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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sodium propionate
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Accession:CHEBI:132106 term browser browse the term
Definition:An organic sodium salt comprising equal numbers of sodium and propionate ions.
Synonyms:exact_synonym: sodium propanoate
 related_synonym: E281;   Formula=C3H5NaO2;   InChI=1S/C3H6O2.Na/c1-2-3(4)5;/h2H2,1H3,(H,4,5);/q;+1/p-1;   InChIKey=JXKPEJDQGNYQSM-UHFFFAOYSA-M;   Natriumpropionat;   Propanoic acid, sodium salt;   Propionic acid sodium salt;   SMILES=[Na+].C(=O)([O-])CC;   Sodium propionate anhydrous
 xref: CAS:137-40-6;   KEGG:D08440
 xref_mesh: MESH:C514135
 xref: PMID:26141376;   PMID:27173555;   Reaxys:3566934;   Wikipedia:Sodium_propionate



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sodium propionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of BAX mRNA] CTD PMID:35639301 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Casp3 caspase 3 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of and results in increased cleavage of CASP3 mRNA] CTD PMID:35639301 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp8 caspase 8 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of CASP8 mRNA] CTD PMID:35639301 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Cldn1 claudin 1 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in decreased expression of CLDN1 protein] CTD PMID:35639301 NCBI chr11:87,926,376...87,941,533 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO sodium propionate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:31621310 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO sodium propionate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; sodium propionate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] CTD PMID:31621310 NCBI chr 6:21,093,927...21,103,091 JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of HDAC2 mRNA]; sodium propionate inhibits the reaction [Ethanol results in increased expression of HDAC2 protein] CTD PMID:35639301 NCBI chr20:42,101,815...42,126,486 JBrowse link
G Hdac6 histone deacetylase 6 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of HDAC6 mRNA] CTD PMID:35639301 NCBI chr  X:14,550,645...14,572,445 JBrowse link
G Ifng interferon gamma multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IFNG mRNA] CTD PMID:37269894 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IKBKB mRNA]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IKBKB protein] CTD PMID:37269894 NCBI chr16:76,021,968...76,075,717 JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IL6 mRNA] CTD PMID:37269894 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
EXP [sodium propionate co-treated with Cadmium] results in increased expression of MT1A mRNA; [sodium propionate co-treated with Dexamethasone] results in increased expression of MT1A mRNA
sodium propionate results in increased expression of MT1A mRNA
CTD PMID:1597404 NCBI chr19:10,831,959...10,832,975 JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of MYD88 mRNA] CTD PMID:37269894 NCBI chr 8:127,952,161...127,956,230 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in decreased expression of NFKBIA protein] CTD PMID:37269894 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA] CTD PMID:35639301 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of NOX1 mRNA]; sodium propionate inhibits the reaction [TNF protein affects the acetylation of NOX1 promoter] CTD PMID:35639301 NCBI chr  X:97,279,058...97,332,291 JBrowse link
G Ocln occludin multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in decreased expression of OCLN protein] CTD PMID:35639301 NCBI chr 2:33,391,303...33,442,207 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of and results in increased phosphorylation of RELA protein]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of RELA mRNA] CTD PMID:37269894 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TGFB1 mRNA] CTD PMID:37269894 NCBI chr 1:90,324,312...90,340,627 JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in decreased expression of TJP1 protein] CTD PMID:35639301 NCBI chr 1:128,260,330...128,505,018 JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR2 mRNA]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR2 protein] CTD PMID:37269894 NCBI chr 2:171,499,189...171,504,831 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR4 mRNA]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR4 protein] CTD PMID:37269894 NCBI chr 5:85,161,247...85,174,882 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TNF mRNA]; sodium propionate inhibits the reaction [TNF protein affects the acetylation of NOX1 promoter] CTD PMID:35639301 PMID:37269894 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO sodium propionate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA] CTD PMID:31621310 NCBI chr 9:96,249,143...96,256,264 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      application 19715
        food additive 16861
          food preservative 12662
            sodium propionate 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic ion 11452
                              organic anion 6854
                                carboxylic acid anion 2501
                                  monocarboxylic acid anion 1606
                                    fatty acid anion 138
                                      short-chain fatty acid anion 138
                                        fatty acid anion 3:0 26
                                          propionate 26
                                            sodium propionate 24
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