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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor
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Accession:CHEBI:132365 term browser browse the term
Definition:An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of procollagen-proline dioxygenase (EC 1.14.11.2).
Synonyms:related_synonym: EC 1.14.11.2 inhibitor;   EC 1.14.11.2 inhibitors;   collagen proline hydroxylase inhibitor;   collagen proline hydroxylase inhibitors;   peptidyl proline hydroxylase inhibitor;   peptidyl proline hydroxylase inhibitors;   procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitor;   procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitors;   procollagen-proline 4-dioxygenase inhibitor;   procollagen-proline 4-dioxygenase inhibitors;   procollagen-proline dioxygenase (EC 1.14.11.2) inhibitors;   procollagen-proline dioxygenase inhibitor;   procollagen-proline dioxygenase inhibitors;   procollagen-proline,2-oxoglutarate-4-dioxygenase inhibitor;   procollagen-proline,2-oxoglutarate-4-dioxygenase inhibitors;   proline hydroxylase inhibitor;   proline hydroxylase inhibitors;   proline protocollagen hydroxylase inhibitor;   proline protocollagen hydroxylase inhibitors;   proline, 2-oxoglutarate dioxygenase inhibitor;   proline, 2-oxoglutarate dioxygenase inhibitors;   proline,2-oxoglutarate 4-dioxygenase inhibitor;   proline,2-oxoglutarate 4-dioxygenase inhibitors;   prolyl 4-hydroxylase inhibitor;   prolyl 4-hydroxylase inhibitors;   prolyl hydroxylase inhibitor;   prolyl hydroxylase inhibitors;   prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating inhibitor;   prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating inhibitors;   prolylprotocollagen dioxygenase inhibitor;   prolylprotocollagen dioxygenase inhibitors;   prolylprotocollagen hydroxylase inhibitor;   prolylprotocollagen hydroxylase inhibitors;   protocollagen hydroxylase inhibitor;   protocollagen hydroxylase inhibitors;   protocollagen proline 4-hydroxylase inhibitor;   protocollagen proline 4-hydroxylase inhibitors;   protocollagen proline dioxygenase inhibitor;   protocollagen proline dioxygenase inhibitors;   protocollagen prolyl hydroxylase inhibitor;   protocollagen prolyl hydroxylase inhibitors
 xref: Wikipedia:Procollagen-proline_dioxygenase



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3,4-dihydroxybenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO protocatechuic acid inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein] CTD PMID:33497687 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased expression of AKR1B3 mRNA] CTD PMID:22687555 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Gallic Acid inhibits the reaction [protocatechuic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]]; protocatechuic acid inhibits the reaction [APP protein modified form binds to APP protein modified form] CTD PMID:22129351 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of BAX protein] CTD PMID:33497687 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
protocatechuic acid inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of BCL2 mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]
CTD PMID:18082360 PMID:33497687 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein] CTD PMID:33497687 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
protocatechuic acid inhibits the reaction [furan results in increased activity of CASP3 protein]; protocatechuic acid inhibits the reaction [Rotenone results in increased activity of CASP3 protein]
protocatechuic acid inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]
CTD PMID:18082360 PMID:32758512 PMID:33497687 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions EXP protocatechuic acid inhibits the reaction [furan results in increased activity of CASP9 protein] CTD PMID:32758512 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases activity
multiple interactions
EXP
ISO
protocatechuic acid results in increased activity of CAT protein
protocatechuic acid inhibits the reaction [furan results in decreased activity of CAT protein]
protocatechuic acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]
CTD PMID:29842870 PMID:32758512 PMID:33497687 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:31306686 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP protocatechuic acid results in increased expression of CDKN1A protein CTD PMID:16227210 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO
EXP
COMT protein results in increased methylation of protocatechuic acid CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cs citrate synthase increases activity ISO protocatechuic acid results in increased activity of CS protein CTD PMID:31306686 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein] CTD PMID:15302093 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein] CTD PMID:15302093 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
EXP [protocatechuic acid co-treated with Methylcholanthrene] results in decreased activity of CYP2E1 protein
protocatechuic acid results in decreased activity of CYP2E1 protein
CTD PMID:15302093 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Eno1 enolase 1 increases expression ISO protocatechuic acid results in increased expression of ENO1 mRNA CTD PMID:16227210 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Epo erythropoietin increases expression
multiple interactions
EXP protocatechuic acid results in increased expression of EPO protein
protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of EPO protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of EPO protein]
CTD PMID:31850806 PMID:32461003 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression
multiple interactions
EXP protocatechuic acid results in increased expression of FSHB protein
protocatechuic acid inhibits the reaction [furan results in decreased expression of FSHB protein]
CTD PMID:29842870 PMID:32758512 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
EXP protocatechuic acid results in increased activity of G6PD protein
protocatechuic acid inhibits the reaction [furan results in decreased activity of G6PD protein]
CTD PMID:29842870 PMID:32758512 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in decreased expression of and results in decreased activity of GLO1 protein] CTD PMID:22687555 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO protocatechuic acid results in increased expression of GPX1 mRNA
protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]
CTD PMID:33497687 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
increases activity
ISO protocatechuic acid inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of GSR mRNA]
protocatechuic acid results in increased expression of GSR mRNA
protocatechuic acid results in increased activity of GSR protein
CTD PMID:33497687 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases stability
increases expression
multiple interactions
EXP protocatechuic acid results in increased stability of HIF1A protein
protocatechuic acid results in increased expression of HIF1A protein
protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of HIF1A protein]
CTD PMID:16227210 PMID:31850806 PMID:32461003 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Il10 interleukin 10 multiple interactions EXP protocatechuic acid inhibits the reaction [furan results in decreased expression of IL10 protein] CTD PMID:32758512 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL1B protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]
protocatechuic acid inhibits the reaction [furan results in increased expression of IL1B protein]
CTD PMID:22687555 PMID:32758512 PMID:33497687 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:22687555 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ldhc lactate dehydrogenase C increases activity EXP protocatechuic acid results in increased activity of LDHC protein CTD PMID:29842870 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
multiple interactions
EXP protocatechuic acid results in increased expression of LHB protein
protocatechuic acid inhibits the reaction [furan results in decreased expression of LHB protein]
CTD PMID:29842870 PMID:32758512 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Mpo myeloperoxidase increases activity
decreases activity
multiple interactions
ISO
EXP
protocatechuic acid results in increased activity of MPO protein
protocatechuic acid results in decreased activity of MPO protein
protocatechuic acid inhibits the reaction [furan results in increased activity of MPO protein]
CTD PMID:24060682 PMID:29842870 PMID:32758512 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein] CTD PMID:20026373 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO protocatechuic acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of NOS2 mRNA]; protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] CTD PMID:20026373 PMID:31306686 PMID:33497687 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases activity
EXP [protocatechuic acid co-treated with Methylcholanthrene] results in increased activity of NQO1 protein
protocatechuic acid results in increased activity of NQO1 protein
CTD PMID:15302093 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Prl prolactin multiple interactions EXP protocatechuic acid inhibits the reaction [furan results in decreased expression of PRL protein] CTD PMID:32758512 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased expression of PTGS2 mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of PTGS2 protein]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of PTGS2 protein] CTD PMID:20026373 PMID:22687555 PMID:31306686 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased expression of and results in increased activity of RELA protein]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of RELA mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of RELA protein]; protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein] CTD PMID:20026373 PMID:22687555 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sele selectin E multiple interactions ISO protocatechuic acid inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:30611791 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression
multiple interactions
EXP protocatechuic acid results in increased expression of SLC2A1 protein
protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC2A1 protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of SLC2A1 protein]
CTD PMID:31850806 PMID:32461003 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]
protocatechuic acid results in increased expression of SOD2 mRNA
CTD PMID:33497687 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
protocatechuic acid inhibits the reaction [Galactose results in increased secretion of TNF protein]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
protocatechuic acid inhibits the reaction [furan results in increased expression of TNF protein]
protocatechuic acid inhibits the reaction [TNF protein results in increased expression of SELE protein]
CTD PMID:22687555 PMID:30611791 PMID:31306686 PMID:32758512 PMID:33497687 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
EXP protocatechuic acid results in increased expression of VEGFA protein
protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of VEGFA protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of VEGFA protein]
CTD PMID:16227210 PMID:31850806 PMID:32461003 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
ethyl 3,4-dihydroxybenzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp4 fatty acid binding protein 4 multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased expression of FABP4 mRNA] CTD PMID:24338020 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased ubiquitination of and results in increased degradation of GATA3 protein] CTD PMID:24338020 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Klf2 Kruppel-like factor 2 multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased ubiquitination of and results in increased degradation of KLF2 protein] CTD PMID:24338020 NCBI chr16:17,521,773...17,523,723
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased expression of PPARG mRNA] CTD PMID:24338020 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO ethyl protocatechuate inhibits the reaction [Ascorbic Acid results in increased expression of SP7 mRNA]; ethyl protocatechuate inhibits the reaction [Ascorbic Acid results in increased expression of SP7 protein] CTD PMID:21467157 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Tafazzin tafazzin, phospholipid-lysophospholipid transacylase multiple interactions ISO ethyl protocatechuate inhibits the reaction [Rosiglitazone results in increased ubiquitination of and results in increased degradation of TAFAZZIN protein] CTD PMID:24338020 NCBI chr  X:152,065,539...152,076,178
Ensembl chr  X:152,065,609...152,074,001
JBrowse link

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  CHEBI ontology 19823
    role 19773
      biological role 19773
        biochemical role 19390
          enzyme inhibitor 18395
            EC 1.* (oxidoreductase) inhibitor 16721
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 14308
                EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor 62
                  EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor 47
                    3,4-dihydroxybenzoic acid + 47
                    ethyl 3,4-dihydroxybenzoate 6
                    roxadustat 0
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