stigmastane derivative - Ontology Report

[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA]

NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946

Abcg5

ATP binding cassette subfamily G member 5

multiple interactions
decreases expression

[Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG5 mRNA
Stigmasterol results in decreased expression of ABCG5 mRNA

NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207

Abcg8

ATP binding cassette subfamily G member 8

multiple interactions
decreases expression

[Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG8 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG8 mRNA
Stigmasterol results in decreased expression of ABCG8 mRNA

NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708

Acat1

acetyl-CoA acetyltransferase 1

multiple interactions

[Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ACAT1 mRNA

NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884

Ankrd1

ankyrin repeat domain 1

multiple interactions

[NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of ANKRD1 mRNA

NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548

Apoa1

apolipoprotein A1

multiple interactions

[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA]; Stigmasterol promotes the reaction [GW 4064 results in increased expression of APOA1 mRNA]

NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875

Brinp3

BMP/retinoic acid inducible neural specific 3

multiple interactions

[NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of BRINP3 mRNA

NCBI chr13:63,526,486...63,959,390
Ensembl chr13:63,526,486...63,959,332

Cldn11

claudin 11

multiple interactions

[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA]

NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846

Dnmt3l

DNA methyltransferase 3 like

multiple interactions

[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA]

NCBI chr20:11,344,513...11,359,090
Ensembl chr20:11,344,514...11,359,090

Esr1

estrogen receptor 1

multiple interactions

[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA]

NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796

Fshr

follicle stimulating hormone receptor

multiple interactions

Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of FSHR mRNA]

NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817

Gabarap

GABA type A receptor-associated protein

decreases expression

Stigmasterol results in decreased expression of GABARAP mRNA

NCBI chr10:56,601,288...56,604,223
Ensembl chr10:56,601,288...56,604,221

Gfra1

GDNF family receptor alpha 1

multiple interactions

[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of GFRA1 mRNA]

NCBI chr 1:279,203,046...279,572,789

Hmgcr

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
increases expression

[Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of HMGCR mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA
Stigmasterol results in increased expression of HMGCR mRNA

NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654

Hoxa5

homeo box A5

multiple interactions

[NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of HOXA5 mRNA

NCBI chr 4:82,170,383...82,174,788
Ensembl chr 4:82,170,387...82,173,207

Ifi35

interferon-induced protein 35

decreases expression

Stigmasterol results in decreased expression of IFI35 mRNA

NCBI chr10:89,358,376...89,366,628
Ensembl chr10:89,358,376...89,366,626

Il10

interleukin 10

increases secretion

Stigmasterol results in increased secretion of IL10 protein

NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392

Il6

interleukin 6

multiple interactions

Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]

PMID:23535395

NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807

Kng2

kininogen 2

multiple interactions

[Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of NPC1L1 mRNA

NCBI chr11:81,509,185...81,516,759

Mybpc2

myosin binding protein C2

multiple interactions

[NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of MYBPC2 mRNA

NCBI chr 1:100,506,704...100,530,201
Ensembl chr 1:100,506,704...100,530,183

Nanog

Nanog homeobox

decreases expression
multiple interactions

Stigmasterol results in decreased expression of NANOG mRNA
[bisphenol A co-treated with Stigmasterol] results in decreased expression of NANOG mRNA; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NANOG mRNA]

NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268

Nos2

nitric oxide synthase 2

multiple interactions

Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:23535395

NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190

Npc1l1

NPC1 like intracellular cholesterol transporter 1

multiple interactions

[Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of NPC1L1 mRNA; [Stigmasterol co-treated with Rotenone] results in increased expression of NPC1L1 mRNA

NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694

Nr0b1

nuclear receptor subfamily 0, group B, member 1

multiple interactions
decreases expression

[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA; GW 4064 promotes the reaction [Stigmasterol results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of NR0B1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NR0B1 mRNA]

NCBI chr X:54,734,385...54,738,513
Ensembl chr X:54,734,385...54,738,513

Nr0b2

nuclear receptor subfamily 0, group B, member 2

multiple interactions

Stigmasterol promotes the reaction [GW 4064 results in increased expression of NR0B2 mRNA]

NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319

Nr1h4

nuclear receptor subfamily 1, group H, member 4

multiple interactions
affects response to substance
decreases expression

[bisphenol A co-treated with Stigmasterol] results in decreased expression of NR1H4 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of ANKRD1 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of BRINP3 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of HOXA5 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of MYBPC2 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of ZBTB16 mRNA]
Stigmasterol results in decreased expression of NR1H4 mRNA

NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056

Ptgs2

prostaglandin-endoperoxide synthase 2

multiple interactions

Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

PMID:23535395

NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335

Rpl18a

ribosomal protein L18A

decreases expression

Stigmasterol results in decreased expression of RPL18A mRNA

NCBI chr16:20,293,277...20,295,283
Ensembl chr16:20,293,229...20,295,294

Rpl31

ribosomal protein L31

decreases expression

Stigmasterol results in decreased expression of RPL31 mRNA

NCBI chr 9:46,086,959...46,090,444
Ensembl chr 9:46,086,984...46,090,997

Rpl36

ribosomal protein L36

decreases expression

Stigmasterol results in decreased expression of RPL36 mRNA

NCBI chr 9:10,441,228...10,441,981
Ensembl chr 9:10,441,259...10,441,834

Rpph1

ribonuclease P RNA component H1

decreases expression

Stigmasterol results in decreased expression of RPPH1 mRNA

NCBI chr15:27,738,989...27,739,245
Ensembl chr15:27,738,972...27,739,269

Rps14

ribosomal protein S14

decreases expression

Stigmasterol results in decreased expression of RPS14 mRNA

NCBI chr18:56,042,532...56,047,316
Ensembl chr18:56,044,369...56,047,316

Rps27

ribosomal protein S27

decreases expression

Stigmasterol results in decreased expression of RPS27RT mRNA

NCBI chr 2:189,572,175...189,573,280
Ensembl chr 2:189,572,176...189,573,280

Rps7

ribosomal protein S7

decreases expression

Stigmasterol results in decreased expression of RPS7 mRNA

NCBI chr 6:47,899,525...47,904,389
Ensembl chr 6:47,899,525...47,904,437

Stra8

stimulated by retinoic acid 8

decreases expression
multiple interactions

Stigmasterol results in decreased expression of STRA8 mRNA
GW 4064 inhibits the reaction [Stigmasterol results in decreased expression of STRA8 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of STRA8 mRNA]

NCBI chr 4:62,447,724...62,474,802
Ensembl chr 4:62,457,694...62,473,360

Tm2d3

TM2 domain containing 3

decreases expression

Stigmasterol results in decreased expression of TM2D3 mRNA

NCBI chr 1:126,573,474...126,595,778
Ensembl chr 1:126,586,543...126,595,603

Tnf

tumor necrosis factor

increases secretion
multiple interactions

Stigmasterol results in increased secretion of TNF protein
Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:23454145 PMID:23535395

NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000

Zbtb16

zinc finger and BTB domain containing 16

multiple interactions
decreases expression

[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of ZBTB16 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of ZBTB16 mRNA]