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G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of FN1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; salubrinal inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein] |
CTD |
PMID:25398788 |
|
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
salubrinal inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:25398788 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
salubrinal results in increased expression of ATF3 mRNA |
CTD |
PMID:23690448 |
|
NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
ISO EXP |
[salubrinal co-treated with EPO protein] results in decreased expression of ATF4 protein; salubrinal inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATF4 protein]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of ATF4 protein]]; salubrinal promotes the reaction [Quercetin results in increased expression of ATF4 protein] salubrinal promotes the reaction [Thapsigargin results in increased expression of ATF4 protein]; salubrinal promotes the reaction [Tunicamycin results in increased expression of ATF4 protein] salubrinal results in increased expression of ATF4 protein salubrinal promotes the reaction [Cisplatin results in increased expression of ATF4 protein] |
CTD |
PMID:21616140 PMID:21809093 PMID:23690448 PMID:25611565 PMID:25950987 PMID:28844859 PMID:31022492 |
|
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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G |
Atf6 |
activating transcription factor 6 |
increases expression |
ISO |
salubrinal results in increased expression of ATF6 mRNA |
CTD |
PMID:23958496 |
|
NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO EXP |
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein]]; salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein] salubrinal inhibits the reaction [cadmium acetate results in increased expression of BAX protein] |
CTD |
PMID:21616140 PMID:30605698 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO EXP |
salubrinal inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; salubrinal inhibits the reaction [Quercetin results in decreased expression of BCL2 protein] salubrinal inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein] Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]]; salubrinal promotes the reaction [Cisplatin results in decreased expression of BCL2 protein] |
CTD |
PMID:20686688 PMID:21616140 PMID:25611565 PMID:30605698 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
|
|
G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased expression of BECN1 protein] |
CTD |
PMID:20929985 |
|
NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
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|
G |
Calr |
calreticulin |
multiple interactions |
ISO |
[salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein |
CTD |
PMID:17187072 |
|
NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
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|
G |
Casp12 |
caspase 12 |
multiple interactions |
ISO EXP |
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]]; salubrinal inhibits the reaction [decamethrin results in increased expression of CASP12 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of CASP12 mRNA]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein] salubrinal inhibits the reaction [arsenite results in increased activity of CASP12 protein]; salubrinal inhibits the reaction [Rotenone results in increased cleavage of CASP12 protein] |
CTD |
PMID:18226606 PMID:21616140 PMID:25428620 PMID:26446018 PMID:31841155 |
|
NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
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|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
salubrinal inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; salubrinal inhibits the reaction [MAP3K5 protein results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Paraquat results in increased activity of CASP3 protein] salubrinal inhibits the reaction [Rotenone results in increased expression of CASP3 mRNA]; salubrinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased cleavage of CASP3 protein] salubrinal inhibits the reaction [decamethrin results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [decamethrin results in increased cleavage of and results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of CASP3 mRNA]; salubrinal promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein] |
CTD |
PMID:19735704 PMID:20929985 PMID:21616140 PMID:21809093 PMID:24932542 PMID:25428620 PMID:26446018 PMID:28986289 PMID:30247739 PMID:31841155 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein]]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein] |
CTD |
PMID:21616140 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA] |
CTD |
PMID:23958496 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] |
CTD |
PMID:23958496 |
|
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cyclosporine results in decreased expression of CDH1 protein] |
CTD |
PMID:22155090 |
|
NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
EXP |
salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA] |
CTD |
PMID:23690541 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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|
G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
multiple interactions |
EXP |
salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA] |
CTD |
PMID:23690541 |
|
NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
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|
G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
salubrinal inhibits the reaction [MAP3K5 protein affects the localization of CYCS protein]; salubrinal inhibits the reaction [Paraquat affects the localization of CYCS protein] |
CTD |
PMID:20929985 |
|
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions decreases expression increases expression |
ISO EXP |
EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]; salubrinal inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Quercetin results in increased expression of DDIT3 protein] salubrinal results in decreased expression of DDIT3 protein salubrinal inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Tunicamycin results in increased expression of DDIT3 protein] salubrinal results in increased expression of DDIT3 mRNA Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of DDIT3 protein]]; salubrinal inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Cisplatin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Cyclosporine results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Tacrolimus results in increased expression of DDIT3 protein] |
CTD |
PMID:18305250 PMID:19735704 PMID:20686688 PMID:21616140 PMID:21809093 PMID:23690448 PMID:23958496 PMID:24932542 PMID:25428620 PMID:25611565 PMID:25950987 PMID:26446018 PMID:28844859 PMID:28986289 PMID:29380555 PMID:30508555 PMID:30605698 |
|
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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|
G |
Edem1 |
ER degradation enhancing alpha-mannosidase like protein 1 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Paraquat results in increased expression of EDEM1 protein] |
CTD |
PMID:19735704 |
|
NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
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|
G |
Eif2a |
eukaryotic translation initiation factor 2A |
multiple interactions increases phosphorylation affects phosphorylation increases expression |
ISO EXP |
salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein]; salubrinal inhibits the reaction [EIF2A protein results in decreased susceptibility to nonivamide] salubrinal results in increased phosphorylation of EIF2A protein Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased phosphorylation of EIF2A protein]]; salubrinal promotes the reaction [Cisplatin results in increased phosphorylation of EIF2A protein] salubrinal affects the phosphorylation of EIF2A protein salubrinal results in increased expression of EIF2A protein modified form |
CTD |
PMID:17332266 PMID:17418795 PMID:18305250 PMID:18684481 PMID:20071420 PMID:20686688 PMID:20929985 PMID:21616140 PMID:23690541 PMID:23892647 PMID:27613715 |
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NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
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|
G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases expression increases phosphorylation multiple interactions |
ISO EXP |
salubrinal results in increased expression of EIF2S1 protein modified form salubrinal results in increased phosphorylation of EIF2S1 protein salubrinal inhibits the reaction [Rotenone results in decreased phosphorylation of EIF2S1 protein] [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK1 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK3 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK8 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK9 protein; salubrinal inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form]; salubrinal inhibits the reaction [Rotenone results in decreased phosphorylation of EIF2S1 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of EIF2S1 mRNA]; salubrinal inhibits the reaction [Tunicamycin results in increased expression of EIF2S1 mRNA]; salubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of EIF2S1 protein] [salubrinal co-treated with EPO protein] results in increased phosphorylation of EIF2S1 protein; [salubrinal results in decreased activity of EIF2S1 protein] which results in decreased susceptibility to decamethrin; EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]; EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased phosphorylation of EIF2S1 protein]]; salubrinal promotes the reaction [Cadmium Chloride results in increased phosphorylation of EIF2S1 protein]; salubrinal promotes the reaction [Paraquat results in increased expression of EIF2S1 protein modified form]; salubrinal promotes the reaction [Quercetin results in increased phosphorylation of EIF2S1 protein]; salubrinal results in increased phosphorylation of and results in decreased activity of EIF2S1 protein |
CTD |
PMID:21147958 PMID:21555338 PMID:21809093 PMID:23690448 PMID:24932542 PMID:25170120 PMID:25428620 PMID:25611565 PMID:25950987 PMID:26446018 PMID:28844859 PMID:28986289 PMID:29380555 PMID:30605698 PMID:31022492 |
|
NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
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G |
Epo |
erythropoietin |
multiple interactions |
ISO |
[salubrinal co-treated with EPO protein] results in decreased expression of ATF4 protein; [salubrinal co-treated with EPO protein] results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:23690448 |
|
NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
salubrinal inhibits the reaction [AGT protein results in increased expression of FN1 protein] |
CTD |
PMID:25398788 |
|
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
salubrinal inhibits the reaction [Rotenone results in decreased activity of GSR protein] |
CTD |
PMID:26446018 |
|
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
ISO |
salubrinal promotes the reaction [Cisplatin results in increased expression of HAVCR1 mRNA] |
CTD |
PMID:21616140 |
|
NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
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G |
Hgf |
hepatocyte growth factor |
multiple interactions |
EXP |
salubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]; salubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF protein]; salubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]; salubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF protein] |
CTD |
PMID:28844859 |
|
NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
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|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
ISO EXP |
EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein] salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein] salubrinal results in increased expression of HSPA5 protein salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; salubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HSPA5 protein] |
CTD |
PMID:19735704 PMID:24932542 PMID:25428620 PMID:26446018 PMID:28844859 PMID:28986289 PMID:31022492 |
|
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
affects response to substance multiple interactions |
ISO |
salubrinal affects the susceptibility to MAP3K5 protein salubrinal affects the susceptibility to [Paraquat co-treated with MAP3K5 protein]; salubrinal inhibits the reaction [MAP3K5 protein affects the localization of CYCS protein]; salubrinal inhibits the reaction [MAP3K5 protein results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Paraquat results in increased phosphorylation of and results in increased activity of MAP3K5 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased expression of BECN1 protein] |
CTD |
PMID:19735704 PMID:20929985 |
|
NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO EXP |
salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK1 protein] [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:21147958 PMID:22155090 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:21809093 |
|
NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO EXP |
salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK3 protein] [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:21147958 PMID:22155090 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
|
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP ISO |
[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK8 protein salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein]; salubrinal inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:20686688 PMID:21147958 PMID:21809093 |
|
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO EXP |
salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein] [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:20686688 PMID:21147958 |
|
NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
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G |
Myh3 |
myosin heavy chain 3 |
decreases expression |
ISO |
salubrinal results in decreased expression of MYH3 protein |
CTD |
PMID:29380555 |
|
NCBI chr10:53,621,375...53,645,194
Ensembl chr10:53,621,375...53,645,194
|
|
G |
Myod1 |
myogenic differentiation 1 |
decreases expression |
ISO |
salubrinal results in decreased expression of MYOD1 protein |
CTD |
PMID:29380555 |
|
NCBI chr 1:102,396,538...102,399,248
Ensembl chr 1:102,396,538...102,399,248
|
|
G |
Myog |
myogenin |
decreases expression |
ISO |
salubrinal results in decreased expression of MYOG protein |
CTD |
PMID:29380555 |
|
NCBI chr13:51,126,459...51,129,048
Ensembl chr13:51,126,459...51,129,048
|
|
G |
Ngf |
nerve growth factor |
multiple interactions |
ISO |
salubrinal inhibits the reaction [decamethrin results in decreased expression of NGF protein] |
CTD |
PMID:31841155 |
|
NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
|
|
G |
Nox4 |
NADPH oxidase 4 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [salubrinal results in increased expression of [Cisplatin results in increased expression of NOX4 protein]] |
CTD |
PMID:21616140 |
|
NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; salubrinal inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] |
CTD |
PMID:21809093 PMID:22155090 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
|
|
G |
Ppp1cc |
protein phosphatase 1 catalytic subunit gamma |
multiple interactions |
ISO |
[salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein |
CTD |
PMID:17187072 |
|
NCBI chr12:39,864,302...39,882,030
Ensembl chr12:39,864,295...39,882,030
|
|
G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
multiple interactions increases expression |
ISO |
[salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein salubrinal results in increased expression of PPP1R15A protein |
CTD |
PMID:17187072 PMID:23690448 |
|
NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
|
|
G |
Slc38a2 |
solute carrier family 38, member 2 |
multiple interactions |
ISO |
salubrinal promotes the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] |
CTD |
PMID:23892647 |
|
NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
|
|
G |
Smad2 |
SMAD family member 2 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] |
CTD |
PMID:22155090 |
|
NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased degradation of SQSTM1 protein] |
CTD |
PMID:20929985 |
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NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
EXP |
salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA] |
CTD |
PMID:25398788 |
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NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Quercetin results in decreased phosphorylation of STAT3 protein] |
CTD |
PMID:25611565 |
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NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein] |
CTD |
PMID:25398788 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
EXP |
salubrinal inhibits the reaction [Rotenone results in decreased expression of TH protein] |
CTD |
PMID:26446018 |
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NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
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G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cyclosporine results in decreased expression of TJP1 protein] |
CTD |
PMID:22155090 |
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NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
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G |
Trib3 |
tribbles pseudokinase 3 |
multiple interactions |
ISO |
salubrinal promotes the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA] |
CTD |
PMID:23892647 |
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NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression multiple interactions |
EXP |
salubrinal results in increased expression of VEGFA mRNA salubrinal promotes the reaction [Thapsigargin results in increased expression of VEGFA mRNA] |
CTD |
PMID:28844859 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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