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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:meldonium
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Accession:CHEBI:131843 term browser browse the term
Definition:An ammonium betaine that is beta-alaninate in which one of the amino hydrogens is replaced by a trimethylamino group. A clinically used cardioprotective drug that is used for treatment of heart failure, myocardial infarction, arrhythmia, atherosclerosis and diabetes.
Synonyms:exact_synonym: 3-(2,2,2-trimethyldiazan-2-ium-1-yl)propanoate
 related_synonym: 2-(2-carboxyethyl)-1,1,1-trimethyldiazanium;   3-(2,2,2-Trimethyldiazaniumyl)propanoate;   3-(2,2,2-Trimethylhydrazine)propionate;   Formula=C6H14N2O2;   InChI=1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3;   InChIKey=PVBQYTCFVWZSJK-UHFFFAOYSA-N;   SMILES=[N+](NCCC([O-])=O)(C)(C)C;   mildronate
 xref: CAS:76144-81-5;   Drug_Central:3995;   KEGG:D10504
 xref_mesh: MESH:C050147
 xref: MetaCyc:CPD-10661;   PDBeChem:REE;   PMID:23238051;   PMID:24124882;   PMID:24273007;   PMID:24571165;   PMID:24729295;   PMID:24754070;   PMID:24864465;   PMID:25001658;   PMID:25177785;   PMID:25177814;   PMID:25177815;   PMID:25446926;   PMID:25675721;   PMID:25702409;   PMID:25847280;   PMID:25902653;   PMID:26697890;   PMID:26761970;   PMID:26850121;   PMID:26961537;   PMID:27015859;   Reaxys:3938272;   Wikipedia:Meldonium


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meldonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadl acyl-CoA dehydrogenase, long chain increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of ACADL mRNA CTD PMID:32389661 NCBI chr 9:68,333,981...68,372,149 JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of ACADM mRNA CTD PMID:32389661 NCBI chr 2:242,858,865...242,883,036 JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of ACADVL mRNA CTD PMID:32389661 NCBI chr10:54,732,875...54,738,102 JBrowse link
G Acox1 acyl-CoA oxidase 1 affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of ACOX1 mRNA CTD PMID:32389661 NCBI chr10:101,406,197...101,431,242 JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of CPT1B mRNA CTD PMID:32389661 NCBI chr 7:120,491,354...120,500,833 JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of CPT1C mRNA CTD PMID:32389661 NCBI chr 1:95,442,814...95,457,347 JBrowse link
G Hk1 hexokinase 1 increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of HK1 mRNA CTD PMID:32389661 NCBI chr20:30,230,488...30,332,161 JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of PDK1 mRNA CTD PMID:32389661 NCBI chr 3:56,705,824...56,733,040 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of PPARA mRNA CTD PMID:32389661 NCBI chr 7:116,832,405...116,900,878 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression EXP
ISO
3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of PPARGC1A mRNA CTD PMID:27559315 PMID:32389661 NCBI chr14:58,860,752...59,516,525 JBrowse link
G Ppargc1b PPARG coactivator 1 beta affects expression EXP 3-(2,2,2-trimethylhydrazine)propionate affects the expression of PPARGC1B mRNA CTD PMID:27559315 NCBI chr18:54,758,891...54,861,103 JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases uptake ISO
EXP
SLC22A5 protein results in increased uptake of 3-(2,2,2-trimethylhydrazine)propionate CTD PMID:18981167 NCBI chr10:38,008,303...38,035,474 JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of SLC2A4 mRNA CTD PMID:32389661 NCBI chr10:54,666,015...54,671,581 JBrowse link
G Slc5a2 solute carrier family 5 member 2 affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of SLC5A2 mRNA CTD PMID:32389661 NCBI chr 1:182,847,185...182,853,309 JBrowse link
G Tfam transcription factor A, mitochondrial decreases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of TFAM mRNA CTD PMID:27559315 NCBI chr20:17,356,243...17,368,293 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      application 19396
        pharmaceutical 19294
          drug 19294
            protective agent 16479
              neuroprotective agent 15494
                meldonium 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    main group molecular entity 19651
                      s-block molecular entity 19418
                        hydrogen molecular entity 19413
                          hydrides 18746
                            inorganic hydride 17471
                              pnictogen hydride 17448
                                nitrogen hydride 17302
                                  ammonium 8214
                                    ammonium ion derivative 8210
                                      quaternary ammonium ion 5107
                                        quaternary nitrogen compound 619
                                          ammonium betaine 337
                                            meldonium 15
paths to the root