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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tyrphostin B42
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Accession:CHEBI:131968 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine.
Synonyms:exact_synonym: (2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
 related_synonym: AG 490;   AG490;   Formula=C17H14N2O3;   InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+;   InChIKey=TUCIOBMMDDOEMM-RIYZIHGNSA-N;   SMILES=C=1(C=CC(=CC1O)/C=C(/C(NCC=2C=CC=CC2)=O)\\C#N)O
 xref: PMID:10929036;   PMID:26190257;   PMID:26438799;   PMID:26487394;   PMID:26750536;   PMID:26919242;   PMID:27011172;   PMID:27044832;   PMID:27101310;   PMID:27107220;   PMID:27274711;   Reaxys:4323263

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tyrphostin B42 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak2 Janus kinase 2 decreases expression EXP Turphostin B42 decreased expression of Jak2 mRNA in myofibroblasts RGD PMID:26385087 RGD:18337263 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        antioxidant 14211
          tyrphostin B42 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                alpha,beta-unsaturated carboxylic acid amide 4754
                                                  enamide 4754
                                                    tyrphostin B42 1
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