CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: perfluorobutanesulfonic acid
Accession: CHEBI:132446
browse the term
Definition: A perfluoroalkanesulfonic acid that is butane-1-sulfonic acid in which all of the hydrogens of the butyl group have been replaced by fluorines.
Synonyms: exact_synonym: nonafluorobutane-1-sulfonic acid
related_synonym: 1,1,2,2,3,3,4,4,4-nonafluoro-1-butanesulfonic acid; 1-perfluorobutanesulfonic acid; FC-98; Formula=C4HF9O3S; InChI=1S/C4HF9O3S/c5-1(6,3(9,10)11)2(7,8)4(12,13)17(14,15)16/h(H,14,15,16); InChIKey=JGTNAGYHADQMCM-UHFFFAOYSA-N; PFBS; SMILES=C(C(C(S(O)(=O)=O)(F)F)(F)F)(C(F)(F)F)(F)F; nonafluoro-1-butanesulfonic acid; nonafluorobutanesulfonic acid; perfluorobutane-1-sulfonic acid
xref: CAS:375-73-5
xref_mesh: MESH:C539348
xref: PMID:16433328; PMID:17917760; PMID:19059455; PMID:19429410; PMID:20451658; PMID:23441933; PMID:24238775; PMID:25268321; PMID:26360456; PMID:26610298; PMID:26780052; PMID:26889942; Patent:WO2011093371; Reaxys:1813588; Wikipedia:Perfluorobutanesulfonic_acid
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Abca1
ATP binding cassette subfamily A member 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of ABCA1 mRNA
CTD
PMID:35337807
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Acaca
acetyl-CoA carboxylase alpha
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of ACACA mRNA
CTD
PMID:30031040
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Acot2
acyl-CoA thioesterase 2
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of ACOT2 mRNA
CTD
PMID:35337807
NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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Acox1
acyl-CoA oxidase 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of ACOX1 mRNA
CTD
PMID:32534104
NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
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Acsl1
acyl-CoA synthetase long-chain family member 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of ACSL1 mRNA
CTD
PMID:21705711
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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Apoa4
apolipoprotein A4
decreases expression
EXP
perfluorobutanesulfonic acid results in decreased expression of APOA4 mRNA
CTD
PMID:22071372
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Apoa5
apolipoprotein A5
decreases expression
ISO
perfluorobutanesulfonic acid results in decreased expression of APOA5 mRNA
CTD
PMID:21705711
NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
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Apobec1
apolipoprotein B mRNA editing enzyme catalytic subunit 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of APOBEC1 mRNA
CTD
PMID:21705711
NCBI chr 4:155,800,030...155,828,515
Ensembl chr 4:155,800,887...155,827,390
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App
amyloid beta precursor protein
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of APP mRNA
CTD
PMID:33772556
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Bdh2
3-hydroxybutyrate dehydrogenase 2
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of BDH2 mRNA
CTD
PMID:35337807
NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
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Cd36
CD36 molecule
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of CD36 mRNA
CTD
PMID:21705711
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cebpa
CCAAT/enhancer binding protein alpha
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of CEBPA mRNA; perfluorobutanesulfonic acid results in increased expression of CEBPA protein
CTD
PMID:30031040
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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Cga
glycoprotein hormones, alpha polypeptide
multiple interactions
ISO
perfluorobutanesulfonic acid inhibits the reaction [Colforsin results in increased expression of CGA protein]
CTD
PMID:33144174
NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
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Ciao2a
cytosolic iron-sulfur assembly component 2A
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of CIAO2A mRNA
CTD
PMID:33772556
NCBI chr 8:66,670,533...66,682,455
Ensembl chr 8:66,670,483...66,682,455
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Crp
C-reactive protein
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of CRP mRNA
CTD
PMID:33772556
NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of CYP1A1 mRNA
CTD
PMID:32534104
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of CYP2B10 mRNA
CTD
PMID:32534104
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of CYP2B6 mRNA
CTD
PMID:35337807
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases activity
ISO
perfluorobutanesulfonic acid results in decreased activity of CYP2C19 protein
CTD
PMID:35121066
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of CYP3A4 mRNA
CTD
PMID:33772556
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of CYP7A1 mRNA
CTD
PMID:32534104
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Egr3
early growth response 3
multiple interactions
ISO
perfluorobutanesulfonic acid inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]
CTD
PMID:33111528
NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
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Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
increases expression multiple interactions
ISO EXP
perfluorobutanesulfonic acid results in increased expression of EHHADH mRNA perfluorobutanesulfonic acid affects the reaction [perfluorooctane sulfonic acid results in increased expression of EHHADH mRNA]
CTD
PMID:21705711 PMID:32534104 PMID:34695511 PMID:35337807
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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Esr1
estrogen receptor 1
affects binding
ISO
perfluorobutanesulfonic acid binds to [ESR1 protein binds to Estradiol]
CTD
PMID:33111528
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Fabp4
fatty acid binding protein 4
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of FABP4 mRNA
CTD
PMID:30031040 PMID:32534104
NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
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Fah
fumarylacetoacetate hydrolase
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of FAH mRNA
CTD
PMID:33772556
NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505
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Fasn
fatty acid synthase
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of FASN mRNA; perfluorobutanesulfonic acid results in increased expression of FASN protein
CTD
PMID:30031040 PMID:35337807
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Fdft1
farnesyl diphosphate farnesyl transferase 1
decreases expression
EXP
perfluorobutanesulfonic acid results in decreased expression of FDFT1 mRNA
CTD
PMID:22071372
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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Fgb
fibrinogen beta chain
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of FGB mRNA
CTD
PMID:33772556
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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Fgg
fibrinogen gamma chain
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of FGG mRNA
CTD
PMID:33772556
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
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Ggh
gamma-glutamyl hydrolase
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of GGH mRNA
CTD
PMID:33772556
NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787
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Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of GPAM mRNA
CTD
PMID:35337807
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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Gsta1
glutathione S-transferase alpha 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of GSTA1 mRNA
CTD
PMID:35337807
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
decreases expression increases expression
EXP ISO
perfluorobutanesulfonic acid results in decreased expression of HADHA mRNA perfluorobutanesulfonic acid results in increased expression of HADHA mRNA
CTD
PMID:22071372 PMID:33772556
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
increases expression
EXP
perfluorobutanesulfonic acid results in increased expression of HADHB mRNA
CTD
PMID:22071372
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
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Hhex
hematopoietically expressed homeobox
affects expression
EXP
perfluorobutanesulfonic acid affects the expression of HHEX mRNA
CTD
PMID:22071372
NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of HMGCS1 mRNA
CTD
PMID:35337807
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Itga1
integrin subunit alpha 1
affects expression
ISO
perfluorobutanesulfonic acid affects the expression of ITGA1 protein
CTD
PMID:33677611
NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
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Lhb
luteinizing hormone subunit beta
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of LHB protein
CTD
PMID:27803384
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
perfluorobutanesulfonic acid results in increased phosphorylation of MAPK1 protein
CTD
PMID:30031040
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
perfluorobutanesulfonic acid results in increased phosphorylation of MAPK3 protein
CTD
PMID:30031040
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mogat1
monoacylglycerol O-acyltransferase 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of MOGAT1 mRNA
CTD
PMID:32534104
NCBI chr 9:79,980,963...79,988,513
Ensembl chr 9:79,956,649...79,988,513
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Mttp
microsomal triglyceride transfer protein
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of MTTP mRNA
CTD
PMID:35337807
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity increases expression
ISO
perfluorobutanesulfonic acid results in increased activity of NFE2L2 protein perfluorobutanesulfonic acid results in increased expression of NFE2L2 mRNA
CTD
PMID:30114225 PMID:35337807
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of NR1I2 mRNA
CTD
PMID:35337807
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of NR1I3 mRNA
CTD
PMID:35337807
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Pax8
paired box 8
affects expression
EXP
perfluorobutanesulfonic acid affects the expression of PAX8 mRNA
CTD
PMID:22071372
NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363
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Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of PCK2 mRNA
CTD
PMID:35337807
NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
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Pdk4
pyruvate dehydrogenase kinase 4
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of PDK4 mRNA
CTD
PMID:32534104
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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Plin2
perilipin 2
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of PLIN2 mRNA
CTD
PMID:33772556
NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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Por
cytochrome p450 oxidoreductase
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of POR mRNA
CTD
PMID:33772556
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Ppara
peroxisome proliferator activated receptor alpha
increases expression affects binding increases activity
ISO
perfluorobutanesulfonic acid results in increased expression of PPARA mRNA perfluorobutanesulfonic acid binds to PPARA protein perfluorobutanesulfonic acid results in increased activity of PPARA protein
CTD
PMID:25689681 PMID:28857218 PMID:35337807 PMID:35752307
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression affects binding
ISO EXP
perfluorobutanesulfonic acid results in increased expression of PPARG mRNA; perfluorobutanesulfonic acid results in increased expression of PPARG protein perfluorobutanesulfonic acid binds to PPARG protein
CTD
PMID:30031040 PMID:35752307
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ptpn11
protein tyrosine phosphatase, non-receptor type 11
multiple interactions
ISO
perfluorobutanesulfonic acid binds to and results in decreased activity of PTPN11 protein
CTD
PMID:27572461
NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
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Scd
stearoyl-CoA desaturase
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of SCD mRNA
CTD
PMID:35337807
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Slc10a1
solute carrier family 10 member 1
increases transport
EXP ISO
SLC10A1 protein results in increased transport of perfluorobutanesulfonic acid
CTD
PMID:26001962
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc22a1
solute carrier family 22 member 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of SLC22A1 mRNA
CTD
PMID:33772556
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc51a
solute carrier family 51 subunit alpha
multiple interactions
ISO
[SLC51A protein binds to SLC51B protein] which results in increased transport of perfluorobutanesulfonic acid
CTD
PMID:26001962
NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
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Slc51b
solute carrier family 51 subunit beta
multiple interactions
ISO
[SLC51A protein binds to SLC51B protein] which results in increased transport of perfluorobutanesulfonic acid
CTD
PMID:26001962
NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
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Slco1a5
solute carrier organic anion transporter family, member 1A5
increases transport
EXP
SLCO1A5 protein results in increased transport of perfluorobutanesulfonic acid
CTD
PMID:28013215
NCBI chr 4:175,172,390...175,254,598
Ensembl chr 4:174,710,004...175,254,573
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Slco1b2
solute carrier organic anion transporter family member 1B2
increases transport
EXP ISO
SLCO1B2 protein results in increased transport of perfluorobutanesulfonic acid SLCO1B3 protein results in increased transport of perfluorobutanesulfonic acid
CTD
PMID:28013215
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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Sod1
superoxide dismutase 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of SOD1 mRNA
CTD
PMID:35337807
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Srebf1
sterol regulatory element binding transcription factor 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of SREBF1 mRNA
CTD
PMID:35337807
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Stat5b
signal transducer and activator of transcription 5B
decreases activity
ISO
perfluorobutanesulfonic acid results in decreased activity of STAT5B protein
CTD
PMID:30114225
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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Sult1b1
sulfotransferase family 1B member 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of SULT1B1 mRNA
CTD
PMID:33772556
NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
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Sult2a1
sulfotransferase family 2A member 1
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of SULT2A1 mRNA
CTD
PMID:35337807
NCBI chr 1:75,451,178...75,508,142
Ensembl chr 1:74,911,100...75,508,134
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Tff1
trefoil factor 1
multiple interactions
ISO
perfluorobutanesulfonic acid inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]
CTD
PMID:33111528
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Ttr
transthyretin
multiple interactions
ISO
perfluorobutanesulfonic acid affects the reaction [Thyroxine binds to TTR protein]
CTD
PMID:27528273
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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Ugt2b7
UDP glucuronosyltransferase family 2 member B7
increases expression
ISO
perfluorobutanesulfonic acid results in increased expression of UGT2B7 mRNA
CTD
PMID:33772556
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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