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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:icajine
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Accession:CHEBI:132668 term browser browse the term
Definition:A monoterpenoid indole alkaloid with formula C22H24N2O3, originallly isolated from the leaves of Strychnos icaja.
Synonyms:exact_synonym: (4aR,6aS,12aS,12bR,12cS)-15-methyl-4a,5,12,12a,12b,12c-hexahydro-11H-6a,4-(ethanoiminomethano)-1-oxa-10b-azacyclohepta[1,2,3-cd]fluoranthene-6,11(2H)-dione
 related_synonym: 19-methyl-16,19-seco-strychnidine-10,16-dione;   Formula=C22H24N2O3;   InChI=1S/C22H24N2O3/c1-23-8-7-22-15-4-2-3-5-16(15)24-19(26)11-17-20(21(22)24)14(10-18(22)25)13(12-23)6-9-27-17/h2-6,14,17,20-21H,7-12H2,1H3/t14-,17-,20-,21-,22+/m0/s1;   InChIKey=RNZRHJNFQWMXHB-ZXXLSYNSSA-N;   SMILES=[C@@]123[C@@]4([C@]5([C@@](CC1=O)(C(CN(CC2)C)=CCO[C@]5(CC(N4C6=C3C=CC=C6)=O)[H])[H])[H])[H]
 xref: CAS:5525-31-5
 xref_mesh: MESH:C438914
 xref: PMID:11509972;   PMID:15280006;   PMID:16317898;   PMID:19235686;   PMID:21616062;   PMID:21756423;   PMID:25594733;   PMID:4954818;   PMID:7779278;   PMID:7912074;   Reaxys:1093794;   Reaxys:59544


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icajine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 multiple interactions ISO icajine binds to and results in decreased activity of SCN5A protein CTD PMID:21616062 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biophysical role 13092
          membrane transport modulator 12905
            sodium channel modulator 6388
              sodium channel blocker 4607
                icajine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                lactam 8302
                                                  delta-lactam 1200
                                                    icajine 1
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