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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:TRPM4 channel inhibitor
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Accession:CHEBI:132608 term browser browse the term
Definition:An inhibitor of transient receptor potential cation channel subfamily M member 4.
Synonyms:related_synonym: TRPM4 channel inhibitors;   Transient receptor potential cation channel subfamily M member 4 inhibitor;   Transient receptor potential cation channel subfamily M member 4 inhibitors;   melastatin 4 inhibitor;   melastatin 4 inhibitors
 xref: Wikipedia:TRPM4


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9-phenanthrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions EXP 9-phenanthrol inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G C3 complement C3 increases expression ISO 9-phenanthrol results in increased expression of C3 mRNA CTD PMID:22989670 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases abundance
multiple interactions
ISO CYP1A1 protein results in increased abundance of 9-phenanthrol
[CYP1A1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CTD PMID:27137136 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases abundance
ISO [CYP1A2 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CYP1A2 protein results in increased abundance of 9-phenanthrol
CTD PMID:27137136 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases abundance
multiple interactions
ISO CYP1B1 protein results in increased abundance of 9-phenanthrol
[CYP1B1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CTD PMID:27137136 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions
ISO ESR2 protein binds to 9-phenanthrol
9-phenanthrol inhibits the reaction [ESR2 protein binds to Estradiol]
CTD PMID:22989670 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO 9-phenanthrol results in decreased expression of JAG1 mRNA CTD PMID:22989670 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO 9-phenanthrol results in increased expression of NRIP1 mRNA CTD PMID:22989670 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 multiple interactions ISO 9-phenanthrol inhibits the reaction [Arsenic Trioxide results in increased expression of TRPM4 protein] CTD PMID:31054354 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        inhibitor 18241
          TRPM4 channel inhibitor 9
            9-phenanthrol + 9
paths to the root