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Accession:CHEBI:131848 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-fotemustine. It is an alkylating agent used in the treatment of malignant melanoma.
Synonyms:related_synonym: (+-)-diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate;   Formula=C9H19ClN3O5P;   Muphoran;   Mustoforan;   S 10036;   Servier-10036;   diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate;   fotemustina;   fotemustinum;   rac-fotemustine
 alt_id: MESH:C054368
 xref: CAS:92118-27-9 "ChemIDplus";   KEGG:D07255
 xref_mesh: MESH:C054368
 xref: PMID:15020614 "Europe PMC";   PMID:23560594 "Europe PMC";   PMID:24023343 "Europe PMC";   PMID:24800248 "Europe PMC";   PMID:25538176 "Europe PMC";   PMID:25702193 "Europe PMC";   PMID:2627116 "Europe PMC";   PMID:26458240 "Europe PMC";   PMID:26542177 "Europe PMC";   PMID:26750128 "Europe PMC";   PMID:26951379 "Europe PMC";   PMID:27057436 "Europe PMC";   Patent:FR2536075;   Patent:US4567169;   Reaxys:8626774 "Reaxys";   Wikipedia:Fotemustine

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fotemustine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 1 209,237,255 209,464,189 RGD:6480464
G Polh DNA polymerase eta JBrowse link 9 17,163,354 17,198,006 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Trex1 three prime repair exonuclease 1 JBrowse link 8 117,796,127 117,797,427 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    chemical entity 19655
      chemical substance 10730
        mixture 9936
          racemate 8664
            fotemustine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        carboacyl group 16941
                                          univalent carboacyl group 16941
                                            carbamoyl group 16621
                                              carboxamide 16621
                                                monocarboxylic acid amide 13181
                                                  urea 4932
                                                    ureas 4929
                                                      N-nitrosoureas 1872
                                                        diethyl (1-\{[(2-chloroethyl)(nitroso)carbamoyl]amino\}ethyl)phosphonate 10
                                                          (R)-fotemustine 10
                                                            fotemustine 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.