stigmastane derivative - Ontology Report

[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA]

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

Abcg5

ATP binding cassette subfamily G member 5

multiple interactions
decreases expression

[Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG5 mRNA
Stigmasterol results in decreased expression of ABCG5 mRNA

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

Abcg8

ATP binding cassette subfamily G member 8

multiple interactions
decreases expression

[Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG8 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG8 mRNA
Stigmasterol results in decreased expression of ABCG8 mRNA

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

Acat1

acetyl-CoA acetyltransferase 1

multiple interactions

[Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ACAT1 mRNA

NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855

Ankrd1

ankyrin repeat domain 1

multiple interactions

[NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

Apoa1

apolipoprotein A1

multiple interactions

[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA]; Stigmasterol promotes the reaction [GW 4064 results in increased expression of APOA1 mRNA]

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

Brinp3

BMP/retinoic acid inducible neural specific 3

multiple interactions

[NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of BRINP3 mRNA

NCBI chr13:58,413,883...58,846,828
Ensembl chr13:58,413,883...58,846,770

Cldn11

claudin 11

multiple interactions

[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA]

NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050

Dnmt3l

DNA methyltransferase 3 like

multiple interactions

[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA]

NCBI chr20:10,614,933...10,629,516
Ensembl chr20:10,614,934...10,629,516

Esr1

estrogen receptor 1

multiple interactions

[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

Fshr

follicle stimulating hormone receptor

multiple interactions

Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of FSHR mRNA]

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

Gabarap

GABA type A receptor-associated protein

decreases expression

Stigmasterol results in decreased expression of GABARAP mRNA

NCBI chr10:54,714,834...54,717,769
Ensembl chr10:54,714,198...54,717,765

Gfra1

GDNF family receptor alpha 1

multiple interactions

[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of GFRA1 mRNA]

NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473

Hmgcr

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
increases expression

[Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of HMGCR mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA
Stigmasterol results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

Hoxa5

homeo box A5

multiple interactions

[NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of HOXA5 mRNA

NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234

Ifi35

interferon-induced protein 35

decreases expression

Stigmasterol results in decreased expression of IFI35 mRNA

NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952

Il10

interleukin 10

increases secretion

Stigmasterol results in increased secretion of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

Il6

interleukin 6

multiple interactions

Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]

PMID:23535395

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Kng2

kininogen 2

multiple interactions

[Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of NPC1L1 mRNA

NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971

Mybpc2

myosin binding protein C2

multiple interactions

[NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of MYBPC2 mRNA

NCBI chr 1:94,994,104...95,017,650
Ensembl chr 1:94,994,104...95,017,584

Nanog

Nanog homeobox

decreases expression
multiple interactions

Stigmasterol results in decreased expression of NANOG mRNA
[bisphenol A co-treated with Stigmasterol] results in decreased expression of NANOG mRNA; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NANOG mRNA]

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

Nos2

nitric oxide synthase 2

multiple interactions

Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:23535395

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

Npc1l1

NPC1 like intracellular cholesterol transporter 1

multiple interactions

[Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of NPC1L1 mRNA; [Stigmasterol co-treated with Rotenone] results in increased expression of NPC1L1 mRNA

NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113

Nr0b1

nuclear receptor subfamily 0, group B, member 1

multiple interactions
decreases expression

[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA; GW 4064 promotes the reaction [Stigmasterol results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of NR0B1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NR0B1 mRNA]

NCBI chr X:50,756,886...50,761,014
Ensembl chr X:50,756,886...50,761,011

Nr0b2

nuclear receptor subfamily 0, group B, member 2

multiple interactions

Stigmasterol promotes the reaction [GW 4064 results in increased expression of NR0B2 mRNA]

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

Nr1h4

nuclear receptor subfamily 1, group H, member 4

multiple interactions
affects response to substance
decreases expression

[bisphenol A co-treated with Stigmasterol] results in decreased expression of NR1H4 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of ANKRD1 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of BRINP3 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of HOXA5 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of MYBPC2 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of ZBTB16 mRNA]
Stigmasterol results in decreased expression of NR1H4 mRNA

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

Ptgs2

prostaglandin-endoperoxide synthase 2

multiple interactions

Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

PMID:23535395

NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188

Rpl18a

ribosomal protein L18A

decreases expression

Stigmasterol results in decreased expression of RPL18A mRNA

NCBI chr16:18,542,572...18,544,578
Ensembl chr16:18,542,566...18,545,546

Rpl31

ribosomal protein L31

decreases expression

Stigmasterol results in decreased expression of RPL31 mRNA

NCBI chr 9:41,647,401...41,650,886
Ensembl chr 9:41,647,426...41,662,129

Rpl36

ribosomal protein L36

decreases expression

Stigmasterol results in decreased expression of RPL36 mRNA

NCBI chr 9:1,441,986...1,447,397
Ensembl chr 6:98,809,534...98,809,897

Rpph1

ribonuclease P RNA component H1

decreases expression

Stigmasterol results in decreased expression of RPPH1 mRNA

NCBI chr15:24,033,679...24,033,935
Ensembl chr15:24,033,662...24,033,959

Rps14

ribosomal protein S14

decreases expression

Stigmasterol results in decreased expression of RPS14 mRNA

NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166

Rps27

ribosomal protein S27

decreases expression

Stigmasterol results in decreased expression of RPS27RT mRNA

NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964

Rps7

ribosomal protein S7

decreases expression

Stigmasterol results in decreased expression of RPS7 mRNA

NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145

Stra8

stimulated by retinoic acid 8

decreases expression
multiple interactions

Stigmasterol results in decreased expression of STRA8 mRNA
GW 4064 inhibits the reaction [Stigmasterol results in decreased expression of STRA8 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of STRA8 mRNA]

NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771

Tm2d3

TM2 domain containing 3

decreases expression

Stigmasterol results in decreased expression of TM2D3 mRNA

NCBI chr 1:119,264,576...119,277,099
Ensembl chr 1:119,264,576...119,277,099

Tnf

tumor necrosis factor

increases secretion
multiple interactions

Stigmasterol results in increased secretion of TNF protein
Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:23454145 PMID:23535395

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Zbtb16

zinc finger and BTB domain containing 16

multiple interactions
decreases expression

[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of ZBTB16 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of ZBTB16 mRNA]