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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:melatonin receptor antagonist
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Accession:CHEBI:131790 term browser browse the term
Definition:An antagonist that binds to and deactivates melatonin receptors.
Synonyms:related_synonym: melatonin receptor antagonists
 xref: Wikipedia:Melatonin_receptor



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luzindole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased activity of CAT protein] CTD PMID:23554006 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gast gastrin multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased expression of GAST] CTD PMID:12074098 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased activity of GSR protein] CTD PMID:23554006 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Mtnr1a melatonin receptor 1A multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein] CTD PMID:28238930 NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919
JBrowse link
G Mtnr1b melatonin receptor 1B multiple interactions ISO
EXP
[luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin; luzindole binds to and results in decreased activity of MTNR1B protein
luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]
CTD PMID:11270484 PMID:21473625 PMID:28238930 NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]] CTD PMID:26283214 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of PPARG protein]; luzindole inhibits the reaction [Pioglitazone results in increased expression of PPARG protein] CTD PMID:29734669 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]] CTD PMID:25159133 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prnp prion protein multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of PRNP protein]; luzindole inhibits the reaction [Pioglitazone results in increased expression of PRNP protein] CTD PMID:29734669 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]] CTD PMID:26283214 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]] CTD PMID:25159133 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased activity of SOD1 protein] CTD PMID:23554006 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased activity of SOD2 protein] CTD PMID:23554006 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]] CTD PMID:26283214 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20072
    role 20026
      biological role 20025
        pharmacological role 19122
          antagonist 16754
            melatonin receptor antagonist 14
              luzindole 14
paths to the root