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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diethyl (1-\{[(2-chloroethyl)(nitroso)carbamoyl]amino\}ethyl)phosphonate
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Accession:CHEBI:131852 term browser browse the term
Definition:A member of the class of N-nitrosoureas that is ethyl diethylphosphonate in the hydrogen at position 1 of the ethyl group attached to the phosphorus has been replaced by a [(2-chloroethyl)(nitroso)carbamoyl]amino group.
Synonyms:related_synonym: Formula=C9H19ClN3O5P;   InChI=1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14);   InChIKey=YAKWPXVTIGTRJH-UHFFFAOYSA-N;   SMILES=C(NC(P(=O)(OCC)OCC)C)(N(N=O)CCCl)=O


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO fotemustine results in increased expression of CDKN1A mRNA CTD PMID:25125662 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO fotemustine results in increased expression of FAS mRNA CTD PMID:25125662 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of FOS mRNA; fotemustine results in increased expression of FOS protein
CTD PMID:23578789 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO fotemustine results in increased expression of GADD45A mRNA CTD PMID:25125662 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G H2ax H2A.X variant histone increases expression ISO fotemustine results in increased expression of H2AX protein modified form CTD PMID:25125662 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of JUN mRNA; fotemustine results in increased expression of JUN protein
CTD PMID:23578789 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases response to substance ISO MGMT protein results in decreased susceptibility to fotemustine CTD PMID:12970393 PMID:16039682 PMID:20556481 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Polh DNA polymerase eta multiple interactions
decreases response to substance
increases expression
ISO Dactinomycin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; fotemustine promotes the reaction [TP53 protein binds to POLH promoter]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]
POLH protein results in decreased susceptibility to fotemustine
fotemustine results in increased expression of POLH mRNA; fotemustine results in increased expression of POLH protein
CTD PMID:25125662 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO fotemustine promotes the reaction [TP53 protein binds to POLH promoter]
fotemustine results in increased expression of TP53 protein; fotemustine results in increased expression of TP53 protein modified form
CTD PMID:25125662 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trex1 three prime repair exonuclease 1 multiple interactions
affects response to substance
increases expression
ISO FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]; fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
TREX1 affects the susceptibility to fotemustine
fotemustine results in increased expression of TREX1 mRNA; fotemustine results in increased expression of TREX1 protein
CTD PMID:23578789 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      group 19741
        inorganic group 19271
          nitroso group 5011
            nitroso compound 5011
              N-nitrosoureas 2039
                diethyl (1-\{[(2-chloroethyl)(nitroso)carbamoyl]amino\}ethyl)phosphonate 10
                  (R)-fotemustine + 10
                  (S)-fotemustine + 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                monocarboxylic acid amide 15008
                                                  urea 5110
                                                    ureas 5108
                                                      N-nitrosoureas 2039
                                                        diethyl (1-\{[(2-chloroethyl)(nitroso)carbamoyl]amino\}ethyl)phosphonate 10
                                                          (R)-fotemustine + 10
                                                          (S)-fotemustine + 10
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