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G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of FN1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; salubrinal inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein] |
CTD |
PMID:25398788 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
salubrinal inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:25398788 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
salubrinal results in increased expression of ATF3 mRNA |
CTD |
PMID:23690448 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
ISO EXP |
[salubrinal co-treated with EPO protein] results in decreased expression of ATF4 protein; salubrinal inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATF4 protein]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of ATF4 protein]]; salubrinal promotes the reaction [T-2 Toxin results in increased expression of ATF4 protein] salubrinal results in increased expression of ATF4 protein salubrinal promotes the reaction [Cisplatin results in increased expression of ATF4 protein] salubrinal promotes the reaction [Thapsigargin results in increased expression of ATF4 protein]; salubrinal promotes the reaction [Tunicamycin results in increased expression of ATF4 protein] |
CTD |
PMID:21616140 PMID:21809093 PMID:23690448 PMID:25950987 PMID:28844859 PMID:31022492 PMID:34673134 More...
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf6 |
activating transcription factor 6 |
increases expression |
ISO |
salubrinal results in increased expression of ATF6 mRNA |
CTD |
PMID:23958496 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO EXP |
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein]]; salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein] salubrinal inhibits the reaction [cadmium acetate results in increased expression of BAX protein] |
CTD |
PMID:21616140 PMID:30605698 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO EXP |
salubrinal inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein] Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]]; salubrinal promotes the reaction [Cisplatin results in decreased expression of BCL2 protein] salubrinal inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein] |
CTD |
PMID:20686688 PMID:21616140 PMID:30605698 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of BECN1 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased expression of BECN1 protein] |
CTD |
PMID:20929985 PMID:33127495 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bnip3 |
BCL2 interacting protein 3 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of BNIP3 protein] |
CTD |
PMID:33127495 |
|
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Calr |
calreticulin |
multiple interactions |
ISO |
[salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein |
CTD |
PMID:17187072 |
|
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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G |
Casp12 |
caspase 12 |
multiple interactions |
ISO EXP |
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]]; salubrinal inhibits the reaction [decamethrin results in increased expression of CASP12 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of CASP12 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of CASP12 mRNA]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein] salubrinal inhibits the reaction [arsenite results in increased activity of CASP12 protein]; salubrinal inhibits the reaction [Rotenone results in increased cleavage of CASP12 protein] salubrinal inhibits the reaction [T-2 Toxin results in increased expression of CASP12 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of CASP12 protein] |
CTD |
PMID:18226606 PMID:21616140 PMID:25428620 PMID:26446018 PMID:31841155 PMID:34673134 More...
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
salubrinal inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; salubrinal inhibits the reaction [MAP3K5 protein results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Paraquat results in increased activity of CASP3 protein] salubrinal inhibits the reaction [decamethrin results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [decamethrin results in increased cleavage of and results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of CASP3 mRNA]; salubrinal promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein] salubrinal inhibits the reaction [Rotenone results in increased expression of CASP3 mRNA]; salubrinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased cleavage of CASP3 protein] |
CTD |
PMID:19735704 PMID:20929985 PMID:21616140 PMID:21809093 PMID:24932542 PMID:25428620 PMID:26446018 PMID:28986289 PMID:30247739 PMID:31841155 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein]]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein] |
CTD |
PMID:21616140 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA] |
CTD |
PMID:23958496 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] |
CTD |
PMID:23958496 |
|
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cyclosporine results in decreased expression of CDH1 protein] |
CTD |
PMID:22155090 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
EXP |
salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA] |
CTD |
PMID:23690541 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
multiple interactions |
EXP |
salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA] |
CTD |
PMID:23690541 |
|
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
salubrinal inhibits the reaction [MAP3K5 protein affects the localization of CYCS protein]; salubrinal inhibits the reaction [Paraquat affects the localization of CYCS protein] |
CTD |
PMID:20929985 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression decreases expression |
ISO EXP |
EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]; salubrinal inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 protein] Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of DDIT3 protein]]; salubrinal inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Cisplatin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Cyclosporine results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Tacrolimus results in increased expression of DDIT3 protein] salubrinal results in increased expression of DDIT3 mRNA salubrinal results in decreased expression of DDIT3 protein salubrinal inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Tunicamycin results in increased expression of DDIT3 protein] |
CTD |
PMID:18305250 PMID:19735704 PMID:20686688 PMID:21616140 PMID:21809093 PMID:23690448 PMID:23958496 PMID:24932542 PMID:25428620 PMID:25950987 PMID:26446018 PMID:28844859 PMID:28986289 PMID:29380555 PMID:30508555 PMID:30605698 PMID:34673134 More...
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Edem1 |
ER degradation enhancing alpha-mannosidase like protein 1 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Paraquat results in increased expression of EDEM1 protein] |
CTD |
PMID:19735704 |
|
NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
multiple interactions increases phosphorylation affects phosphorylation increases expression |
ISO EXP |
salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein]; salubrinal inhibits the reaction [EIF2A protein results in decreased susceptibility to nonivamide] salubrinal results in increased phosphorylation of EIF2A protein Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased phosphorylation of EIF2A protein]]; salubrinal promotes the reaction [Cisplatin results in increased phosphorylation of EIF2A protein] salubrinal affects the phosphorylation of EIF2A protein salubrinal results in increased expression of EIF2A protein modified form |
CTD |
PMID:17332266 PMID:17418795 PMID:18305250 PMID:18684481 PMID:20071420 PMID:20686688 PMID:20929985 PMID:21616140 PMID:23690541 PMID:23892647 PMID:27613715 More...
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|
NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases expression multiple interactions increases phosphorylation |
ISO EXP |
salubrinal results in increased expression of EIF2S1 protein modified form [salubrinal co-treated with EPO protein] results in increased phosphorylation of EIF2S1 protein; [salubrinal results in decreased activity of EIF2S1 protein] which results in decreased susceptibility to decamethrin; EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]; EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased phosphorylation of EIF2S1 protein]]; salubrinal promotes the reaction [Cadmium Chloride results in increased phosphorylation of EIF2S1 protein]; salubrinal promotes the reaction [Paraquat results in increased expression of EIF2S1 protein modified form]; salubrinal results in increased phosphorylation of and results in decreased activity of EIF2S1 protein salubrinal results in increased phosphorylation of EIF2S1 protein [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK1 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK3 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK8 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK9 protein; salubrinal inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form]; salubrinal inhibits the reaction [Rotenone results in decreased phosphorylation of EIF2S1 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of EIF2S1 mRNA]; salubrinal inhibits the reaction [Tunicamycin results in increased expression of EIF2S1 mRNA]; salubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of EIF2S1 protein] salubrinal inhibits the reaction [Rotenone results in decreased phosphorylation of EIF2S1 protein]; salubrinal promotes the reaction [T-2 Toxin results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:21147958 PMID:21555338 PMID:21809093 PMID:23690448 PMID:24932542 PMID:25170120 PMID:25428620 PMID:25950987 PMID:26446018 PMID:28844859 PMID:28986289 PMID:29380555 PMID:30605698 PMID:31022492 PMID:34673134 More...
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Epo |
erythropoietin |
multiple interactions |
ISO |
[salubrinal co-treated with EPO protein] results in decreased expression of ATF4 protein; [salubrinal co-treated with EPO protein] results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:23690448 |
|
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
salubrinal inhibits the reaction [AGT protein results in increased expression of FN1 protein] |
CTD |
PMID:25398788 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Foxo3 |
forkhead box O3 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of FOXO3 protein] |
CTD |
PMID:33127495 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
salubrinal inhibits the reaction [Rotenone results in decreased activity of GSR protein] |
CTD |
PMID:26446018 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
ISO |
salubrinal promotes the reaction [Cisplatin results in increased expression of HAVCR1 mRNA] |
CTD |
PMID:21616140 |
|
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hgf |
hepatocyte growth factor |
multiple interactions |
EXP |
salubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]; salubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF protein]; salubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]; salubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF protein] |
CTD |
PMID:28844859 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
ISO EXP |
EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein] salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; salubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HSPA5 protein] salubrinal results in increased expression of HSPA5 protein salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein] |
CTD |
PMID:19735704 PMID:24932542 PMID:25428620 PMID:26446018 PMID:28844859 PMID:28986289 PMID:31022492 PMID:34673134 More...
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
affects response to substance multiple interactions |
ISO |
salubrinal affects the susceptibility to MAP3K5 protein salubrinal affects the susceptibility to [Paraquat co-treated with MAP3K5 protein]; salubrinal inhibits the reaction [MAP3K5 protein affects the localization of CYCS protein]; salubrinal inhibits the reaction [MAP3K5 protein results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Paraquat results in increased phosphorylation of and results in increased activity of MAP3K5 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased expression of BECN1 protein] |
CTD |
PMID:19735704 PMID:20929985 |
|
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO EXP |
salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK1 protein] [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:21147958 PMID:22155090 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:21809093 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO EXP |
salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK3 protein] [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:21147958 PMID:22155090 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP ISO |
[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK8 protein salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein]; salubrinal inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:20686688 PMID:21147958 PMID:21809093 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO EXP |
salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein] [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:20686688 PMID:21147958 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
ISO |
[salubrinal co-treated with T-2 Toxin] results in increased expression of MMP13 mRNA; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein] |
CTD |
PMID:34673134 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G |
Myh3 |
myosin heavy chain 3 |
decreases expression |
ISO |
salubrinal results in decreased expression of MYH3 protein |
CTD |
PMID:29380555 |
|
NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992
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G |
Myod1 |
myogenic differentiation 1 |
decreases expression |
ISO |
salubrinal results in decreased expression of MYOD1 protein |
CTD |
PMID:29380555 |
|
NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
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G |
Myog |
myogenin |
decreases expression |
ISO |
salubrinal results in decreased expression of MYOG protein |
CTD |
PMID:29380555 |
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NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
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G |
Ngf |
nerve growth factor |
multiple interactions |
ISO |
salubrinal inhibits the reaction [decamethrin results in decreased expression of NGF protein] |
CTD |
PMID:31841155 |
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NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [salubrinal results in increased expression of [Cisplatin results in increased expression of NOX4 protein]] |
CTD |
PMID:21616140 |
|
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; salubrinal inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] |
CTD |
PMID:21809093 PMID:22155090 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ppp1cc |
protein phosphatase 1 catalytic subunit gamma |
multiple interactions |
ISO |
[salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein |
CTD |
PMID:17187072 |
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NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
multiple interactions increases expression |
ISO |
[salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein salubrinal results in increased expression of PPP1R15A protein |
CTD |
PMID:17187072 PMID:23690448 |
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NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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G |
Slc38a2 |
solute carrier family 38, member 2 |
multiple interactions |
ISO |
salubrinal promotes the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] |
CTD |
PMID:23892647 |
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NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
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G |
Smad2 |
SMAD family member 2 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] |
CTD |
PMID:22155090 |
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NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased degradation of SQSTM1 protein] |
CTD |
PMID:20929985 PMID:33127495 |
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NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
EXP |
salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA] |
CTD |
PMID:25398788 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein] |
CTD |
PMID:25398788 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
EXP |
salubrinal inhibits the reaction [Rotenone results in decreased expression of TH protein] |
CTD |
PMID:26446018 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
ISO |
salubrinal inhibits the reaction [Cyclosporine results in decreased expression of TJP1 protein] |
CTD |
PMID:22155090 |
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NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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G |
Trib3 |
tribbles pseudokinase 3 |
multiple interactions |
ISO |
salubrinal promotes the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA] |
CTD |
PMID:23892647 |
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NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression multiple interactions |
EXP |
salubrinal results in increased expression of VEGFA mRNA salubrinal promotes the reaction [Thapsigargin results in increased expression of VEGFA mRNA] |
CTD |
PMID:28844859 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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