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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:xestospongin C
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Accession:CHEBI:131784 term browser browse the term
Definition:An organic heteropentacyclic compound that is isolated from the marine sponge Xestospongia exigua.
Synonyms:exact_synonym: (4aR,11R,12aS,16aS,23R,24aS)-icosahydro-2H,5H,12aH,14H-1,23:11,13-diethano[1,11]dioxacycloicosino[10,9-b:20,19-b']dipyridine
 related_synonym: Araguspongin E;   Araguspongine E;   Formula=C28H50N2O2;   InChI=1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m1/s1;   InChIKey=PQYOPBRFUUEHRC-HCKQMYSWSA-N;   SMILES=[C@@]12(N3CC[C@H](O1)CCCCCC[C@H]4[C@@]5(O[C@H](CCCCCC[C@H]2CCC3)CCN5CCC4)[H])[H]
 xref: CAS:88903-69-9
 xref_mesh: MESH:C511704
 xref: PMID:10821794;   PMID:25580621;   PMID:26912139;   PMID:27031052;   PMID:27038234;   PMID:27062708;   Reaxys:7626600;   Reaxys:9307275

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xestospongin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP xestospongin C inhibits the reaction [AGT protein affects the localization of Calcium] CTD PMID:21613610 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Cd14 CD14 molecule increases expression ISO xestospongin C results in increased expression of CD14 protein CTD PMID:23395717 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP xestospongin C inhibits the reaction [Calcium results in decreased secretion of CYCS protein] CTD PMID:15345483 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO xestospongin C inhibits the reaction [Homocysteine results in increased expression of and results in increased phosphorylation of DNM1L protein] CTD PMID:33751715 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO xestospongin C inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid] CTD PMID:19014389 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Htt huntingtin multiple interactions ISO xestospongin C inhibits the reaction [Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]] CTD PMID:21059370 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO xestospongin C results in increased expression of ITGAM protein CTD PMID:23395717 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO xestospongin C inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] CTD PMID:17241155 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 multiple interactions ISO xestospongin C inhibits the reaction [[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium] CTD PMID:15201137 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression ISO xestospongin C results in increased expression of MAPK1 protein modified form CTD PMID:23395717 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO xestospongin C results in increased expression of MAPK3 protein modified form CTD PMID:23395717 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP xestospongin C inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16787574 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        pharmacological role 18847
          antagonist 16277
            IP3 receptor antagonist 19
              xestospongin C 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8679
                                          xestospongin C 12
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