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ONTOLOGY REPORT - ANNOTATIONS


Term:meldonium
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Accession:CHEBI:131843 term browser browse the term
Definition:An ammonium betaine that is beta-alaninate in which one of the amino hydrogens is replaced by a trimethylamino group. A clinically used cardioprotective drug that is used for treatment of heart failure, myocardial infarction, arrhythmia, atherosclerosis and diabetes.
Synonyms:exact_synonym: 3-(2,2,2-trimethyldiazan-2-ium-1-yl)propanoate
 related_synonym: 2-(2-carboxyethyl)-1,1,1-trimethyldiazanium;   3-(2,2,2-Trimethyldiazaniumyl)propanoate;   3-(2,2,2-Trimethylhydrazine)propionate;   Formula=C6H14N2O2;   InChI=1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3;   InChIKey=PVBQYTCFVWZSJK-UHFFFAOYSA-N;   SMILES=[N+](NCCC([O-])=O)(C)(C)C;   mildronate
 xref: CAS:76144-81-5;   Drug_Central:3995;   KEGG:D10504
 xref_mesh: MESH:C050147
 xref: MetaCyc:CPD-10661;   PDBeChem:REE;   PMID:23238051;   PMID:24124882;   PMID:24273007;   PMID:24571165;   PMID:24729295;   PMID:24754070;   PMID:24864465;   PMID:25001658;   PMID:25177785;   PMID:25177814;   PMID:25177815;   PMID:25446926;   PMID:25675721;   PMID:25702409;   PMID:25847280;   PMID:25902653;   PMID:26697890;   PMID:26761970;   PMID:26850121;   PMID:26961537;   PMID:27015859;   Reaxys:3938272;   Wikipedia:Meldonium


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meldonium term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Ppargc1b PPARG coactivator 1 beta JBrowse link 18 56,626,725 56,650,524 RGD:6480464
G Slc22a5 solute carrier family 22 member 5 JBrowse link 10 39,201,101 39,228,090 RGD:6480464
G Tfam transcription factor A, mitochondrial JBrowse link 20 18,594,057 18,606,106 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      application 19385
        pharmaceutical 19254
          drug 19254
            protective agent 16364
              neuroprotective agent 15481
                meldonium 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    main group molecular entity 19674
                      s-block molecular entity 19416
                        hydrogen molecular entity 19407
                          hydrides 18389
                            inorganic hydride 17221
                              pnictogen hydride 17184
                                nitrogen hydride 17018
                                  ammonium 8221
                                    ammonium ion derivative 8216
                                      quaternary ammonium ion 5061
                                        quaternary nitrogen compound 555
                                          ammonium betaine 271
                                            meldonium 4
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