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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:violacein
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Accession:CHEBI:131914 term browser browse the term
Definition:A member of the class of hydroxyindoles resulting from the formal oxidative coupling between the 3-position of 1,3-dihydro-2H-indol-2-one and the 3-position of 1,3-dihydro-2H-pyrrol-2-one, which is substituted at the 5 position by a 5-hydroxy-1H-indol-3-yl group, where the newly-formed double bond has E configuration. It is a purple chromobacterial pigment that has antibacterial, antifungal, antiprotozoan, and anticancer properties.
Synonyms:exact_synonym: (3E)-3-[5-(5-hydroxy-1H-indol-3-yl)-2-oxo-1,2-dihydro-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one
 related_synonym: Formula=C20H13N3O3;   InChI=1S/C20H13N3O3/c24-10-5-6-15-12(7-10)14(9-21-15)17-8-13(19(25)23-17)18-11-3-1-2-4-16(11)22-20(18)26/h1-9,21,24H,(H,22,26)(H,23,25)/b18-13+;   InChIKey=XAPNKXIRQFHCHN-QGOAFFKASA-N;   SMILES=OC1=CC=C2NC=C(C3=C\\C(C(=O)N3)=C3/C(=O)NC4=CC=CC=C34)C2=C1
 xref: CAS:548-54-9;   KEGG:C21136
 xref_mesh: MESH:C063155
 xref: MetaCyc:VIOLACEIN;   PMID:21779844;   PMID:25592762;   PMID:25652759;   PMID:26339614;   PMID:26428920;   PMID:26521020;   PMID:26916415;   Reaxys:49923



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violacein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 increases activity ISO violacein results in increased activity of CASP2 protein CTD PMID:20416285 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 increases activity ISO violacein results in increased activity of CASP3 protein CTD PMID:20416285 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO violacein results in increased activity of CASP9 protein CTD PMID:20416285 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        antimicrobial agent 18166
          antibacterial agent 15462
            violacein 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                lactam 8395
                                                  gamma-lactam 6653
                                                    oxindoles 5886
                                                      violacein 3
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