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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetramethylpyrazine
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Accession:CHEBI:133246 term browser browse the term
Definition:A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).
Synonyms:related_synonym: 2,3,5,6,-tetramethyl-1,4-pyrazine;   2,3,5,6-tetramethylpyrazine;   FEMA 3237;   FEMA No. 3237;   Formula=C8H12N2;   InChI=1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3;   InChIKey=FINHMKGKINIASC-UHFFFAOYSA-N;   SMILES=C=1(N=C(C(=NC1C)C)C)C;   TMP;   liqustrazine
 xref: CAS:1124-11-4;   HMDB:HMDB0036584
 xref_mesh: MESH:C017953
 xref: MetaCyc:CPD-15901;   PMID:11583735;   PMID:18790005;   PMID:21456940;   PMID:23253813;   PMID:23563941;   PMID:2413290;   PMID:24333010;   PMID:25841319;   PMID:26275042;   PMID:26404762;   PMID:27179035;   PMID:27389185;   PMID:27391608;   PMID:27431939;   PMID:27607420;   PMID:27610159;   PMID:27717875;   Reaxys:113100;   Wikipedia:Tetramethylpyrazine


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tetramethylpyrazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO tetramethylpyrazine results in increased expression of ABCA1 protein CTD PMID:28034800 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [huperzine A co-treated with tetramethylpyrazine] results in decreased activity of ACHE protein CTD PMID:20624417 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
EXP
ISO
tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of ACTA2 mRNA]
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]
tetramethylpyrazine results in decreased expression of ACTA2 mRNA; tetramethylpyrazine results in decreased expression of ACTA2 protein
NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 protein]
CTD PMID:23022513, PMID:27477297, PMID:27837167 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression ISO tetramethylpyrazine results in decreased expression of APOC3 mRNA CTD PMID:15520497 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Asic3 acid sensing ion channel subunit 3 increases expression ISO tetramethylpyrazine results in increased expression of ASIC3 mRNA CTD PMID:15520497 NCBI chr 4:7,287,868...7,293,295
Ensembl chr 4:7,288,855...7,292,901
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression ISO tetramethylpyrazine results in increased expression of ATP2A2 mRNA CTD PMID:15520497 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of BAX protein] CTD PMID:26404762 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP tetramethylpyrazine inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2 protein] CTD PMID:21586279 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP
ISO
tetramethylpyrazine inhibits the reaction [Gentamicins results in decreased expression of BCL2L1 protein]
tetramethylpyrazine inhibits the reaction [sodium arsenite results in decreased expression of BCL2L1 protein]
CTD PMID:17132701, PMID:26404762 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions EXP tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP3 protein] CTD PMID:17132701 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions EXP tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP8 protein]; tetramethylpyrazine inhibits the reaction [TNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]] CTD PMID:17132701 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO
tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP9 protein]
tetramethylpyrazine inhibits the reaction [sodium arsenite results in decreased expression of CASP9 protein]
CTD PMID:17132701, PMID:26404762 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity ISO tetramethylpyrazine results in increased activity of CAT protein CTD PMID:28034800 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; RMI 12330A inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein] CTD PMID:15763242, PMID:16015685 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Clu clusterin multiple interactions EXP tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in increased expression of CLU protein] CTD PMID:24200859 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
EXP
ISO
tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of COL1A1 mRNA]
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]
NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 protein]
tetramethylpyrazine results in decreased expression of COL1A1 mRNA; tetramethylpyrazine results in decreased expression of COL1A1 protein
CTD PMID:23022513, PMID:27477297, PMID:27837167 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein] CTD PMID:27477297 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of CTNNB1 protein]
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]
tetramethylpyrazine results in decreased expression of CTNNB1 mRNA; tetramethylpyrazine results in decreased expression of CTNNB1 protein
CTD PMID:24961358, PMID:27477297 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases expression ISO tetramethylpyrazine results in increased expression of CYP11B1 mRNA CTD PMID:15520497 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein] CTD PMID:27477297 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
EXP
ISO
tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of FN1 mRNA]
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]
tetramethylpyrazine results in decreased expression of FN1 mRNA; tetramethylpyrazine results in decreased expression of FN1 protein
NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 protein]
CTD PMID:23022513, PMID:27477297, PMID:27837167 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [tetramethylpyrazine affects the expression of FOS mRNA] which results in decreased susceptibility to Methylnitrosourea CTD PMID:16268501 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO tetramethylpyrazine analog results in increased expression of GCLC mRNA; tetramethylpyrazine analog results in increased expression of GCLC protein
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]
CTD PMID:25056784, PMID:27477297 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein] CTD PMID:27477297 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein] CTD PMID:24200859 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in increased expression of HAVCR1 protein] CTD PMID:24200859 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein] CTD PMID:27837167 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO tetramethylpyrazine analog results in increased expression of HMOX1 mRNA; tetramethylpyrazine analog results in increased expression of HMOX1 protein; tetramethylpyrazine results in increased expression of HMOX1 mRNA
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; tetramethylpyrazine results in increased expression of and results in increased activity of HMOX1 protein
CTD PMID:18842672, PMID:25056784, PMID:26404762 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein] CTD PMID:27477297 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il6 interleukin 6 multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] CTD PMID:27477297 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
[tetramethylpyrazine affects the expression of JUN mRNA] which results in decreased susceptibility to Methylnitrosourea
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of JUN protein modified form]
CTD PMID:16268501, PMID:26404762 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein] CTD PMID:26404762 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:26404762 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein] CTD PMID:26404762 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein] CTD PMID:26404762 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of MPO protein] CTD PMID:22200888 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects response to substance
increases response to substance
increases expression
ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]
NFE2L2 affects the susceptibility to tetramethylpyrazine
NFE2L2 protein results in increased susceptibility to tetramethylpyrazine
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]
tetramethylpyrazine analog results in increased expression of NFE2L2 protein; tetramethylpyrazine results in increased expression of NFE2L2 mRNA; tetramethylpyrazine results in increased expression of NFE2L2 protein
CTD PMID:25056784, PMID:26404762, PMID:27477297, PMID:27837167 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO
tetramethylpyrazine inhibits the reaction [Methylnitrosourea results in increased expression of NFKBIA protein]
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]
CTD PMID:15960898, PMID:27477297 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein] CTD PMID:27477297 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP
ISO
tetramethylpyrazine results in increased expression of NOS2 mRNA
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of NOS2 mRNA]
CTD PMID:15528953, PMID:22200888 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO tetramethylpyrazine results in increased expression of NR1H3 mRNA CTD PMID:28034800 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:26404762 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP
ISO
tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB mRNA]; tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB protein]
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]
CTD PMID:23022513, PMID:27477297 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein] CTD PMID:27837167 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
EXP
ISO
tetramethylpyrazine results in increased expression of PPARG protein
tetramethylpyrazine results in increased expression of PPARG mRNA
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of PPARG protein]
CTD PMID:22200888, PMID:23022513, PMID:28034800 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]
CTD PMID:22200888, PMID:24961358 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]; tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of RELA mRNA]
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of RELA protein modified form]
tetramethylpyrazine promotes the reaction [Methylnitrosourea affects the localization of RELA protein]
CTD PMID:15960898, PMID:22200888, PMID:24961358, PMID:27837167 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein] CTD PMID:27837167 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srrt serrate, RNA effector molecule multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of SRRT protein] CTD PMID:26404762 NCBI chr12:22,457,898...22,471,090 JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein] CTD PMID:27477297 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of TIMP1 protein] CTD PMID:23022513 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]; tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]
tetramethylpyrazine inhibits the reaction [TNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]]
CTD PMID:17132701, PMID:22200888, PMID:24961358, PMID:27477297, PMID:27837167 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        inhibitor 18238
          apoptosis inhibitor 6785
            tetramethylpyrazine 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19483
                              organic cyclic compound 19252
                                organic heterocyclic compound 18422
                                  organic heteromonocyclic compound 16461
                                    diazines 12156
                                      pyrazines 1037
                                        tetramethylpyrazine 52
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.