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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:norverapamil
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Accession:CHEBI:132050 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-norverapamil. The major active metabolite of verapamil.
Synonyms:exact_synonym: rac-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile
 related_synonym: (RS)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile;   (RS)-norverapamil;   5-((3,4-Dimethoxyphenethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile;   Formula=C26H36N2O4;   alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)amino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile;   desmethylverapamil;   rac-norverapamil
 xref: CAS:67018-85-3;   Chemspider:94724;   HMDB:HMDB0060540
 xref_mesh: MESH:C016904
 xref: PMID:10336579;   PMID:10613599;   PMID:10701911;   PMID:11377051;   PMID:11456122;   PMID:11777750;   PMID:11996822;   PMID:12016885;   PMID:15563760;   PMID:15918524;   PMID:16013069;   PMID:16892180;   PMID:17981422;   PMID:18193210;   PMID:18806964;   PMID:19746412;   PMID:19898809;   PMID:20166433;   PMID:20604832;   PMID:21135265;   PMID:22300394;   PMID:22677487;   PMID:23757929;   PMID:23916407;   PMID:24044638;   PMID:24532601;   PMID:25237334;   PMID:25571292;   PMID:25650380;   PMID:26265240;   PMID:26643325;   PMID:27457673;   PMID:27750166;   PMID:8554934;   PMID:9572542;   PMID:9613945;   Reaxys:5458977;   Wikipedia:Norverapamil



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norverapamil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity ISO norverapamil results in decreased activity of CYP3A5 protein CTD PMID:15689501 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        xenobiotic 18664
          norverapamil 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  azane 17503
                                    ammonia 17502
                                      organic amino compound 17502
                                        secondary amino compound 6679
                                          2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl]amino\}-2-(propan-2-yl)pentanenitrile 1
                                            (R)-norverapamil 1
                                              norverapamil 1
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