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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfapyridine
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Accession:CHEBI:132842 term browser browse the term
Definition:A sulfonamide consisting of pyridine with a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms:related_synonym: 2-(p-Aminobenzenesulphonamido)pyridine;   2-Sulfanilamidopyridin;   2-Sulfanilamidopyridine;   2-Sulfanilylaminopyridine;   2-Sulfapyridine;   4-(2-Pyridinylsulfonyl)aniline;   4-Amino-N,2-pyridinylbenzenesulfonamide;   4-Amino-N-pyridin-2-yl-benzenesulfonamide;   4-[(2-Pyridylamino)sulfonyl]aniline;   Formula=C11H11N3O2S;   InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14);   InChIKey=GECHUMIMRBOMGK-UHFFFAOYSA-N;   N(1)-2-Pyridylsulfanilamide;   N(1)-Pyridylsulfanilamide;   N-2-Pyridylsulfanilamide;   SMILES=Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1;   Solfapiridina;   Sulphapyridine;   sulfapiridina;   sulfapyridinum
 xref: Beilstein:222065;   CAS:144-83-2;   DrugBank:DB00891;   Drug_Central:2524;   Gmelin:219135;   HMDB:HMDB0015028;   KEGG:D02434;   LINCS:LSM-5531
 xref_mesh: MESH:D013427
 xref: PMID:11431418;   PMID:17964793;   PMID:6136612;   PMID:6993682;   PMID:7021831;   Patent:GB512145;   Patent:US2275354;   Reaxys:222065;   VSDB:1922;   Wikipedia:Sulfapyridine


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sulfapyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
increases transport
ISO ABCG2 gene polymorphism affects the transport of Sulfapyridine
ABCG2 protein results in increased transport of Sulfapyridine
CTD PMID:18167504 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases secretion ISO Sulfapyridine results in decreased secretion of CCL2 protein CTD PMID:12231210 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases secretion ISO Sulfapyridine results in decreased secretion of CXCL1 protein CTD PMID:12231210 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases secretion ISO Sulfapyridine results in decreased secretion of CXCL1 protein CTD PMID:12231210 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfapyridine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Ifng interferon gamma multiple interactions ISO Sulfapyridine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Sulfapyridine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects acetylation
ISO NAT2 protein results in increased acetylation of Sulfapyridine
NAT2 gene polymorphism affects the acetylation of Sulfapyridine
CTD PMID:18167504 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Sulfapyridine results in increased expression of TIMP2 mRNA CTD PMID:10743803 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO
EXP
Sulfapyridine inhibits the reaction [Endotoxins results in increased expression of TNF protein]
Sulfapyridine results in decreased secretion of TNF protein
CTD PMID:7496871, PMID:8598465 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        xenobiotic 18381
          sulfapyridine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        aromatic amine 13618
                                          anilines 12329
                                            substituted aniline 11825
                                              sulfanilamide 245
                                                sulfapyridine 10
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