homeobox 1
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multiple interactions decreases expression
|
ISO
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[evodiamine co-treated with tetramethylpyrazine] results in decreased expression of POU5F1 protein; [tetramethylpyrazine co-treated with evodiamine] inhibits the reaction [POU5F1 protein binds to ESR2 promoter]; POU5F1 protein inhibits the reaction [tetramethylpyrazine results in decreased expression of ESR2 mRNA]; POU5F1 protein inhibits the reaction [tetramethylpyrazine results in decreased expression of ESR2 protein]; tetramethylpyrazine inhibits the reaction [POU5F1 protein binds to ESR2 promoter] tetramethylpyrazine results in decreased expression of POU5F1 protein
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CTD |
PMID:39486648 |
|
NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598
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G
|
Ppara
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peroxisome proliferator activated receptor alpha
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multiple interactions
|
ISO
|
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein]
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CTD |
PMID:27837167 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
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G
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Pparg
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peroxisome proliferator-activated receptor gamma
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increases expression multiple interactions
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EXP ISO
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tetramethylpyrazine results in increased expression of PPARG protein tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of PPARG protein] tetramethylpyrazine results in increased expression of PPARG mRNA
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CTD |
PMID:22200888 PMID:23022513 PMID:28034800 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
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G
|
Ptger3
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prostaglandin E receptor 3
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multiple interactions
|
ISO
|
[evodiamine co-treated with tetramethylpyrazine] results in decreased expression of PTGER3 mRNA
|
CTD |
PMID:39486648 |
|
NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:249,264,985...249,409,846
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G
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Ptgs2
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prostaglandin-endoperoxide synthase 2
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multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein] tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]
|
CTD |
PMID:22200888 PMID:24961358 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
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G
|
Rela
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RELA proto-oncogene, NF-kB subunit
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multiple interactions
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ISO EXP
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NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]; tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of RELA mRNA] tetramethylpyrazine promotes the reaction [Methylnitrosourea affects the localization of RELA protein] tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of RELA protein modified form]
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CTD |
PMID:15960898 PMID:22200888 PMID:24961358 PMID:27837167 |
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NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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G
|
Shh
|
sonic hedgehog signaling molecule
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multiple interactions
|
ISO
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tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SHH mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SHH protein]
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CTD |
PMID:30744607 |
|
NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901
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G
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Smad2
|
SMAD family member 2
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multiple interactions
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ISO
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tetramethylpyrazine inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein]
|
CTD |
PMID:30744607 |
|
NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388
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G
|
Smo
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smoothened, frizzled class receptor
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multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SMO mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SMO protein]
|
CTD |
PMID:30744607 |
|
NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281
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G
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Srebf1
|
sterol regulatory element binding transcription factor 1
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multiple interactions
|
ISO
|
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]
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CTD |
PMID:27837167 |
|
NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
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G
|
Srrt
|
serrate, RNA effector molecule
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multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of SRRT protein]
|
CTD |
PMID:26404762 |
|
NCBI chr12:25,027,883...25,042,847
Ensembl chr12:25,029,334...25,042,845
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G
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Tgfb1
|
transforming growth factor, beta 1
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multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of TGFB1 protein]
|
CTD |
PMID:30744607 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
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G
|
Tgfbr1
|
transforming growth factor, beta receptor 1
|
multiple interactions
|
ISO
|
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]
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CTD |
PMID:27477297 |
|
NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260
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G
|
Timp1
|
TIMP metallopeptidase inhibitor 1
|
multiple interactions
|
EXP
|
tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of TIMP1 protein]
|
CTD |
PMID:23022513 |
|
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135
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G
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Tnf
|
tumor necrosis factor
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multiple interactions
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ISO EXP
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[evodiamine co-treated with tetramethylpyrazine] results in decreased expression of TNF mRNA; [evodiamine co-treated with tetramethylpyrazine] results in decreased secretion of TNF protein; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of TNF protein] tetramethylpyrazine inhibits the reaction [TNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]] NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]; tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]
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CTD |
PMID:17132701 PMID:22200888 PMID:24961358 PMID:27477297 PMID:27837167 PMID:39486648 More...
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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G
|
Vegfa
|
vascular endothelial growth factor A
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multiple interactions
|
ISO
|
tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of VEGFA protein]
|
CTD |
PMID:30744607 |
|
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
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