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ONTOLOGY REPORT - ANNOTATIONS


Term:venetoclax
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Accession:CHEBI:133021 term browser browse the term
Definition:A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.
Synonyms:exact_synonym: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-(3-nitro-4-{[(oxan-4-yl)methyl]amino}benzene-1-sulfonyl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
 related_synonym: ABT 199;   ABT199;   Formula=C45H50ClN7O7S;   GDC 0199;   InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54);   InChIKey=LQBVNQSMGBZMKD-UHFFFAOYSA-N;   SMILES=C1N(CCN(C1)C2=CC=C(C(NS(C3=CC=C(C(=C3)[N+](=O)[O-])NCC4CCOCC4)(=O)=O)=O)C(=C2)OC=5C=C6C(=NC5)NC=C6)CC=7CCC(CC7C=8C=CC(=CC8)Cl)(C)C;   Venclexta
 xref: CAS:1257044-40-8 "ChemIDplus";   CAS:1257044-40-8 "KEGG DRUG";   Drug_Central:5133 "DrugCentral";   KEGG:D10679
 xref_mesh: MESH:C579720
 xref: PMID:24794804 "Europe PMC";   PMID:25185206 "Europe PMC";   PMID:25658896 "Europe PMC";   PMID:25768998 "Europe PMC";   PMID:25829398 "Europe PMC";   PMID:25882699 "Europe PMC";   PMID:25957396 "Europe PMC";   PMID:26110568 "Europe PMC";   PMID:26467384 "Europe PMC";   PMID:26493374 "Europe PMC";   PMID:26516589 "Europe PMC";   PMID:26565405 "Europe PMC";   PMID:26589495 "Europe PMC";   PMID:26711339 "Europe PMC";   PMID:26927160 "Europe PMC";   PMID:26967820 "Europe PMC";   PMID:27030982 "Europe PMC";   PMID:27056887 "Europe PMC";   PMID:27092880 "Europe PMC";   PMID:27095788 "Europe PMC";   PMID:27103402 "Europe PMC";   PMID:27166183 "Europe PMC";   PMID:27283158 "Europe PMC";   PMID:27466751 "Europe PMC";   PMID:27480872 "Europe PMC";   Reaxys:20908256 "Reaxys";   Wikipedia:Venetoclax


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venetoclax term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        inhibitor 18059
          B-cell lymphoma 2 inhibitor 1
            venetoclax 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            inorganic hydride 17104
                              pnictogen hydride 17062
                                nitrogen hydride 16885
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        tertiary amino compound 8521
                                          N-alkylpiperazine 2953
                                            venetoclax 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.