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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tyrphostin B42
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Accession:CHEBI:131968 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine.
Synonyms:exact_synonym: (2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
 related_synonym: AG 490;   AG490;   Formula=C17H14N2O3;   InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+;   InChIKey=TUCIOBMMDDOEMM-RIYZIHGNSA-N;   SMILES=C=1(C=CC(=CC1O)/C=C(/C(NCC=2C=CC=CC2)=O)\\C#N)O;   tyrphostin AG-490
 xref: CAS:133550-30-8;   LINCS:LSM-42880;   PMID:10929036;   PMID:22363408;   PMID:26190257;   PMID:26438799;   PMID:26487394;   PMID:26750536;   PMID:26919242;   PMID:27011172;   PMID:27044832;   PMID:27101310;   PMID:27107220;   PMID:27274711;   Reaxys:4323263


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tyrphostin B42 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO tyrphostin B42 alone or co-treated with Nimesulide decreases expression of BIRC5 protein in esophagus squamous epithelium RGD PMID:25724470 RGD:127285656 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases cleavage of CASP3 protein in stomach] RGD PMID:32106377 RGD:127284886 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid decreases cleavage of CASP9 protein in stomach] RGD PMID:32106377 RGD:127284886 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Jak2 Janus kinase 2 decreases expression
multiple interactions		 EXP
ISO		 Turphostin B42 decreased expression of Jak2 mRNA in myofibroblasts
tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of JAK2 protein in stomach]
tyrphostin B42 decreases expression and phosphorylation of JAK2 protein in colonic epithelium
tyrphostin B42 inhibits the reaction [selumetinib increases phosphorylation of JAK2 protein in colonic epithelium]
tyrphostin B42 inhibits the reaction [cisplatin increases expression of Jak2 mRNA in kidney]		 RGD PMID:26385087 PMID:32106377 PMID:22050790 PMID:30706361 PMID:31250048 RGD:18337263, RGD:127284886, RGD:127285665, RGD:127285668, RGD:149735351 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Tyrphostin B42 alone or co-treated with Nimesulide decreases expression of MT-CO2 protein in esophagus squamous epithelium RGD PMID:25724470 RGD:127285656 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of STAT3 protein in stomach] RGD PMID:32106377 RGD:127284886 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      chemical role 19497
        antioxidant 16054
          tyrphostin B42 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    p-block element atom 19845
                      carbon group element atom 19792
                        carbon atom 19787
                          organic molecular entity 19787
                            organic group 18957
                              organic divalent group 18938
                                organodiyl group 18938
                                  carbonyl group 18890
                                    carbonyl compound 18890
                                      carboxylic acid 18611
                                        carboacyl group 17702
                                          univalent carboacyl group 17702
                                            carbamoyl group 17547
                                              carboxamide 17547
                                                alpha,beta-unsaturated carboxylic acid amide 7102
                                                  enamide 7102
                                                    tyrphostin B42 6
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