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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triptonide
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Accession:CHEBI:132267 term browser browse the term
Definition:A diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii.
Synonyms:exact_synonym: (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione
 related_synonym: Formula=C20H22O6;   InChI=1S/C20H22O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14H,4-7H2,1-3H3/t11-,12-,13-,14-,17-,18-,19+,20+/m0/s1;   InChIKey=SWOVVKGLGOOUKI-ZHGGVEMFSA-N;   SMILES=[C@]123[C@]4(CCC5=C([C@@]4(C[C@H]6[C@]3(C([C@@]7([C@H]([C@@H]1O2)O7)C(C)C)=O)O6)[H])COC5=O)C
 xref: CBA:292103
 xref_mesh: MESH:C084079
 xref: PMID:10774048;   PMID:12903464;   PMID:24346247;   PMID:25296383;   PMID:25308753;   PMID:5072337;   PMID:8237400;   PMID:9863222;   Pubchem:65411;   Reaxys:5313008


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triptonide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO triptonide results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:28666825 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO triptonide results in decreased expression of BCL2 protein CTD PMID:28666825 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases cleavage ISO triptonide results in increased cleavage of CASP3 protein CTD PMID:28666825 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO triptonide results in decreased expression of GLI1 mRNA; triptonide results in decreased expression of GLI1 protein CTD PMID:30610878 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases expression
multiple interactions
ISO triptonide results in decreased expression of LYN mRNA
triptonide results in decreased expression of and results in decreased phosphorylation of LYN protein
CTD PMID:28666825 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO triptonide results in decreased phosphorylation of MAPK1 protein CTD PMID:28666825 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO triptonide results in decreased phosphorylation of MAPK3 protein CTD PMID:28666825 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO triptonide results in increased cleavage of PARP1 protein CTD PMID:28666825 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptch1 patched 1 increases expression ISO triptonide results in increased expression of PTCH1 protein CTD PMID:30610878 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO triptonide results in decreased expression of SHH protein CTD PMID:30610878 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        anti-inflammatory agent 14950
          triptonide 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic ester 14077
                                        lactone 5979
                                          gamma-lactone 1214
                                            butenolide 361
                                              triptonide 10
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