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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethyl trans-caffeate
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Accession:CHEBI:132714 term browser browse the term
Definition:An ethyl ester resulting from the formal condensation of the carboxy group of trans-caffeic acid with ethanol.
Synonyms:exact_synonym: ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
 related_synonym: (E)-ethyl 3,4-dihydroxycinnamate;   (E)-ethyl 3-(3,4-dihydroxyphenyl)acrylate;   (E)-ethyl caffeate;   Formula=C11H12O4;   InChI=1S/C11H12O4/c1-2-15-11(14)6-4-8-3-5-9(12)10(13)7-8/h3-7,12-13H,2H2,1H3/b6-4+;   InChIKey=WDKYDMULARNCIS-GQCTYLIASA-N;   SMILES=C=1(C=CC(=C(C1)O)O)/C=C/C(OCC)=O;   ethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate;   ethyl 3,4-dihydroxycinnamate;   ethyl caffeate
 xref: CAS:102-37-4
 xref_mesh: MESH:C032773
 xref: PMID:16041399;   PMID:19813225;   PMID:23050660;   PMID:24892518;   PMID:7334427;   Pubchem:5317238;   Reaxys:2106401;   Wikipedia:Ethyl_caffeate


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ethyl trans-caffeate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ethyl caffeate affects the phosphorylation of and affects the activity of AKT1 protein CTD PMID:24892518 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cdh2 cadherin 2 affects expression ISO ethyl caffeate affects the expression of CDH2 protein CTD PMID:24892518 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression ISO ethyl caffeate affects the expression of CDK2 protein CTD PMID:24892518 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 affects expression ISO ethyl caffeate affects the expression of CDK4 protein CTD PMID:24892518 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects expression
multiple interactions		 ISO ethyl caffeate affects the expression of ERBB2 protein
ethyl caffeate affects the phosphorylation of and affects the activity of ERBB2 protein		 CTD PMID:24892518 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO ethyl caffeate affects the expression of FGFR1 protein CTD PMID:24892518 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Ilk integrin-linked kinase affects expression ISO ethyl caffeate affects the expression of ILK protein CTD PMID:24892518 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Itga3 integrin subunit alpha 3 multiple interactions ISO ethyl caffeate affects the expression of [ITGA3 protein binds to ITGB1 protein] CTD PMID:24892518 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO ethyl caffeate affects the expression of [ITGA3 protein binds to ITGB1 protein] CTD PMID:24892518 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Kdr kinase insert domain receptor affects expression ISO ethyl caffeate affects the expression of KDR protein CTD PMID:24892518 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO ethyl caffeate affects the phosphorylation of and affects the activity of MAPK1 protein CTD PMID:24892518 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO ethyl caffeate affects the phosphorylation of and affects the activity of MAPK3 protein CTD PMID:24892518 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation ISO ethyl caffeate affects the phosphorylation of RB1 protein CTD PMID:24892518 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      application 19615
        anti-inflammatory agent 16506
          ethyl trans-caffeate 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic group 18902
                              organic divalent group 18884
                                organodiyl group 18884
                                  carbonyl group 18850
                                    carbonyl compound 18850
                                      carboxylic acid 18564
                                        monocarboxylic acid 17898
                                          alpha,beta-unsaturated monocarboxylic acid 13200
                                            cinnamic acids 2484
                                              hydroxycinnamic acid 1338
                                                caffeic acid 580
                                                  trans-caffeic acid 276
                                                    ethyl trans-caffeate 13
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