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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fotemustine
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Accession:CHEBI:131848 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-fotemustine. It is an alkylating agent used in the treatment of malignant melanoma.
Synonyms:related_synonym: (+-)-diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate;   Formula=C9H19ClN3O5P;   Muphoran;   Mustoforan;   S 10036;   Servier-10036;   diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate;   fotemustina;   fotemustinum;   rac-fotemustine
 alt_id: MESH:C054368
 xref: CAS:92118-27-9;   KEGG:D07255
 xref_mesh: MESH:C054368
 xref: PMID:15020614;   PMID:23560594;   PMID:24023343;   PMID:24800248;   PMID:25538176;   PMID:25702193;   PMID:2627116;   PMID:26458240;   PMID:26542177;   PMID:26750128;   PMID:26951379;   PMID:27057436;   Patent:FR2536075;   Patent:US4567169;   Reaxys:8626774;   Wikipedia:Fotemustine



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fotemustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO fotemustine results in increased expression of CDKN1A mRNA CTD PMID:25125662 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO fotemustine results in increased expression of FAS mRNA CTD PMID:25125662 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of FOS mRNA; fotemustine results in increased expression of FOS protein
CTD PMID:23578789 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO fotemustine results in increased expression of GADD45A mRNA CTD PMID:25125662 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G H2ax H2A.X variant histone increases expression ISO fotemustine results in increased expression of H2AX protein modified form CTD PMID:25125662 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO fotemustine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of JUN mRNA; fotemustine results in increased expression of JUN protein
CTD PMID:23578789 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases response to substance ISO MGMT protein results in decreased susceptibility to fotemustine CTD PMID:12970393 PMID:16039682 PMID:20556481 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Polh DNA polymerase eta multiple interactions
decreases response to substance
increases expression
ISO Dactinomycin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; fotemustine promotes the reaction [TP53 protein binds to POLH promoter]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]
POLH protein results in decreased susceptibility to fotemustine
fotemustine results in increased expression of POLH mRNA; fotemustine results in increased expression of POLH protein
CTD PMID:25125662 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO fotemustine promotes the reaction [TP53 protein binds to POLH promoter]
fotemustine results in increased expression of TP53 protein; fotemustine results in increased expression of TP53 protein modified form
CTD PMID:25125662 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trex1 three prime repair exonuclease 1 multiple interactions
affects response to substance
increases expression
ISO FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]; fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
TREX1 affects the susceptibility to fotemustine
fotemustine results in increased expression of TREX1 mRNA; fotemustine results in increased expression of TREX1 protein
CTD PMID:23578789 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    chemical entity 20088
      chemical substance 13325
        mixture 12455
          racemate 10556
            fotemustine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        carboacyl group 17730
                                          univalent carboacyl group 17710
                                            carbamoyl group 17550
                                              carboxamide 17570
                                                monocarboxylic acid amide 15534
                                                  urea 5141
                                                    ureas 5134
                                                      N-nitrosoureas 2067
                                                        diethyl (1-\{[(2-chloroethyl)(nitroso)carbamoyl]amino\}ethyl)phosphonate 11
                                                          (R)-fotemustine 11
                                                            fotemustine 11
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