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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetramethylpyrazine
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Accession:CHEBI:133246 term browser browse the term
Definition:A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).
Synonyms:related_synonym: 2,3,5,6,-tetramethyl-1,4-pyrazine;   2,3,5,6-tetramethylpyrazine;   FEMA 3237;   FEMA No. 3237;   Formula=C8H12N2;   InChI=1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3;   InChIKey=FINHMKGKINIASC-UHFFFAOYSA-N;   SMILES=C=1(N=C(C(=NC1C)C)C)C;   TMP;   liqustrazine
 xref: CAS:1124-11-4;   HMDB:HMDB0036584
 xref_mesh: MESH:C017953
 xref: MetaCyc:CPD-15901;   PMID:11583735;   PMID:18790005;   PMID:21456940;   PMID:23253813;   PMID:23563941;   PMID:2413290;   PMID:24333010;   PMID:25841319;   PMID:26275042;   PMID:26404762;   PMID:27179035;   PMID:27389185;   PMID:27391608;   PMID:27431939;   PMID:27607420;   PMID:27610159;   PMID:27717875;   Reaxys:113100;   Wikipedia:Tetramethylpyrazine


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tetramethylpyrazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO tetramethylpyrazine results in increased expression of ABCA1 protein CTD PMID:28034800 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [huperzine A co-treated with tetramethylpyrazine] results in decreased activity of ACHE protein CTD PMID:20624417 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression 		EXP
ISO 		tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of ACTA2 mRNA]
NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 protein]
tetramethylpyrazine results in decreased expression of ACTA2 mRNA; tetramethylpyrazine results in decreased expression of ACTA2 protein
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of ACTA2 protein] 		CTD PMID:23022513 PMID:27477297 PMID:27837167 PMID:30744607 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of AKT1 mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased phosphorylation of AKT1 protein] CTD PMID:30744607 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression ISO tetramethylpyrazine results in decreased expression of APOC3 mRNA CTD PMID:15520497 NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679 		JBrowse link
G Asic3 acid sensing ion channel subunit 3 increases expression ISO tetramethylpyrazine results in increased expression of ASIC3 mRNA CTD PMID:15520497 NCBI chr 4:11,652,946...11,657,415
Ensembl chr 4:11,652,946...11,657,367 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression ISO tetramethylpyrazine results in increased expression of ATP2A2 mRNA CTD PMID:15520497 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of BAX protein] CTD PMID:26404762 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP tetramethylpyrazine inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2 protein] CTD PMID:21586279 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP
ISO 		tetramethylpyrazine inhibits the reaction [Gentamicins results in decreased expression of BCL2L1 protein]
tetramethylpyrazine inhibits the reaction [sodium arsenite results in decreased expression of BCL2L1 protein] 		CTD PMID:17132701 PMID:26404762 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO tetramethylpyrazine affects the reaction [Paraquat affects the expression of BECN1 protein]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of BECN1 mRNA] CTD PMID:30744607 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO 		tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP3 protein]
[tetramethylpyrazine co-treated with evodiamine] results in increased activity of CASP3 protein; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form] 		CTD PMID:17132701 PMID:32135237 PMID:39486648 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP8 protein]; tetramethylpyrazine inhibits the reaction [TNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]] CTD PMID:17132701 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO 		tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP9 protein]
tetramethylpyrazine inhibits the reaction [sodium arsenite results in decreased expression of CASP9 protein] 		CTD PMID:17132701 PMID:26404762 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase increases activity
multiple interactions 		ISO tetramethylpyrazine results in increased activity of CAT protein
DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein] 		CTD PMID:28034800 PMID:32135237 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of CCN2 protein] CTD PMID:30744607 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity 		ISO
EXP 		1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; RMI 12330A inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein] CTD PMID:15763242 PMID:16015685 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643 		JBrowse link
G Clu clusterin multiple interactions EXP tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in increased expression of CLU protein] CTD PMID:24200859 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression 		EXP
ISO 		tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of COL1A1 mRNA]
tetramethylpyrazine results in decreased expression of COL1A1 mRNA; tetramethylpyrazine results in decreased expression of COL1A1 protein
NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 protein]
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein] 		CTD PMID:23022513 PMID:27477297 PMID:27837167 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein] CTD PMID:27477297 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression 		ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of CTNNB1 protein]
tetramethylpyrazine results in decreased expression of CTNNB1 mRNA; tetramethylpyrazine results in decreased expression of CTNNB1 protein
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein] 		CTD PMID:24961358 PMID:27477297 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases expression ISO tetramethylpyrazine results in increased expression of CYP11B1 mRNA CTD PMID:15520497 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:108,719,349...108,725,763 		JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent multiple interactions ISO DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased abundance of Nitric Oxide]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of Malondialdehyde]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of N,N-dimethylarginine]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of Reactive Oxygen Species]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]]; tetramethylpyrazine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased expression of DDAH2 protein] CTD PMID:32135237 NCBI chr20:3,766,115...3,769,161
Ensembl chr20:3,766,120...3,769,183 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein] CTD PMID:27477297 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression 		ISO [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of ESR2 mRNA; [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of ESR2 protein; [evodiamine co-treated with tetramethylpyrazine] results in increased methylation of ESR2 promoter; [tetramethylpyrazine co-treated with evodiamine] inhibits the reaction [POU5F1 protein binds to ESR2 promoter]; POU5F1 protein inhibits the reaction [tetramethylpyrazine results in decreased expression of ESR2 mRNA]; POU5F1 protein inhibits the reaction [tetramethylpyrazine results in decreased expression of ESR2 protein]; tetramethylpyrazine inhibits the reaction [POU5F1 protein binds to ESR2 promoter]
tetramethylpyrazine results in decreased expression of ESR2 mRNA; tetramethylpyrazine results in decreased expression of ESR2 protein 		CTD PMID:39486648 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression 		EXP
ISO 		tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of FN1 mRNA]
NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 protein]
tetramethylpyrazine results in decreased expression of FN1 mRNA; tetramethylpyrazine results in decreased expression of FN1 protein
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein] 		CTD PMID:23022513 PMID:27477297 PMID:27837167 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [tetramethylpyrazine affects the expression of FOS mRNA] which results in decreased susceptibility to Methylnitrosourea CTD PMID:16268501 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions 		ISO tetramethylpyrazine analog results in increased expression of GCLC mRNA; tetramethylpyrazine analog results in increased expression of GCLC protein
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein] 		CTD PMID:25056784 PMID:27477297 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein] CTD PMID:27477297 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of GLI1 mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of GLI1 protein] CTD PMID:30744607 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein] CTD PMID:24200859 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [tetramethylpyrazine co-treated with evodiamine] results in increased expression of H2AX protein CTD PMID:39486648 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in increased expression of HAVCR1 protein] CTD PMID:24200859 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein] CTD PMID:27837167 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions 		ISO tetramethylpyrazine analog results in increased expression of HMOX1 mRNA; tetramethylpyrazine analog results in increased expression of HMOX1 protein; tetramethylpyrazine results in increased expression of HMOX1 mRNA
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; tetramethylpyrazine results in increased expression of and results in increased activity of HMOX1 protein 		CTD PMID:18842672 PMID:25056784 PMID:26404762 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Ifng interferon gamma multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein] CTD PMID:27477297 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of IL1B mRNA CTD PMID:39486648 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]
[evodiamine co-treated with tetramethylpyrazine] results in decreased expression of IL6 mRNA; [evodiamine co-treated with tetramethylpyrazine] results in decreased secretion of IL6 protein 		CTD PMID:27477297 PMID:39486648 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO 		[tetramethylpyrazine affects the expression of JUN mRNA] which results in decreased susceptibility to Methylnitrosourea
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of JUN protein modified form] 		CTD PMID:16268501 PMID:26404762 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein] CTD PMID:26404762 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:26404762 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein] CTD PMID:26404762 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein] CTD PMID:26404762 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mir193a microRNA 193a multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of MIR193A mRNA] CTD PMID:30744607 NCBI chr10:65,170,306...65,170,417 JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of MKI67 protein CTD PMID:39486648 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of MMP9 protein] CTD PMID:30744607 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of MPO protein] CTD PMID:22200888 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of MTOR mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased phosphorylation of MTOR protein] CTD PMID:30744607 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases response to substance
increases expression
affects response to substance 		ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]
NFE2L2 protein results in increased susceptibility to tetramethylpyrazine
tetramethylpyrazine analog results in increased expression of NFE2L2 protein; tetramethylpyrazine results in increased expression of NFE2L2 mRNA; tetramethylpyrazine results in increased expression of NFE2L2 protein
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]
NFE2L2 affects the susceptibility to tetramethylpyrazine 		CTD PMID:25056784 PMID:26404762 PMID:27477297 PMID:27837167 PMID:30744607 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO 		tetramethylpyrazine inhibits the reaction [Methylnitrosourea results in increased expression of NFKBIA protein]
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein] 		CTD PMID:15960898 PMID:27477297 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein] CTD PMID:27477297 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression EXP tetramethylpyrazine results in decreased expression of NOS1 CTD PMID:17611313 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions 		EXP
ISO 		tetramethylpyrazine results in increased expression of NOS2 mRNA
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of NOS2 mRNA] 		CTD PMID:15528953 PMID:22200888 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein] CTD PMID:32135237 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO tetramethylpyrazine results in increased expression of NR1H3 mRNA CTD PMID:28034800 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:26404762 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP
ISO 		tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB mRNA]; tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB protein]
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein] 		CTD PMID:23022513 PMID:27477297 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions
decreases expression 		ISO [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of POU5F1 protein; [tetramethylpyrazine co-treated with evodiamine] inhibits the reaction [POU5F1 protein binds to ESR2 promoter]; POU5F1 protein inhibits the reaction [tetramethylpyrazine results in decreased expression of ESR2 mRNA]; POU5F1 protein inhibits the reaction [tetramethylpyrazine results in decreased expression of ESR2 protein]; tetramethylpyrazine inhibits the reaction [POU5F1 protein binds to ESR2 promoter]
tetramethylpyrazine results in decreased expression of POU5F1 protein 		CTD PMID:39486648 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein] CTD PMID:27837167 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions 		EXP
ISO 		tetramethylpyrazine results in increased expression of PPARG protein
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of PPARG protein]
tetramethylpyrazine results in increased expression of PPARG mRNA 		CTD PMID:22200888 PMID:23022513 PMID:28034800 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions ISO [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of PTGER3 mRNA CTD PMID:39486648 NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:249,264,985...249,409,846 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA] 		CTD PMID:22200888 PMID:24961358 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP 		NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]; tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of RELA mRNA]
tetramethylpyrazine promotes the reaction [Methylnitrosourea affects the localization of RELA protein]
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of RELA protein modified form] 		CTD PMID:15960898 PMID:22200888 PMID:24961358 PMID:27837167 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SHH mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SHH protein] CTD PMID:30744607 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein] CTD PMID:30744607 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SMO mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SMO protein] CTD PMID:30744607 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein] CTD PMID:27837167 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Srrt serrate, RNA effector molecule multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of SRRT protein] CTD PMID:26404762 NCBI chr12:25,027,883...25,042,847
Ensembl chr12:25,029,334...25,042,845 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of TGFB1 protein] CTD PMID:30744607 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein] CTD PMID:27477297 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of TIMP1 protein] CTD PMID:23022513 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		[evodiamine co-treated with tetramethylpyrazine] results in decreased expression of TNF mRNA; [evodiamine co-treated with tetramethylpyrazine] results in decreased secretion of TNF protein; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
tetramethylpyrazine inhibits the reaction [TNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]]
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]; tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of TNF mRNA] 		CTD PMID:17132701 PMID:22200888 PMID:24961358 PMID:27477297 PMID:27837167 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of VEGFA protein] CTD PMID:30744607 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    role 20801
      biological role 20799
        inhibitor 19464
          apoptosis inhibitor 9821
            tetramethylpyrazine 73
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      carbon group element atom 20695
                        carbon atom 20690
                          organic molecular entity 20690
                            organic molecule 20634
                              organic cyclic compound 20385
                                organic heterocyclic compound 19373
                                  organic heteromonocyclic compound 18194
                                    diazines 13840
                                      pyrazines 1098
                                        tetramethylpyrazine 73
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