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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:xestospongin C
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Accession:CHEBI:131784 term browser browse the term
Definition:An organic heteropentacyclic compound that is isolated from the marine sponge Xestospongia exigua.
Synonyms:exact_synonym: (4aR,11R,12aS,16aS,23R,24aS)-icosahydro-2H,5H,12aH,14H-1,23:11,13-diethano[1,11]dioxacycloicosino[10,9-b:20,19-b']dipyridine
 related_synonym: Araguspongin E;   Araguspongine E;   Formula=C28H50N2O2;   InChI=1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m1/s1;   InChIKey=PQYOPBRFUUEHRC-HCKQMYSWSA-N;   SMILES=[C@@]12(N3CC[C@H](O1)CCCCCC[C@H]4[C@@]5(O[C@H](CCCCCC[C@H]2CCC3)CCN5CCC4)[H])[H]
 xref: CAS:88903-69-9
 xref_mesh: MESH:C511704
 xref: PMID:10821794;   PMID:25580621;   PMID:26912139;   PMID:27031052;   PMID:27038234;   PMID:27062708;   Reaxys:7626600;   Reaxys:9307275


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xestospongin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP xestospongin C inhibits the reaction [AGT protein affects the localization of Calcium] CTD PMID:21613610 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Cd14 CD14 molecule increases expression ISO xestospongin C results in increased expression of CD14 protein CTD PMID:23395717 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP xestospongin C inhibits the reaction [Calcium results in decreased secretion of CYCS protein] CTD PMID:15345483 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO xestospongin C inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid] CTD PMID:19014389 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Htt huntingtin multiple interactions ISO xestospongin C inhibits the reaction [Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]] CTD PMID:21059370 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO xestospongin C results in increased expression of ITGAM protein CTD PMID:23395717 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO xestospongin C inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] CTD PMID:17241155 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 multiple interactions ISO xestospongin C inhibits the reaction [[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium] CTD PMID:15201137 NCBI chr 4:180,423,452...180,800,088
Ensembl chr 4:180,538,389...180,722,358
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression ISO xestospongin C results in increased expression of MAPK1 protein modified form CTD PMID:23395717 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO xestospongin C results in increased expression of MAPK3 protein modified form CTD PMID:23395717 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP xestospongin C inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16787574 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19801
    role 19747
      biological role 19746
        pharmacological role 18825
          antagonist 16212
            IP3 receptor antagonist 17
              xestospongin C 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19801
    subatomic particle 19797
      composite particle 19797
        hadron 19797
          baryon 19797
            nucleon 19797
              atomic nucleus 19797
                atom 19797
                  main group element atom 19684
                    main group molecular entity 19684
                      s-block molecular entity 19428
                        hydrogen molecular entity 19419
                          hydrides 18460
                            inorganic hydride 17428
                              pnictogen hydride 17400
                                nitrogen hydride 17241
                                  azane 16958
                                    ammonia 16957
                                      organic amino compound 16956
                                        tertiary amino compound 8638
                                          xestospongin C 11
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