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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxyquinone
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Accession:CHEBI:132130 term browser browse the term
Definition:Any quinone in which one or more of the carbons making up the quinone moiety is substituted by a hydroxy group.
Synonyms:related_synonym: hydroxyquinones


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Alkannin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] CTD PMID:30924981 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] CTD PMID:30924981 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of MPO protein] CTD PMID:30924981 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein] CTD PMID:30924981 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein] CTD PMID:30924981 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rho rhodopsin multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO mRNA]; alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO protein] CTD PMID:30924981 NCBI chr 4:147,832,136...147,837,298
Ensembl chr 4:147,832,136...147,837,298
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 mRNA]; alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 protein] CTD PMID:30924981 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 mRNA]; alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 protein] CTD PMID:30924981 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:30924981 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
atovaquone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity ISO Atovaquone results in increased activity of CYP1A2 protein CTD PMID:11124226 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP
Atovaquone results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Atovaquone inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
coenzyme Q10 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Atorvastatin results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein] CTD PMID:27087047 PMID:27345130 PMID:32383521 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases response to substance
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein] CTD PMID:22186599 PMID:32383521 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ARAP2 mRNA] CTD PMID:21370964 NCBI chr14:48,726,033...48,922,809
Ensembl chr14:48,726,045...48,922,983
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:27087047 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAK1 protein] CTD PMID:27087047 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:27087047 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP coenzyme Q10 results in increased expression of BCL2 mRNA
coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
CTD PMID:18817789 PMID:27087047 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein] CTD PMID:27087047 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G C1qa complement C1q A chain decreases expression ISO coenzyme Q10 results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C4b complement C4B (Chido blood group) decreases expression ISO coenzyme Q10 results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
CTD PMID:20510337 PMID:22186599 PMID:27087047 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP8 protein] CTD PMID:27087047 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein] CTD PMID:27087047 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP
ISO
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; [Quercetin co-treated with coenzyme Q10] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of CAT protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]
[Vitamin E co-treated with coenzyme Q10] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of CAT mRNA]
CTD PMID:12242689 PMID:19958828 PMID:25382014 PMID:29143438 PMID:29948670 PMID:33271250 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein] CTD PMID:27087047 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein] CTD PMID:27087047 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Ctss cathepsin S decreases expression ISO coenzyme Q10 results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein] CTD PMID:23640862 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of EPS15 mRNA] CTD PMID:21370964 NCBI chr 5:128,923,809...129,022,268
Ensembl chr 5:128,923,934...129,022,054
JBrowse link
G Etv3 ETS variant transcription factor 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ETV3 mRNA] CTD PMID:21370964 NCBI chr 2:186,872,483...186,887,294
Ensembl chr 2:186,872,520...186,886,592
JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FADD protein] CTD PMID:27087047 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Faslg Fas ligand multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FASLG protein] CTD PMID:27087047 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of FSHR mRNA] CTD PMID:31557371 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of G6PD protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein] CTD PMID:33548410 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO coenzyme Q10 results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
Chloroquine inhibits the reaction [coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]]; coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]
CTD PMID:27174133 PMID:33271250 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of GPX1 mRNA] CTD PMID:33271250 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein] CTD PMID:22186599 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of GSR protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein] CTD PMID:19958828 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA] CTD PMID:27174133 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein] CTD PMID:32383521 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein] CTD PMID:32383521 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 decreases abundance ISO KCNJ6 gene mutant form results in decreased abundance of coenzyme Q10 CTD PMID:15256069 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions
increases activity
EXP [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of LDHC protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]
coenzyme Q10 results in increased activity of LDHC protein
CTD PMID:33548410 NCBI chr 1:102,914,875...102,931,843
Ensembl chr 1:102,915,191...102,931,839
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:27087047 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP9 protein] CTD PMID:27087047 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of NCOA2 mRNA] CTD PMID:21370964 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 increases expression
multiple interactions
ISO coenzyme Q10 results in increased expression of NDUFB6 protein
coenzyme Q10 inhibits the reaction [Galactosamine results in decreased expression of NDUFB6 mRNA]
CTD PMID:19523936 NCBI chr 5:56,567,109...56,576,676
Ensembl chr 5:56,567,109...56,576,676
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 increases expression ISO coenzyme Q10 results in increased expression of NDUFS7 protein CTD PMID:19523936 NCBI chr 7:12,318,776...12,326,403
Ensembl chr 7:12,318,757...12,326,392
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP
ISO
coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA]
CTD PMID:27174133 PMID:33271250 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:20510337 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lamivudine results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in decreased phosphorylation of NOS3 protein] CTD PMID:23640862 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO coenzyme Q10 results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of PCNA mRNA] CTD PMID:31557371 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein] CTD PMID:22186599 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein] CTD PMID:33271250 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Pou2f1 POU class 2 homeobox 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of POU2F1 mRNA] CTD PMID:21370964 NCBI chr13:84,075,316...84,217,368
Ensembl chr13:84,083,632...84,217,366
JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PPP2R5C mRNA] CTD PMID:21370964 NCBI chr 6:134,804,128...134,941,912
Ensembl chr 6:134,804,141...134,939,358
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein] CTD PMID:33271250 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PSD3 mRNA] CTD PMID:21370964 NCBI chr16:23,212,165...23,789,414
Ensembl chr16:23,447,366...23,781,604
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO coenzyme Q10 results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:81,816,778...81,968,832
Ensembl chr 4:81,818,569...81,968,832
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Snca synuclein alpha multiple interactions ISO
EXP
coenzyme Q10 inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]
coenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]]
[coenzyme Q10 co-treated with Creatine] results in decreased expression of SNCA protein
CTD PMID:15114628 PMID:19476553 PMID:21843543 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod2 superoxide dismutase 2 affects expression
multiple interactions
EXP
ISO
coenzyme Q10 affects the expression of SOD2 protein
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of SOD2 mRNA]
coenzyme Q10 inhibits the reaction [Acrolein results in increased expression of SOD2 protein]
CTD PMID:22083459 PMID:24008411 PMID:33271250 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein] CTD PMID:33271250 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA] CTD PMID:27087047 PMID:27174133 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TNF protein]
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]
CTD PMID:20510337 PMID:32383521 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TRP53 protein] CTD PMID:20510337 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
embelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO embelin results in decreased phosphorylation of AKT1 protein CTD PMID:24694877 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein] CTD PMID:28722333 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein] CTD PMID:28722333 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO embelin results in increased expression of BAX protein CTD PMID:24694877 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO embelin results in decreased expression of BCL2 protein CTD PMID:24694877 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 increases expression ISO embelin results in increased expression of BECN1 protein CTD PMID:28722333 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases degradation
ISO embelin results in increased cleavage of CASP3 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP3 protein]
CTD PMID:24694877 PMID:28722333 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases degradation
multiple interactions
ISO embelin results in increased degradation of CASP9 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP9 protein]
CTD PMID:28722333 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP embelin inhibits the reaction [Paraquat results in decreased expression of CAT protein] CTD PMID:32020686 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO embelin results in decreased expression of CCND1 protein CTD PMID:24694877 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdh1 cadherin 1 increases expression ISO embelin results in increased expression of CDH1 protein CTD PMID:24694877 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO embelin results in decreased expression of CDK2 protein CTD PMID:24694877 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO embelin results in decreased expression of CDK6 protein CTD PMID:24694877 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases cleavage ISO embelin results in increased cleavage of DFFA protein CTD PMID:28722333 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO embelin results in decreased expression of GLI1 protein CTD PMID:24694877 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression ISO embelin results in decreased expression of GLI2 protein CTD PMID:24694877 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:32020686 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased expression of IL6 protein] CTD PMID:32020686 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO embelin results in decreased expression of KDR protein CTD PMID:24694877 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO embelin results in decreased expression of MKI67 protein CTD PMID:24694877 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO embelin results in decreased expression of MMP2 protein CTD PMID:24694877 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO embelin results in decreased expression of MMP9 protein CTD PMID:24694877 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO embelin results in increased cleavage of PARP1 protein
3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein]
CTD PMID:24694877 PMID:28722333 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO embelin results in decreased expression of PCNA protein CTD PMID:24694877 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO embelin results in decreased expression of PTGS2 protein CTD PMID:24694877 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein] CTD PMID:32020686 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO embelin results in decreased expression of SNAI1 protein CTD PMID:24694877 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO embelin results in decreased expression of SNAI2 protein CTD PMID:24694877 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Sqstm1 sequestosome 1 increases degradation ISO embelin results in increased degradation of SQSTM1 protein CTD PMID:28722333 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased expression of TNF protein] CTD PMID:32020686 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO embelin results in increased expression of TNFRSF10A protein CTD PMID:24694877 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO embelin results in decreased expression of VEGFA protein CTD PMID:24694877 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases activity
increases degradation
ISO embelin results in decreased activity of XIAP protein
embelin results in increased degradation of XIAP protein
CTD PMID:16339139 PMID:28722333 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO embelin results in decreased expression of ZEB1 protein CTD PMID:24694877 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
Ilimaquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ilimaquinone results in decreased expression of BCL2 protein CTD PMID:24930757 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO ilimaquinone results in decreased expression of BCL2L1 protein CTD PMID:24930757 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]
ilimaquinone results in increased cleavage of CASP3 protein
CTD PMID:24930757 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage ISO ilimaquinone results in increased cleavage of CASP8 protein CTD PMID:24930757 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA] CTD PMID:24930757 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO ilimaquinone results in increased phosphorylation of MAPK1 protein CTD PMID:24930757 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO ilimaquinone results in increased phosphorylation of MAPK3 protein CTD PMID:24930757 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
ilimaquinone results in increased cleavage of PARP1 protein
CTD PMID:24930757 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pld2 phospholipase D2 multiple interactions
increases activity
ISO 1-Butanol inhibits the reaction [ilimaquinone results in increased activity of PLD2 protein] CTD PMID:17897952 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]
ilimaquinone results in increased expression of TNFRSF10A mRNA; ilimaquinone results in increased expression of TNFRSF10A protein
CTD PMID:24930757 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:24930757 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
juglone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO juglone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
ISO [Indomethacin co-treated with juglone] results in increased expression of BAD mRNA; [Indomethacin co-treated with juglone] results in increased expression of BAD protein; [juglone co-treated with Ascorbic Acid] results in increased expression of BAD protein
juglone results in increased expression of BAD mRNA; juglone results in increased expression of BAD protein
CTD PMID:29992683 PMID:31916655 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [Indomethacin co-treated with juglone] results in increased expression of BAX mRNA; [Indomethacin co-treated with juglone] results in increased expression of BAX protein; [juglone co-treated with Ascorbic Acid] results in increased expression of BAX protein
juglone results in increased expression of BAX mRNA; juglone results in increased expression of BAX protein
CTD PMID:29992683 PMID:31916655 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions
ISO juglone results in increased expression of BBC3 protein
[Indomethacin co-treated with juglone] results in increased expression of BBC3 protein
CTD PMID:31916655 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [Indomethacin co-treated with juglone] results in decreased expression of BCL2 mRNA
juglone results in decreased expression of BCL2 mRNA
CTD PMID:31916655 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [juglone co-treated with Ascorbic Acid] affects the expression of BID protein CTD PMID:29992683 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO [Indomethacin co-treated with juglone] results in increased expression of CASP3 mRNA; [juglone co-treated with Ascorbic Acid] results in decreased expression of CASP3 protein
juglone results in increased expression of CASP3 mRNA
CTD PMID:29992683 PMID:31916655 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO juglone results in increased activity of CASP8 protein CTD PMID:20138029 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased activity of CAT protein CTD PMID:29992683 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO juglone results in decreased expression of CCND1 mRNA; juglone results in decreased expression of CCND1 protein
[Indomethacin co-treated with juglone] results in decreased expression of CCND1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of CCND1 protein
CTD PMID:31916655 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 decreases expression
multiple interactions
ISO juglone results in decreased expression of CCND3 protein
Ascorbic Acid promotes the reaction [juglone results in decreased expression of CCND3 protein]
CTD PMID:29992683 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased expression of CDK4 protein CTD PMID:29992683 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO [Indomethacin co-treated with juglone] results in decreased expression of CTNNB1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of CTNNB1 protein
juglone results in decreased expression of CTNNB1 mRNA; juglone results in decreased expression of CTNNB1 protein
CTD PMID:31916655 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO juglone results in increased expression of CYP1A1 mRNA CTD PMID:26558468 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP
juglone results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of E2F4 protein] CTD PMID:20479004 NCBI chr19:37,252,828...37,260,239
Ensembl chr19:37,252,843...37,260,239
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGR1 protein] CTD PMID:20479004 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased activity of GSR protein CTD PMID:29992683 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions
decreases expression
ISO [Indomethacin co-treated with juglone] results in decreased expression of HES1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of HES1 protein
juglone results in decreased expression of HES1 mRNA; juglone results in decreased expression of HES1 protein
CTD PMID:31916655 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein] CTD PMID:20479004 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased phosphorylation of MAPK1 protein CTD PMID:29992683 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased phosphorylation of MAPK3 protein CTD PMID:29992683 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [juglone co-treated with Ascorbic Acid] affects the expression of MMP2 mRNA CTD PMID:29992683 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased expression of MMP9 mRNA CTD PMID:29992683 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in increased degradation of PARP1 protein CTD PMID:29992683 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions
ISO juglone results in decreased expression of PCNA protein
[Indomethacin co-treated with juglone] results in decreased expression of PCNA protein
CTD PMID:31916655 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 multiple interactions ISO juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA]; juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 protein]; juglone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PIN1 protein] CTD PMID:23754278 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO [Indomethacin co-treated with juglone] results in increased expression of PPARG mRNA; [Indomethacin co-treated with juglone] results in increased expression of PPARG protein
juglone results in increased expression of PPARG mRNA; juglone results in increased expression of PPARG protein
CTD PMID:31916655 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO [Indomethacin co-treated with juglone] results in decreased expression of PTGS2 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of PTGS2 protein; [juglone co-treated with Ascorbic Acid] results in decreased expression of PTGS2 mRNA
juglone results in decreased expression of PTGS2 mRNA; juglone results in decreased expression of PTGS2 protein
CTD PMID:29992683 PMID:31916655 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:23754278 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [juglone co-treated with Ascorbic Acid] affects the expression of TIMP1 mRNA CTD PMID:29992683 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO juglone results in increased expression of TIMP2 mRNA CTD PMID:29992683 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO [Indomethacin co-treated with juglone] results in decreased expression of TNF mRNA; [Indomethacin co-treated with juglone] results in decreased expression of TNF protein
juglone results in decreased expression of TNF mRNA; juglone results in decreased expression of TNF protein
CTD PMID:31916655 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in increased phosphorylation of TP53 protein CTD PMID:29992683 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction ISO TXNRD1 protein results in increased reduction of juglone CTD PMID:21172426 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases reduction ISO TXNRD2 protein results in increased reduction of juglone CTD PMID:21172426 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased expression of VEGFA mRNA CTD PMID:29992683 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
Lapachol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP
lapachol results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
lawsone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO lawsone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP
lawsone results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO lawsone results in decreased expression of MITF protein CTD PMID:25584612 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP lawsone results in increased activity of NQO1 protein CTD PMID:17265417 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Tyr tyrosinase multiple interactions ISO lawsone results in decreased expression of and results in decreased activity of TYR protein CTD PMID:25584612 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
naphthazarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO naphthazarin results in increased expression of CYP1A1 mRNA CTD PMID:26558468 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity EXP
ISO
naphthazarin results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
plumbagin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
plumbagin results in increased phosphorylation of AKT1 protein
plumbagin inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]
CTD PMID:20028456 PMID:32691977 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of BAD protein] CTD PMID:32691977 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
plumbagin results in increased activity of CASP3 protein
NFE2L2 protein mutant form affects the reaction [plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]; plumbagin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
CTD PMID:20028456 PMID:20576514 PMID:32691977 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO plumbagin results in increased activity of CASP8 protein
Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP8 protein]
CTD PMID:20576514 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP9 protein] CTD PMID:20576514 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein] CTD PMID:32691977 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of CCL2 protein] CTD PMID:32691977 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ctrl chymotrypsin-like multiple interactions
decreases activity
ISO Acetylcysteine inhibits the reaction [plumbagin results in decreased activity of CTRL protein] CTD PMID:31276663 NCBI chr19:37,905,864...37,907,714
Ensembl chr19:37,905,864...37,907,714
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO plumbagin results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [plumbagin results in increased expression of DDIT3 protein]; Cycloheximide inhibits the reaction [plumbagin results in increased expression of DDIT3 protein]
CTD PMID:31276663 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP
plumbagin results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Fabp3 fatty acid binding protein 3 multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of FABP3 protein] CTD PMID:32691977 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO plumbagin results in increased expression of FAS mRNA; plumbagin results in increased expression of FAS protein CTD PMID:20576514 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP plumbagin inhibits the reaction [Streptozocin results in increased activity of G6PC1 protein] CTD PMID:22960630 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO plumbagin results in increased expression of GCLM mRNA CTD PMID:20028456 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO plumbagin results in increased expression of GSTP1 mRNA CTD PMID:20028456 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hk1 hexokinase 1 multiple interactions EXP plumbagin inhibits the reaction [Streptozocin results in decreased activity of HK1 protein] CTD PMID:22960630 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]; NFE2L2 mRNA affects the reaction [plumbagin results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]
plumbagin promotes the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]
plumbagin results in increased expression of HMOX1 mRNA; plumbagin results in increased expression of HMOX1 protein
CTD PMID:20028456 PMID:32691977 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO plumbagin results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]; Cycloheximide inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]
CTD PMID:31276663 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
plumbagin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
plumbagin inhibits the reaction [Doxorubicin results in increased expression of IFNG protein]
CTD PMID:23942037 PMID:32691977 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO plumbagin results in increased phosphorylation of MAPK1 protein CTD PMID:20028456 PMID:20576514 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO plumbagin results in increased phosphorylation of MAPK3 protein CTD PMID:20028456 PMID:20576514 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
affects response to substance
ISO
EXP
NFE2L2 mRNA affects the reaction [plumbagin results in decreased susceptibility to tert-Butylhydroperoxide]; NFE2L2 mRNA affects the reaction [plumbagin results in increased expression of HMOX1 mRNA]
plumbagin affects the localization of NFE2L2 protein
NFE2L2 protein mutant form affects the reaction [plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]
NFE2L2 mRNA affects the susceptibility to plumbagin
CTD PMID:20028456 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein] CTD PMID:32691977 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO plumbagin results in increased expression of NQO1 mRNA; plumbagin results in increased expression of NQO1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [plumbagin results in increased expression of NQO1 protein]; wortmannin inhibits the reaction [plumbagin results in increased expression of NQO1 protein]
CTD PMID:20028456 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Per2 period circadian regulator 2 decreases response to substance ISO PER2 protein mutant form results in decreased susceptibility to plumbagin CTD PMID:25628599 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in decreased phosphorylation of PTEN protein] CTD PMID:32691977 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions ISO plumbagin binds to and results in decreased activity of PTPN2 protein CTD PMID:31248982 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Pygb glycogen phosphorylase B multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of PYGB protein] CTD PMID:32691977 NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP plumbagin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; plumbagin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:22960630 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO plumbagin results in increased expression of SQSTM1 protein CTD PMID:31276663 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] CTD PMID:32691977 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:32691977 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO plumbagin results in increased expression of TXNRD1 mRNA CTD PMID:20028456 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of plumbagin CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of plumbagin CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of plumbagin CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
Shikonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO shikonin results in decreased expression of ACTA2 mRNA CTD PMID:25591861 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO shikonin results in decreased phosphorylation of AKT1 protein
shikonin promotes the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]
CTD PMID:24463199 PMID:28684144 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ATF3 mRNA] CTD PMID:25451590 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO shikonin results in decreased expression of BCL2 protein CTD PMID:25591861 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases cleavage ISO shikonin results in increased cleavage of CASP3 protein CTD PMID:25591861 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL1 mRNA] CTD PMID:25451590 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL4 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of CCL4 mRNA] CTD PMID:25451590 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL7 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of CCL7 mRNA] CTD PMID:25451590 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP
ISO
shikonin results in decreased expression of CCND1 protein CTD PMID:16061028 PMID:28684144 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases expression EXP shikonin results in decreased expression of CCNE1 protein CTD PMID:16061028 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP
ISO
shikonin results in increased expression of CDKN1A protein CTD PMID:16061028 PMID:28684144 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO shikonin results in decreased expression of COL1A1 mRNA CTD PMID:25591861 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO shikonin results in decreased expression of COL3A1 mRNA CTD PMID:25591861 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CSF1 mRNA] CTD PMID:25451590 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of AXUD1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of AXUD1 mRNA] CTD PMID:25451590 NCBI chr 8:128,659,883...128,673,339
Ensembl chr 8:128,659,868...128,672,284
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP
ISO
shikonin results in decreased activity of CYP1A2 protein CTD PMID:28941798 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP shikonin results in decreased activity of CYP2B1 protein CTD PMID:28941798 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO shikonin results in decreased activity of CYP2B6 protein CTD PMID:28941798 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP
ISO
shikonin results in decreased activity of CYP2C11 protein
shikonin results in decreased activity of CYP2C9 protein
CTD PMID:28941798 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 decreases activity EXP shikonin results in decreased activity of CYP2D1 protein CTD PMID:28941798 NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO shikonin results in decreased activity of CYP2D6 protein CTD PMID:28941798 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP
ISO
shikonin results in decreased activity of CYP2E1 protein CTD PMID:28941798 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
EXP shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam]
shikonin results in decreased activity of CYP3A2 protein
CTD PMID:28941798 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO shikonin results in decreased activity of CYP3A4 protein CTD PMID:28941798 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of DUSP1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of DUSP1 mRNA] CTD PMID:25451590 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of DUSP6 mRNA] CTD PMID:25451590 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Egr2 early growth response 2 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of EGR2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of EGR2 mRNA] CTD PMID:25451590 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Egr3 early growth response 3 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of EGR3 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of EGR3 mRNA] CTD PMID:25451590 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO shikonin affects the reaction [Oxygen deficiency affects the phosphorylation of EIF4EBP1 protein] CTD PMID:28684144 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOS mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of FOS mRNA] CTD PMID:25451590 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOSB mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of FOSB mRNA] CTD PMID:25451590 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO shikonin results in decreased expression of HIF1A protein
shikonin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:28684144 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Il13 interleukin 13 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of IL13 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA] CTD PMID:25451590 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO shikonin results in decreased expression of ITGB1 mRNA; shikonin results in decreased expression of ITGB1 protein CTD PMID:23562787 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of JUN mRNA] CTD PMID:25451590 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of MAP3K8 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of MAP3K8 mRNA] CTD PMID:25451590 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK1 protein]
shikonin results in increased phosphorylation of MAPK1 protein
CTD PMID:23562787 PMID:24463199 PMID:25591861 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO shikonin results in decreased phosphorylation of MAPK3 protein
shikonin results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK3 protein]
CTD PMID:23562787 PMID:24463199 PMID:25591861 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of MT2 mRNA] CTD PMID:25451590 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO shikonin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein] CTD PMID:28684144 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfkbid NFKB inhibitor delta multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NFKBID mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NFKBID mRNA] CTD PMID:25451590 NCBI chr 1:88,883,816...88,892,543
Ensembl chr 1:88,885,937...88,892,615
JBrowse link
G Nfkbiz NFKB inhibitor zeta multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NFKBIZ mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NFKBIZ mRNA] CTD PMID:25451590 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A1 mRNA] CTD PMID:25451590 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A2 mRNA] CTD PMID:25451590 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A3 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A3 mRNA] CTD PMID:25451590 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of OLR1 mRNA] CTD PMID:25451590 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [shikonin results in increased cleavage of PARP1 protein] CTD PMID:24463199 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP shikonin results in decreased expression of PCNA protein CTD PMID:16061028 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Plk3 polo-like kinase 3 multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of PLK3 mRNA] CTD PMID:25451590 NCBI chr 5:135,997,725...136,002,900
Ensembl chr 5:135,997,725...136,002,900
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of PPP1R15A mRNA] CTD PMID:25451590 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of PTGS2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of PTGS2 mRNA] CTD PMID:25451590 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO shikonin promotes the reaction [RIPK1 protein binds to RIPK3 protein] CTD PMID:23261677 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO shikonin promotes the reaction [RIPK1 protein binds to RIPK3 protein] CTD PMID:23261677 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO shikonin promotes the reaction [Oxygen deficiency results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:28684144 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of SERPINE1 mRNA] CTD PMID:25451590 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Tagap T-cell activation RhoGTPase activating protein multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of TAGAP mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of TAGAP mRNA] CTD PMID:25451590 NCBI chr 1:47,493,990...47,503,492
Ensembl chr 1:47,493,994...47,502,952
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of TNF mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of TNF mRNA] CTD PMID:25451590 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO shikonin results in increased expression of TP53 protein CTD PMID:28684144 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO
EXP
shikonin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol] CTD PMID:31128210 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO shikonin inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Chenodeoxycholic Acid] CTD PMID:31128210 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO shikonin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol] CTD PMID:31128210 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO shikonin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine] CTD PMID:31128210 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ZFP36 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of ZFP36 mRNA] CTD PMID:25451590 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ZFP36L1 mRNA] CTD PMID:25451590 NCBI chr 6:103,308,032...103,313,074
Ensembl chr 6:103,308,045...103,313,074
JBrowse link
ubiquinone-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO [NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q1; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q1 CTD PMID:20399199 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
ubiquinone-9 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 decreases abundance ISO KCNJ6 gene mutant form results in decreased abundance of ubiquinone 9 CTD PMID:15256069 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
ubiquinones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions EXP Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:20584200 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO ubiquinones decrease 4-hydroxynonenal-Aldh2 protein adduct formation; decrease acylation, nitrosylation, S-nitrosylation, and nitration of Aldh2 protein in mouse liver RGD PMID:29156373 RGD:15036805 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Ubiquinone inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA] CTD PMID:12880480 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases activity EXP Ubiquinone results in increased activity of CAT protein CTD PMID:20034476 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Coq8a coenzyme Q8A increases chemical synthesis ISO COQ8A protein results in increased chemical synthesis of Ubiquinone CTD PMID:18319072 NCBI chr13:98,451,629...98,480,438
Ensembl chr13:98,451,637...98,480,419
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
increases metabolic processing
ISO
EXP
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; A 771726 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
DHODH protein results in increased metabolism of Ubiquinone
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; A 771726 inhibits the reaction [DHODH protein results in increased metabolism of Ubiquinone]; A 771726 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
CTD PMID:9802339 PMID:11248707 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL1B protein] CTD PMID:17516992 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL6 protein] CTD PMID:17516992 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 mRNA]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 protein]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3] CTD PMID:20020783 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Niacin co-treated with Ubiquinone co-treated with Riboflavin] results in increased expression of PARP1 protein CTD PMID:18377693 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO PPARA protein affects the reaction [Diethylhexyl Phthalate affects the abundance of Ubiquinone] CTD PMID:10731415 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of TNF protein] CTD PMID:17516992 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases reduction
decreases oxidation
ISO XRCC1 gene mutant form results in decreased reduction of Ubiquinone
XRCC1 results in decreased oxidation of Ubiquinone
CTD PMID:30998386 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19783
    chemical entity 19783
      molecular entity 19782
        polyatomic entity 19700
          heteroatomic molecular entity 19632
            hydroxides 19085
              organic hydroxy compound 18661
                hydroxyquinone 188
                  horminone + 0
                  hydroxybenzoquinone + 92
                  hydroxynaphthoquinone + 126
Path 2
Term Annotations click to browse term
  CHEBI ontology 19783
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18606
                              organic divalent group 18597
                                organodiyl group 18597
                                  carbonyl group 18510
                                    carbonyl compound 18510
                                      ketone 16828
                                        cyclic ketone 15242
                                          quinone 8387
                                            hydroxyquinone 188
                                              horminone + 0
                                              hydroxybenzoquinone + 92
                                              hydroxynaphthoquinone + 126
paths to the root