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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:icajine
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Accession:CHEBI:132668 term browser browse the term
Definition:A monoterpenoid indole alkaloid with formula C22H24N2O3, originallly isolated from the leaves of Strychnos icaja.
Synonyms:exact_synonym: (4aR,6aS,12aS,12bR,12cS)-15-methyl-4a,5,12,12a,12b,12c-hexahydro-11H-6a,4-(ethanoiminomethano)-1-oxa-10b-azacyclohepta[1,2,3-cd]fluoranthene-6,11(2H)-dione
 related_synonym: 19-methyl-16,19-seco-strychnidine-10,16-dione;   Formula=C22H24N2O3;   InChI=1S/C22H24N2O3/c1-23-8-7-22-15-4-2-3-5-16(15)24-19(26)11-17-20(21(22)24)14(10-18(22)25)13(12-23)6-9-27-17/h2-6,14,17,20-21H,7-12H2,1H3/t14-,17-,20-,21-,22+/m0/s1;   InChIKey=RNZRHJNFQWMXHB-ZXXLSYNSSA-N;   SMILES=[C@@]123[C@@]4([C@]5([C@@](CC1=O)(C(CN(CC2)C)=CCO[C@]5(CC(N4C6=C3C=CC=C6)=O)[H])[H])[H])[H]
 xref: CAS:5525-31-5
 xref_mesh: MESH:C438914
 xref: PMID:11509972;   PMID:15280006;   PMID:16317898;   PMID:19235686;   PMID:21616062;   PMID:21756423;   PMID:25594733;   PMID:4954818;   PMID:7779278;   PMID:7912074;   Reaxys:1093794;   Reaxys:59544


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icajine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 multiple interactions ISO icajine binds to and results in decreased activity of SCN5A protein CTD PMID:21616062 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        biophysical role 12651
          membrane transport modulator 12450
            sodium channel modulator 5042
              sodium channel blocker 3745
                icajine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                lactam 8032
                                                  delta-lactam 1196
                                                    icajine 1
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