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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:salubrinal
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Accession:CHEBI:131923 term browser browse the term
Definition:A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).
Synonyms:exact_synonym: (2E)-3-phenyl-N-{2,2,2-trichloro-1-[(quinolin-8-ylcarbamothioyl)amino]ethyl}acrylamide
 related_synonym: (E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide;   Formula=C21H17Cl3N4OS;   InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+;   InChIKey=LCOIAYJMPKXARU-VAWYXSNFSA-N;   SMILES=C=1C=2C(C(=CC1)NC(NC(NC(/C=C/C=3C=CC=CC3)=O)C(Cl)(Cl)Cl)=S)=NC=CC2
 xref: CAS:405060-95-9
 xref_mesh: MESH:C496827
 xref: PMID:15705855;   PMID:22610062;   PMID:23178987;   PMID:23473976;   PMID:23603983;   PMID:23816340;   PMID:23824972;   PMID:24418467;   PMID:24728926;   PMID:25030410;   PMID:25157407;   PMID:25230871;   PMID:25435425;   PMID:25582550;   PMID:25619567;   PMID:25816071;   PMID:25882497;   PMID:25977571;   PMID:26021511;   PMID:26193263;   PMID:26328492;   PMID:26505387;   PMID:26743901;   PMID:26889171;   PMID:27123756;   PMID:27131989;   Patent:EP2589593;   Reaxys:13925629;   Wikipedia:Salubrinal


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salubrinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of FN1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; salubrinal inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein] CTD PMID:25398788 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP salubrinal inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] CTD PMID:25398788 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO salubrinal results in increased expression of ATF3 mRNA CTD PMID:23690448 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO
EXP		 [salubrinal co-treated with EPO protein] results in decreased expression of ATF4 protein; salubrinal inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATF4 protein]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of ATF4 protein]]; salubrinal promotes the reaction [T-2 Toxin results in increased expression of ATF4 protein]
salubrinal results in increased expression of ATF4 protein
salubrinal promotes the reaction [Cisplatin results in increased expression of ATF4 protein]
salubrinal promotes the reaction [Thapsigargin results in increased expression of ATF4 protein]; salubrinal promotes the reaction [Tunicamycin results in increased expression of ATF4 protein]		 CTD PMID:21616140 PMID:21809093 PMID:23690448 PMID:25950987 PMID:28844859 More... NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO salubrinal results in increased expression of ATF6 mRNA CTD PMID:23958496 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein]]; salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein]
salubrinal inhibits the reaction [cadmium acetate results in increased expression of BAX protein]		 CTD PMID:21616140 PMID:30605698 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP		 salubrinal inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]]; salubrinal promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]
salubrinal inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]		 CTD PMID:20686688 PMID:21616140 PMID:30605698 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of BECN1 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased expression of BECN1 protein] CTD PMID:20929985 PMID:33127495 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of BNIP3 protein] CTD PMID:33127495 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Calr calreticulin multiple interactions ISO [salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein CTD PMID:17187072 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP		 Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]]; salubrinal inhibits the reaction [decamethrin results in increased expression of CASP12 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of CASP12 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of CASP12 mRNA]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]
salubrinal inhibits the reaction [arsenite results in increased activity of CASP12 protein]; salubrinal inhibits the reaction [Rotenone results in increased cleavage of CASP12 protein]
salubrinal inhibits the reaction [T-2 Toxin results in increased expression of CASP12 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of CASP12 protein]		 CTD PMID:18226606 PMID:21616140 PMID:25428620 PMID:26446018 PMID:31841155 More... NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 salubrinal inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; salubrinal inhibits the reaction [MAP3K5 protein results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Paraquat results in increased activity of CASP3 protein]
salubrinal inhibits the reaction [decamethrin results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [decamethrin results in increased cleavage of and results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of CASP3 mRNA]; salubrinal promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]
salubrinal inhibits the reaction [Rotenone results in increased expression of CASP3 mRNA]; salubrinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased cleavage of CASP3 protein]		 CTD PMID:19735704 PMID:20929985 PMID:21616140 PMID:21809093 PMID:24932542 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein]]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein] CTD PMID:21616140 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO salubrinal inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA] CTD PMID:23958496 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO salubrinal inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] CTD PMID:23958496 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO salubrinal inhibits the reaction [Cyclosporine results in decreased expression of CDH1 protein] CTD PMID:22155090 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA] CTD PMID:23690541 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA] CTD PMID:23690541 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO salubrinal inhibits the reaction [MAP3K5 protein affects the localization of CYCS protein]; salubrinal inhibits the reaction [Paraquat affects the localization of CYCS protein] CTD PMID:20929985 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
decreases expression		 ISO
EXP		 EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]; salubrinal inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 protein]
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of DDIT3 protein]]; salubrinal inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Cisplatin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Cyclosporine results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Tacrolimus results in increased expression of DDIT3 protein]
salubrinal results in increased expression of DDIT3 mRNA
salubrinal results in decreased expression of DDIT3 protein
salubrinal inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Tunicamycin results in increased expression of DDIT3 protein]		 CTD PMID:18305250 PMID:19735704 PMID:20686688 PMID:21616140 PMID:21809093 More... NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 multiple interactions ISO salubrinal inhibits the reaction [Paraquat results in increased expression of EDEM1 protein] CTD PMID:19735704 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions
increases phosphorylation
affects phosphorylation
increases expression		 ISO
EXP		 salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein]; salubrinal inhibits the reaction [EIF2A protein results in decreased susceptibility to nonivamide]
salubrinal results in increased phosphorylation of EIF2A protein
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased phosphorylation of EIF2A protein]]; salubrinal promotes the reaction [Cisplatin results in increased phosphorylation of EIF2A protein]
salubrinal affects the phosphorylation of EIF2A protein
salubrinal results in increased expression of EIF2A protein modified form		 CTD PMID:17332266 PMID:17418795 PMID:18305250 PMID:18684481 PMID:20071420 More... NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression
multiple interactions
increases phosphorylation		 ISO
EXP		 salubrinal results in increased expression of EIF2S1 protein modified form
[salubrinal co-treated with EPO protein] results in increased phosphorylation of EIF2S1 protein; [salubrinal results in decreased activity of EIF2S1 protein] which results in decreased susceptibility to decamethrin; EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]; EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased phosphorylation of EIF2S1 protein]]; salubrinal promotes the reaction [Cadmium Chloride results in increased phosphorylation of EIF2S1 protein]; salubrinal promotes the reaction [Paraquat results in increased expression of EIF2S1 protein modified form]; salubrinal results in increased phosphorylation of and results in decreased activity of EIF2S1 protein
salubrinal results in increased phosphorylation of EIF2S1 protein
[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK1 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK3 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK8 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK9 protein; salubrinal inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form]; salubrinal inhibits the reaction [Rotenone results in decreased phosphorylation of EIF2S1 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of EIF2S1 mRNA]; salubrinal inhibits the reaction [Tunicamycin results in increased expression of EIF2S1 mRNA]; salubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of EIF2S1 protein]
salubrinal inhibits the reaction [Rotenone results in decreased phosphorylation of EIF2S1 protein]; salubrinal promotes the reaction [T-2 Toxin results in increased phosphorylation of EIF2S1 protein]		 CTD PMID:21147958 PMID:21555338 PMID:21809093 PMID:23690448 PMID:24932542 More... NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Epo erythropoietin multiple interactions ISO [salubrinal co-treated with EPO protein] results in decreased expression of ATF4 protein; [salubrinal co-treated with EPO protein] results in increased phosphorylation of EIF2S1 protein CTD PMID:23690448 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP salubrinal inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:25398788 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of FOXO3 protein] CTD PMID:33127495 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP salubrinal inhibits the reaction [Rotenone results in decreased activity of GSR protein] CTD PMID:26446018 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO salubrinal promotes the reaction [Cisplatin results in increased expression of HAVCR1 mRNA] CTD PMID:21616140 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP salubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]; salubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF protein]; salubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]; salubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF protein] CTD PMID:28844859 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO
EXP		 EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein]
salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; salubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HSPA5 protein]
salubrinal results in increased expression of HSPA5 protein
salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein]		 CTD PMID:19735704 PMID:24932542 PMID:25428620 PMID:26446018 PMID:28844859 More... NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 affects response to substance
multiple interactions		 ISO salubrinal affects the susceptibility to MAP3K5 protein
salubrinal affects the susceptibility to [Paraquat co-treated with MAP3K5 protein]; salubrinal inhibits the reaction [MAP3K5 protein affects the localization of CYCS protein]; salubrinal inhibits the reaction [MAP3K5 protein results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Paraquat results in increased phosphorylation of and results in increased activity of MAP3K5 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased expression of BECN1 protein]		 CTD PMID:19735704 PMID:20929985 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK1 protein]
[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK1 protein		 CTD PMID:21147958 PMID:22155090 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein] CTD PMID:21809093 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK3 protein]
[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK3 protein		 CTD PMID:21147958 PMID:22155090 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO		 [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK8 protein
salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein]; salubrinal inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]		 CTD PMID:20686688 PMID:21147958 PMID:21809093 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO
EXP		 salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein]
[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK9 protein		 CTD PMID:20686688 PMID:21147958 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO [salubrinal co-treated with T-2 Toxin] results in increased expression of MMP13 mRNA; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein] CTD PMID:34673134 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Myh3 myosin heavy chain 3 decreases expression ISO salubrinal results in decreased expression of MYH3 protein CTD PMID:29380555 NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992 		JBrowse link
G Myod1 myogenic differentiation 1 decreases expression ISO salubrinal results in decreased expression of MYOD1 protein CTD PMID:29380555 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554 		JBrowse link
G Myog myogenin decreases expression ISO salubrinal results in decreased expression of MYOG protein CTD PMID:29380555 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO salubrinal inhibits the reaction [decamethrin results in decreased expression of NGF protein] CTD PMID:31841155 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [salubrinal results in increased expression of [Cisplatin results in increased expression of NOX4 protein]] CTD PMID:21616140 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; salubrinal inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] CTD PMID:21809093 PMID:22155090 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma multiple interactions ISO [salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein CTD PMID:17187072 NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions
increases expression		 ISO [salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein
salubrinal results in increased expression of PPP1R15A protein		 CTD PMID:17187072 PMID:23690448 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO salubrinal promotes the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] CTD PMID:23892647 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] CTD PMID:22155090 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased degradation of SQSTM1 protein] CTD PMID:20929985 PMID:33127495 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA] CTD PMID:25398788 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein] CTD PMID:25398788 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP salubrinal inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:26446018 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO salubrinal inhibits the reaction [Cyclosporine results in decreased expression of TJP1 protein] CTD PMID:22155090 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO salubrinal promotes the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA] CTD PMID:23892647 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions		 EXP salubrinal results in increased expression of VEGFA mRNA
salubrinal promotes the reaction [Thapsigargin results in increased expression of VEGFA mRNA]		 CTD PMID:28844859 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      chemical role 19421
        oxidising agent 11213
          acetaldehyde 556
            trichloroacetaldehyde 58
              salubrinal 54
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        carboacyl group 17687
                                          univalent carboacyl group 17687
                                            carbamoyl group 17531
                                              carboxamide 17531
                                                alpha,beta-unsaturated carboxylic acid amide 7089
                                                  enamide 7089
                                                    cinnamamides 1347
                                                      cinnamamide 54
                                                        trans-cinnamamide 54
                                                          salubrinal 54
paths to the root