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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tyrphostin B42
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Accession:CHEBI:131968 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine.
Synonyms:exact_synonym: (2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
 related_synonym: AG 490;   AG490;   Formula=C17H14N2O3;   InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+;   InChIKey=TUCIOBMMDDOEMM-RIYZIHGNSA-N;   SMILES=C=1(C=CC(=CC1O)/C=C(/C(NCC=2C=CC=CC2)=O)\\C#N)O;   tyrphostin AG-490
 xref: CAS:133550-30-8;   LINCS:LSM-42880;   PMID:10929036;   PMID:22363408;   PMID:26190257;   PMID:26438799;   PMID:26487394;   PMID:26750536;   PMID:26919242;   PMID:27011172;   PMID:27044832;   PMID:27101310;   PMID:27107220;   PMID:27274711;   Reaxys:4323263



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tyrphostin B42 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO tyrphostin B42 alone or co-treated with Nimesulide decreases expression of BIRC5 protein in esophagus squamous epithelium RGD PMID:25724470 RGD:127285656 NCBI chr10:103,567,369...103,580,069 JBrowse link
G Casp3 caspase 3 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases cleavage of CASP3 protein in stomach] RGD PMID:32106377 RGD:127284886 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp9 caspase 9 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid decreases cleavage of CASP9 protein in stomach] RGD PMID:32106377 RGD:127284886
G Jak2 Janus kinase 2 decreases expression
multiple interactions
EXP
ISO
Turphostin B42 decreased expression of Jak2 mRNA in myofibroblasts
tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of JAK2 protein in stomach]
tyrphostin B42 decreases expression and phosphorylation of JAK2 protein in colonic epithelium
tyrphostin B42 inhibits the reaction [selumetinib increases phosphorylation of JAK2 protein in colonic epithelium]
tyrphostin B42 inhibits the reaction [cisplatin increases expression of Jak2 mRNA in kidney]
RGD PMID:26385087 PMID:32106377 PMID:22050790 PMID:30706361 PMID:31250048 RGD:18337263, RGD:127284886, RGD:127285665, RGD:127285668, RGD:149735351 NCBI chr 1:236,408,905...236,468,769 JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Tyrphostin B42 alone or co-treated with Nimesulide decreases expression of MT-CO2 protein in esophagus squamous epithelium RGD PMID:25724470 RGD:127285656
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of STAT3 protein in stomach] RGD PMID:32106377 RGD:127284886 NCBI chr10:86,311,528...86,363,513 JBrowse link

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  CHEBI ontology 19898
    role 19869
      chemical role 19500
        antioxidant 16189
          tyrphostin B42 6
Path 2
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      carboacyl group 17726
                                        univalent carboacyl group 17726
                                          carbamoyl group 17570
                                            carboxamide 17570
                                              alpha,beta-unsaturated carboxylic acid amide 7125
                                                enamide 7125
                                                  tyrphostin B42 6
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