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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:TRPM4 channel inhibitor
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Accession:CHEBI:132608 term browser browse the term
Definition:An inhibitor of transient receptor potential cation channel subfamily M member 4.
Synonyms:related_synonym: TRPM4 channel inhibitors;   Transient receptor potential cation channel subfamily M member 4 inhibitor;   Transient receptor potential cation channel subfamily M member 4 inhibitors;   melastatin 4 inhibitor;   melastatin 4 inhibitors
 xref: Wikipedia:TRPM4



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9-phenanthrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano1 anoctamin 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Calcium results in increased activity of ANO1 protein] CTD PMID:25573456 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
JBrowse link
G Ar androgen receptor multiple interactions EXP
ISO
9-phenanthrol inhibits the reaction [Metribolone binds to AR protein]
9-phenanthrol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD PMID:3695475 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G C3 complement C3 increases expression ISO 9-phenanthrol results in increased expression of C3 mRNA CTD PMID:22989670 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases abundance
multiple interactions
ISO CYP1A1 protein results in increased abundance of 9-phenanthrol
[CYP1A1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CTD PMID:27137136 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases abundance
ISO [CYP1A2 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CYP1A2 protein results in increased abundance of 9-phenanthrol
CTD PMID:27137136 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases abundance
multiple interactions
ISO CYP1B1 protein results in increased abundance of 9-phenanthrol
[CYP1B1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CTD PMID:27137136 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions
increases abundance
ISO [CYP2A13 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CYP2A13 protein results in increased abundance of 9-phenanthrol
CTD PMID:27137136 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 9-phenanthrol binds to and results in decreased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions
ISO ESR2 protein binds to 9-phenanthrol
9-phenanthrol inhibits the reaction [ESR2 protein binds to Estradiol]
CTD PMID:22989670 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of FTH1 mRNA] CTD PMID:27246103 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Gcg glucagon multiple interactions EXP 9-phenanthrol inhibits the reaction [[GCG protein co-treated with Glucose] results in increased secretion of INS1 protein] CTD PMID:29098165 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of ICAM1 protein] CTD PMID:28214884 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ins1 insulin 1 multiple interactions
increases secretion
EXP 9-phenanthrol inhibits the reaction [[GCG protein co-treated with Glucose] results in increased secretion of INS1 protein]; 9-phenanthrol inhibits the reaction [Glucose results in increased secretion of INS1 protein]
9-phenanthrol results in increased secretion of INS1 protein
CTD PMID:29098165 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO 9-phenanthrol results in decreased expression of JAG1 mRNA CTD PMID:22989670 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein] CTD PMID:27246103 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:27246103 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 9-phenanthrol binds to and affects the activity of NR1I2 protein
9-phenanthrol binds to and results in increased activity of NR1I2 protein
CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO 9-phenanthrol results in increased expression of NRIP1 mRNA CTD PMID:22989670 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 9-phenanthrol binds to and affects the activity of PPARG protein
9-phenanthrol binds to and results in increased activity of PPARG protein
CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO 9-phenanthrol results in decreased activity of SCN5A protein mutant form CTD PMID:30153324 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Sele selectin E multiple interactions ISO 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of SELE protein] CTD PMID:28214884 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO 9-phenanthrol binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 9-phenanthrol binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 multiple interactions
decreases activity
ISO 9-phenanthrol inhibits the reaction [Arsenic Trioxide results in increased expression of TRPM4 protein]; 9-phenanthrol inhibits the reaction [Glutamic Acid results in increased activity of TRPM4 protein]; 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased expression of TRPM4 protein]
9-phenanthrol results in decreased activity of TRPM4 protein
CTD PMID:25047048 PMID:28214884 PMID:31054354 PMID:34335274 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
G Trpm5 transient receptor potential cation channel, subfamily M, member 5 decreases activity ISO 9-phenanthrol results in decreased activity of TRPM5 protein CTD PMID:18297105 NCBI chr 1:198,254,956...198,277,824
Ensembl chr 1:198,255,723...198,277,654
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of VCAM1 protein] CTD PMID:28214884 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

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  CHEBI ontology 19848
    role 19824
      biological role 19822
        inhibitor 18907
          TRPM4 channel inhibitor 26
            9-phenanthrol + 26
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