CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: xestospongin C
Accession: CHEBI:131784
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Definition: An organic heteropentacyclic compound that is isolated from the marine sponge Xestospongia exigua.
Synonyms: exact_synonym: (4aR,11R,12aS,16aS,23R,24aS)-icosahydro-2H,5H,12aH,14H-1,23:11,13-diethano[1,11]dioxacycloicosino[10,9-b:20,19-b']dipyridine
related_synonym: Araguspongin E; Araguspongine E; Formula=C28H50N2O2; InChI=1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m1/s1; InChIKey=PQYOPBRFUUEHRC-HCKQMYSWSA-N; SMILES=[C@@]12(N3CC[C@H](O1)CCCCCC[C@H]4[C@@]5(O[C@H](CCCCCC[C@H]2CCC3)CCN5CCC4)[H])[H]
xref: CAS:88903-69-9
xref_mesh: MESH:C511704
xref: PMID:10821794; PMID:25580621; PMID:26912139; PMID:27031052; PMID:27038234; PMID:27062708; Reaxys:7626600; Reaxys:9307275
G
Agt
angiotensinogen
multiple interactions
EXP
xestospongin C inhibits the reaction [AGT protein affects the localization of Calcium]
CTD
PMID:21613610
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Cd14
CD14 molecule
increases expression
ISO
xestospongin C results in increased expression of CD14 protein
CTD
PMID:23395717
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
G
Cycs
cytochrome c, somatic
multiple interactions
EXP
xestospongin C inhibits the reaction [Calcium results in decreased secretion of CYCS protein]
CTD
PMID:15345483
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
G
Dnm1l
dynamin 1-like
multiple interactions
ISO
xestospongin C inhibits the reaction [Homocysteine results in increased expression of and results in increased phosphorylation of DNM1L protein]
CTD
PMID:33751715
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
G
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
multiple interactions
ISO
xestospongin C inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]
CTD
PMID:19014389
NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
G
Htt
huntingtin
multiple interactions
ISO
xestospongin C inhibits the reaction [Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]]
CTD
PMID:21059370
NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070
G
Itgam
integrin subunit alpha M
increases expression
ISO
xestospongin C results in increased expression of ITGAM protein
CTD
PMID:23395717
NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
G
Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
multiple interactions
ISO
xestospongin C inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]
CTD
PMID:17241155
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
G
Itpr2
inositol 1,4,5-trisphosphate receptor, type 2
multiple interactions
ISO
xestospongin C inhibits the reaction [[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium]
CTD
PMID:15201137
NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
G
Mapk1
mitogen activated protein kinase 1
increases expression
ISO
xestospongin C results in increased expression of MAPK1 protein modified form
CTD
PMID:23395717
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
increases expression
ISO
xestospongin C results in increased expression of MAPK3 protein modified form
CTD
PMID:23395717
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Nppa
natriuretic peptide A
multiple interactions
EXP
xestospongin C inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD
PMID:16787574
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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