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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:roxadustat
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Accession:CHEBI:132774 term browser browse the term
Definition:An N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid. It is an inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH).
Synonyms:exact_synonym: N-[(4-hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]glycine
 related_synonym: ASP1517;   FG 4592;   FG4592;   Formula=C19H16N2O5;   HIF prolyl-hydroxylase inhibitor;   InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23);   InChIKey=YOZBGTLTNGAVFU-UHFFFAOYSA-N;   SMILES=O(C=1C=CC2=C(C1)C(=NC(=C2O)C(NCC(O)=O)=O)C)C=3C=CC=CC3;   roxadustatum
 xref: CAS:808118-40-3;   KEGG:D10593
 xref_mesh: MESH:C584543
 xref: PMID:26238121;   PMID:26494833;   PMID:26707978;   PMID:26808067;   PMID:26846333;   PMID:26947173;   PMID:27021233;   PMID:27082295;   PMID:27091985;   PMID:27094610;   PMID:27352308;   Reaxys:23352808


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roxadustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of ATG5 protein] CTD PMID:27082295 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of BNIP3 protein] CTD PMID:27082295 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity		 ISO
EXP		 [Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein]
roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein]		 CTD PMID:27082295 PMID:29741670 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hk2 hexokinase 2 increases expression ISO roxadustat results in increased expression of HK2 mRNA CTD PMID:33596451 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO roxadustat results in increased expression of LDHA mRNA CTD PMID:33596451 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of MAP1LC3B protein] CTD PMID:27082295 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO roxadustat results in increased expression of SLC2A1 mRNA CTD PMID:33596451 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        molecular messenger 18650
          neurotransmitter 11521
            glycine 3042
              glycine derivative 3032
                N-acylglycine 30
                  roxadustat 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    main group molecular entity 19759
                      s-block molecular entity 19628
                        hydrogen molecular entity 19614
                          hydrides 19087
                            inorganic hydride 18091
                              pnictogen hydride 18080
                                nitrogen hydride 17987
                                  azane 17796
                                    ammonia 17795
                                      organic amino compound 17795
                                        amino acid 15943
                                          alpha-amino acid 13846
                                            L-alpha-amino acid 12846
                                              serine family amino acid 5527
                                                glycine 3042
                                                  glycine derivative 3032
                                                    N-acylglycine 30
                                                      roxadustat 7
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