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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitor
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Accession:CHEBI:131961 term browser browse the term
Definition:An EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor that interferes with the action of tryptophan 2,3-dioxygenase (EC 1.13.11.11).
Synonyms:related_synonym: EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitors;   EC 1.13.11.11 inhibitor;   EC 1.13.11.11 inhibitors;   L-tryptophan 2,3-dioxygenase inhibitor;   L-tryptophan 2,3-dioxygenase inhibitors;   L-tryptophan pyrrolase inhibitor;   L-tryptophan pyrrolase inhibitors;   L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) inhibitor;   L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) inhibitors;   L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening) inhibitor;   L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening) inhibitors;   TDO inhibitor;   TDO inhibitors;   indolamine 2,3-dioxygenase inhibitor;   indolamine 2,3-dioxygenase inhibitors;   indoleamine 2,3-dioxygenase inhibitor;   indoleamine 2,3-dioxygenase inhibitors;   tryptamin 2,3-dioxygenase inhibitor;   tryptamin 2,3-dioxygenase inhibitors;   tryptamine 2,3-dioxygenase inhibitor;   tryptamine 2,3-dioxygenase inhibitors;   tryptophan 2,3-dioxygenase inhibitor;   tryptophan 2,3-dioxygenase inhibitors;   tryptophan oxygenase inhibitor;   tryptophan oxygenase inhibitors;   tryptophan peroxidase inhibitor;   tryptophan peroxidase inhibitors;   tryptophan pyrrolase inhibitor;   tryptophan pyrrolase inhibitors;   tryptophanase inhibitor;   tryptophanase inhibitors
 xref: Wikipedia:Tryptophan_2\,3-dioxygenase



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680C91 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO TDO inhibitor LM10 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CYP1A1 mRNA] CTD PMID:24930766 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G H2ax H2A.X variant histone decreases expression ISO TDO inhibitor LM10 results in decreased expression of H2AX protein modified form CTD PMID:26651356 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Polk DNA polymerase kappa decreases expression ISO TDO inhibitor LM10 results in decreased expression of POLK protein CTD PMID:26651356 NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity ISO TDO inhibitor LM10 results in decreased activity of TDO2 protein CTD PMID:21726069 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19759
      biological role 19759
        biochemical role 19379
          enzyme inhibitor 18390
            EC 1.* (oxidoreductase) inhibitor 16719
              EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor 5062
                EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor 5062
                  EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitor 4
                    680C91 4
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