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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfapyridine
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Accession:CHEBI:132842 term browser browse the term
Definition:A sulfonamide consisting of pyridine with a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms:related_synonym: 2-(p-Aminobenzenesulphonamido)pyridine;   2-Sulfanilamidopyridin;   2-Sulfanilamidopyridine;   2-Sulfanilylaminopyridine;   2-Sulfapyridine;   4-(2-Pyridinylsulfonyl)aniline;   4-Amino-N,2-pyridinylbenzenesulfonamide;   4-Amino-N-pyridin-2-yl-benzenesulfonamide;   4-[(2-Pyridylamino)sulfonyl]aniline;   Formula=C11H11N3O2S;   InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14);   InChIKey=GECHUMIMRBOMGK-UHFFFAOYSA-N;   N(1)-2-Pyridylsulfanilamide;   N(1)-Pyridylsulfanilamide;   N-2-Pyridylsulfanilamide;   SMILES=Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1;   Solfapiridina;   Sulphapyridine;   sulfapiridina;   sulfapyridinum
 xref: Beilstein:222065;   CAS:144-83-2;   DrugBank:DB00891;   Drug_Central:2524;   Gmelin:219135;   HMDB:HMDB0015028;   KEGG:D02434;   LINCS:LSM-5531
 xref_mesh: MESH:D013427
 xref: PMID:11431418;   PMID:17964793;   PMID:6136612;   PMID:6993682;   PMID:7021831;   Patent:GB512145;   Patent:US2275354;   Reaxys:222065;   VSDB:1922;   Wikipedia:Sulfapyridine



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sulfapyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
increases transport
ISO ABCG2 gene polymorphism affects the transport of Sulfapyridine
ABCG2 protein results in increased transport of Sulfapyridine
CTD PMID:18167504 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases secretion ISO Sulfapyridine results in decreased secretion of CCL2 protein CTD PMID:12231210 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases secretion ISO Sulfapyridine results in decreased secretion of CXCL1 protein CTD PMID:12231210 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases secretion ISO Sulfapyridine results in decreased secretion of CXCL1 protein CTD PMID:12231210 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfapyridine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Ifng interferon gamma multiple interactions ISO Sulfapyridine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Sulfapyridine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects acetylation
ISO NAT2 protein results in increased acetylation of Sulfapyridine
NAT2 gene polymorphism affects the acetylation of Sulfapyridine
CTD PMID:18167504 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Sulfapyridine results in increased expression of TIMP2 mRNA CTD PMID:10743803 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO
EXP
Sulfapyridine inhibits the reaction [Endotoxins results in increased expression of TNF protein]
Sulfapyridine results in decreased secretion of TNF protein
CTD PMID:7496871 PMID:8598465 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19887
      biological role 19885
        xenobiotic 18773
          sulfapyridine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19909
          baryon 19909
            nucleon 19909
              atomic nucleus 19909
                atom 19909
                  main group element atom 19859
                    main group molecular entity 19859
                      s-block molecular entity 19692
                        hydrogen molecular entity 19678
                          hydrides 19156
                            inorganic hydride 18129
                              pnictogen hydride 18118
                                nitrogen hydride 18021
                                  azane 17822
                                    ammonia 17821
                                      organic amino compound 17821
                                        aromatic amine 15425
                                          anilines 14437
                                            substituted aniline 14077
                                              sulfanilamide 2920
                                                sulfapyridine 10
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