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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dicarboxylic acids and O-substituted derivatives
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Accession:CHEBI:131927 term browser browse the term
Definition:A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens.
Synonyms:related_synonym: dicarboxylic acids and derivatives



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aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis
EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP benazepril results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376
JBrowse link
bilirubin IXalpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Bilirubin inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of CASP3 protein] CTD PMID:16371440 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G GH1 growth hormone 1 multiple interactions EXP GH1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Bilirubin] CTD PMID:9185964 NCBI chr12:15,064,965...15,066,698
Ensembl chr12:15,064,909...15,066,696
JBrowse link
cinaciguat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein] CTD PMID:19466990 NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,232...44,518,135
JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein] CTD PMID:19466990 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,704
JBrowse link
diethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRDX2 peroxiredoxin 2 decreases activity EXP diethyl maleate results in decreased activity of PRDX2 protein CTD PMID:19208552 NCBI chr 2:66,207,829...66,211,474
Ensembl chr 2:66,207,796...66,213,567
JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Enalapril affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
enalaprilat dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases activity EXP Enalaprilat results in decreased activity of AGT protein modified form CTD PMID:7890486 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G KNG1 kininogen 1 increases activity EXP Enalaprilat results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376
JBrowse link
maleic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO2 aconitase 2 multiple interactions
decreases activity
EXP Curcumin inhibits the reaction [maleic acid results in decreased activity of ACO2 protein] CTD PMID:25119790 NCBI chr 5:7,014,383...7,071,023
Ensembl chr 5:7,002,124...7,070,999
JBrowse link
sarpogrelate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS protein] CTD PMID:11426759 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN protein] CTD PMID:11426759 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK1 protein] CTD PMID:11426759 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK3 protein] CTD PMID:11426759 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 925
    chemical entity 925
      group 892
        inorganic group 718
          oxo group 406
            organic oxo compound 406
              carbonyl compound 406
                dicarboxylic acids and O-substituted derivatives 13
                  1,12-di-L-ascorbyl dodecanedioate 0
                  3,4-di-O-acetyl-6-deoxy-L-glucal 0
                  Dibutyl succinate 0
                  Methyl oxalate 0
                  Rangiformic acid 0
                  allyl octadecyl oxalate 0
                  bis(2-ethylhexyl) adipate 0
                  dicarboxylic acid + 13
                  dicarboxylic acid monoester + 6
                  diethyl 2-hydroxypentanedioate 0
                  ethyl 2-phenylethyl dimethylmalonate 0
                  ethyl 3-methylbutyl butanedioate 0
                  isobutyl 2-phenylethyl 2,6-pyridinedicarboxylate 0
                  methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate + 0
                  nemadipine-A 0
                  nimodipine 0
                  nitrendipine 0
                  phthalate ester + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 925
    subatomic particle 910
      composite particle 910
        hadron 910
          baryon 910
            nucleon 910
              atomic nucleus 910
                atom 910
                  main group element atom 873
                    p-block element atom 870
                      carbon group element atom 846
                        carbon atom 845
                          organic molecular entity 845
                            organic group 409
                              organic divalent group 407
                                organodiyl group 407
                                  carbonyl group 406
                                    carbonyl compound 406
                                      dicarboxylic acids and O-substituted derivatives 13
                                        1,12-di-L-ascorbyl dodecanedioate 0
                                        3,4-di-O-acetyl-6-deoxy-L-glucal 0
                                        Dibutyl succinate 0
                                        Methyl oxalate 0
                                        Rangiformic acid 0
                                        allyl octadecyl oxalate 0
                                        bis(2-ethylhexyl) adipate 0
                                        dicarboxylic acid + 13
                                        dicarboxylic acid monoester + 6
                                        diethyl 2-hydroxypentanedioate 0
                                        ethyl 2-phenylethyl dimethylmalonate 0
                                        ethyl 3-methylbutyl butanedioate 0
                                        isobutyl 2-phenylethyl 2,6-pyridinedicarboxylate 0
                                        methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate + 0
                                        nemadipine-A 0
                                        nimodipine 0
                                        nitrendipine 0
                                        phthalate ester + 0
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