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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulfapyridine
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Accession:CHEBI:132842 term browser browse the term
Definition:A sulfonamide consisting of pyridine with a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms:related_synonym: 2-(p-Aminobenzenesulphonamido)pyridine;   2-Sulfanilamidopyridin;   2-Sulfanilamidopyridine;   2-Sulfanilylaminopyridine;   2-Sulfapyridine;   4-(2-Pyridinylsulfonyl)aniline;   4-Amino-N,2-pyridinylbenzenesulfonamide;   4-Amino-N-pyridin-2-yl-benzenesulfonamide;   4-[(2-Pyridylamino)sulfonyl]aniline;   Formula=C11H11N3O2S;   InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14);   InChIKey=GECHUMIMRBOMGK-UHFFFAOYSA-N;   N(1)-2-Pyridylsulfanilamide;   N(1)-Pyridylsulfanilamide;   N-2-Pyridylsulfanilamide;   SMILES=Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1;   Solfapiridina;   Sulphapyridine;   sulfapiridina;   sulfapyridinum
 xref: Beilstein:222065;   CAS:144-83-2;   DrugBank:DB00891;   Drug_Central:2524;   Gmelin:219135;   HMDB:HMDB0015028;   KEGG:D02434;   LINCS:LSM-5531
 xref_mesh: MESH:D013427
 xref: PMID:11431418;   PMID:17964793;   PMID:6136612;   PMID:6993682;   PMID:7021831;   Patent:GB512145;   Patent:US2275354;   Reaxys:222065;   VSDB:1922;   Wikipedia:Sulfapyridine

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sulfapyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G R Abcg2 ATP binding cassette subfamily G member 2 affects transport
increases transport		 ISO ABCG2 gene polymorphism affects the transport of Sulfapyridine
ABCG2 protein results in increased transport of Sulfapyridine		 CTD PMID:18167504 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G M Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) affects transport
increases transport		 ISO ABCG2 gene polymorphism affects the transport of Sulfapyridine
ABCG2 protein results in increased transport of Sulfapyridine		 CTD PMID:18167504 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G H ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) affects transport
increases transport		 EXP ABCG2 gene polymorphism affects the transport of Sulfapyridine
ABCG2 protein results in increased transport of Sulfapyridine		 CTD PMID:18167504 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G R Ccl2 C-C motif chemokine ligand 2 decreases secretion ISO Sulfapyridine results in decreased secretion of CCL2 protein CTD PMID:12231210 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G M Ccl2 chemokine (C-C motif) ligand 2 decreases secretion ISO Sulfapyridine results in decreased secretion of CCL2 protein CTD PMID:12231210 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G H CCL2 C-C motif chemokine ligand 2 decreases secretion EXP Sulfapyridine results in decreased secretion of CCL2 protein CTD PMID:12231210 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G R Cxcl1 C-X-C motif chemokine ligand 1 decreases secretion ISO Sulfapyridine results in decreased secretion of CXCL1 protein CTD PMID:12231210 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G M Cxcl1 chemokine (C-X-C motif) ligand 1 decreases secretion ISO Sulfapyridine results in decreased secretion of CXCL1 protein CTD PMID:12231210 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G H CXCL1 C-X-C motif chemokine ligand 1 decreases secretion EXP Sulfapyridine results in decreased secretion of CXCL1 protein CTD PMID:12231210 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G M Cxcl15 chemokine (C-X-C motif) ligand 15 decreases secretion ISO Sulfapyridine results in decreased secretion of CXCL8 protein CTD PMID:12231210 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G R Cxcl3 C-X-C motif chemokine ligand 3 decreases secretion ISO Sulfapyridine results in decreased secretion of CXCL1 protein CTD PMID:12231210 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G M Cxcl3 chemokine (C-X-C motif) ligand 3 decreases secretion ISO Sulfapyridine results in decreased secretion of CXCL1 protein CTD PMID:12231210 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G H CXCL8 C-X-C motif chemokine ligand 8 decreases secretion EXP Sulfapyridine results in decreased secretion of CXCL8 protein CTD PMID:12231210 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G R Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfapyridine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G M Hmbs hydroxymethylbilane synthase decreases activity ISO Sulfapyridine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525 		JBrowse link
G H HMBS hydroxymethylbilane synthase decreases activity ISO Sulfapyridine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G R Ifng interferon gamma multiple interactions ISO Sulfapyridine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G M Ifng interferon gamma multiple interactions EXP Sulfapyridine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G H IFNG interferon gamma multiple interactions ISO Sulfapyridine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G R Il12b interleukin 12B multiple interactions ISO Sulfapyridine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G M Il12b interleukin 12b multiple interactions EXP Sulfapyridine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G H IL12B interleukin 12B multiple interactions ISO Sulfapyridine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G R Nat2 N-acetyltransferase 2 increases acetylation
affects acetylation		 ISO NAT2 protein results in increased acetylation of Sulfapyridine
NAT2 gene polymorphism affects the acetylation of Sulfapyridine		 CTD PMID:18167504 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G M Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) increases acetylation
affects acetylation		 ISO NAT2 protein results in increased acetylation of Sulfapyridine
NAT2 gene polymorphism affects the acetylation of Sulfapyridine		 CTD PMID:18167504 NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236 		JBrowse link
G H NAT2 N-acetyltransferase 2 affects acetylation
increases acetylation		 EXP NAT2 gene polymorphism affects the acetylation of Sulfapyridine
NAT2 protein results in increased acetylation of Sulfapyridine		 CTD PMID:18167504 NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218 		JBrowse link
G R Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Sulfapyridine results in increased expression of TIMP2 mRNA CTD PMID:10743803 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G M Timp2 tissue inhibitor of metalloproteinase 2 increases expression ISO Sulfapyridine results in increased expression of TIMP2 mRNA CTD PMID:10743803 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,895...118,246,566 		JBrowse link
G H TIMP2 TIMP metallopeptidase inhibitor 2 increases expression EXP Sulfapyridine results in increased expression of TIMP2 mRNA CTD PMID:10743803 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387 		JBrowse link
G R Tnf tumor necrosis factor multiple interactions
decreases secretion		 ISO
EXP		 Sulfapyridine inhibits the reaction [Endotoxins results in increased expression of TNF protein]
Sulfapyridine results in decreased secretion of TNF protein		 CTD PMID:7496871 PMID:8598465 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G M Tnf tumor necrosis factor multiple interactions
decreases secretion		 ISO Sulfapyridine inhibits the reaction [Endotoxins results in increased expression of TNF protein]
Sulfapyridine results in decreased secretion of TNF protein		 CTD PMID:7496871 PMID:8598465 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G H TNF tumor necrosis factor multiple interactions
decreases secretion		 EXP
ISO		 Sulfapyridine inhibits the reaction [Endotoxins results in increased expression of TNF protein]
Sulfapyridine results in decreased secretion of TNF protein		 CTD PMID:7496871 PMID:8598465 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 73050
    role 72883
      biological role 72856
        xenobiotic 58451
          sulfapyridine 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 73050
    subatomic particle 73003
      composite particle 73003
        hadron 73003
          baryon 73003
            nucleon 73003
              atomic nucleus 73003
                atom 73003
                  main group element atom 72655
                    main group molecular entity 72654
                      s-block molecular entity 71286
                        hydrogen molecular entity 70807
                          hydrides 67375
                            inorganic hydride 57422
                              pnictogen hydride 57318
                                nitrogen hydride 56851
                                  azane 56242
                                    ammonia 56239
                                      organic amino compound 56130
                                        aromatic amine 46196
                                          anilines 42782
                                            substituted aniline 41714
                                              sulfanilamide 809
                                                sulfapyridine 31
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