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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Mycoplasma genitalium metabolite
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Accession:CHEBI:131604 term browser browse the term
Definition:Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium.
Synonyms:related_synonym: Mycoplasma genitalium metabolites

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arecoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FN1 fibronectin 1 multiple interactions
increases expression		 EXP pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of FN1 protein] CTD PMID:26908192 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014 		JBrowse link
G SERPINE1 serpin family E member 1 increases expression
multiple interactions		 EXP Arecoline results in increased expression of SERPINE1 protein
pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of SERPINE1 protein]		 CTD PMID:26908192 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,564 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
increases expression		 EXP Arecoline results in increased secretion of and results in increased activity of TGFB1 protein; pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of TGFB1 mRNA] CTD PMID:26908192 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048 		JBrowse link
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis		 EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510 		JBrowse link
bucladesine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Bucladesine results in increased expression of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,606 		JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions		 EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]		 CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP Eplerenone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183 		JBrowse link
gabapentin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 affects binding EXP Gabapentin binds to CACNA2D1 protein CTD PMID:11687876 NCBI chr 9:97,781,057...98,265,925
Ensembl chr 9:97,780,742...98,266,573 		JBrowse link
KT 5823 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL4A2 collagen type IV alpha 2 chain multiple interactions
decreases expression		 EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A2 protein]
KT 5823 results in decreased expression of COL4A2 protein		 CTD PMID:21307347 NCBI chr11:76,996,885...77,161,617
Ensembl chr11:76,997,516...77,161,615 		JBrowse link
G COL4A3 collagen type IV alpha 3 chain decreases expression
multiple interactions		 EXP KT 5823 results in decreased expression of COL4A3 mRNA
KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A3 mRNA]		 CTD PMID:21307347 NCBI chr15:128,611,640...128,763,331
Ensembl chr15:128,611,866...128,763,122 		JBrowse link
G ITGAV integrin subunit alpha V multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,840 		JBrowse link
G ITGB3 integrin subunit beta 3 multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,505...16,752,292 		JBrowse link
nifedipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 family 3 subfamily A member 29 multiple interactions
increases oxidation		 EXP Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine]; Troleandomycin inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121 JBrowse link
S-adenosyl-L-methionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase multiple interactions EXP [S-Adenosylmethionine analog co-treated with COMT protein] results in increased methylation of catechol CTD PMID:20196537 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998 		JBrowse link
simvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression		 EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of HMGCR mRNA]
Simvastatin results in decreased expression of HMGCR mRNA		 CTD PMID:17130282 PMID:19343539 NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,225...84,402,956 		JBrowse link
G LDLR low density lipoprotein receptor multiple interactions
increases expression		 EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of LDLR mRNA]
Simvastatin results in increased expression of LDLR mRNA		 CTD PMID:17130282 NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,823 		JBrowse link
G NPC1L1 NPC1 like intracellular cholesterol transporter 1 multiple interactions EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of NPC1L1 mRNA] CTD PMID:17130282 NCBI chr18:50,726,854...50,757,676
Ensembl chr18:50,726,894...50,757,649 		JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 decreases expression EXP Simvastatin results in decreased expression of NR4A3 mRNA CTD PMID:16005304 NCBI chr 1:241,569,867...241,611,735
Ensembl chr 1:241,569,905...241,611,734 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Ezetimibe co-treated with Simvastatin] results in increased expression of SREBF1 mRNA CTD PMID:17130282 NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,265 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of SREBF2 mRNA] CTD PMID:17130282 NCBI chr 5:6,719,484...6,784,724
Ensembl chr 5:6,719,487...6,784,672 		JBrowse link
thapsigargin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP90B1 heat shock protein 90 beta family member 1 increases expression
multiple interactions
decreases expression
increases cleavage		 EXP Thapsigargin results in increased expression of HSP90B1 protein
PD 150606 inhibits the reaction [Thapsigargin results in increased cleavage of HSP90B1 protein]
Thapsigargin results in decreased expression of HSP90B1 protein		 CTD PMID:16759985 PMID:16920763 PMID:17416481 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Thapsigargin results in increased expression of HSPA5 protein CTD PMID:16759985 PMID:16920763 PMID:17416481 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 880
    role 860
      biological role 860
        biochemical role 729
          metabolite 717
            prokaryotic metabolite 319
              bacterial metabolite 319
                Mycoplasma genitalium metabolite 22
                  1,2-di-[(11Z)-octadecenoyl]glycerol 0
                  1,2-di-[(9Z)-hexadecenoyl]glycerol 0
                  1,2-dibutyrin 0
                  1,2-didodecanoyl-sn-glycero-3-cytidine 5'-diphosphate 0
                  1,2-dihexadec-9-enoyl-sn-glycero-3-cytidine 5'-diphosphate 0
                  1,2-dioctadec-11-enoyl-sn-glycero-3-cytidine 5'-diphosphate 0
                  1,2-dioctadecanoyl-sn-glycero-3-cytidine 5'-diphosphate 0
                  1,2-ditetradec-7-enoyl-sn-glycero-3-cytidine 5'-diphosphate 0
                  1,2-ditetradecanoyl-sn-glycero-3-cytidine 5'-diphosphate 0
                  1,3'-bis(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-5-amino-5-methyl-6-\{2-oxo-1,3-diazabicyclo[2.2.0]hex-4-en-6-yl\}-1,3-diazinane-2,4-dione 0
                  1,3'-bis(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-6-(5,6-diamino-2-oxo-2,3,4,5-tetrahydropyrimidin-4-yl)-1,3-diazabicyclo[2.2.0]hex-4-en-2-one 0
                  1,3'-bis(2-deoxy-beta-D-erythro-pentofuranosyl)-5-amino-5-methyl-6-\{2-oxo-1,3-diazabicyclo[2.2.0]hex-4-en-6-yl\}-1,3-diazinane-2,4-dione 0
                  1,3'-bis(2-deoxy-beta-D-erythro-pentofuranosyl)-6-(5,6-diamino-2-oxo-2,3,4,5-tetrahydropyrimidin-4-yl)-1,3-diazabicyclo[2.2.0]hex-4-en-2-one 0
                  1-myristoyl-2-oleoylglycerol + 0
                  2',3'-cyclic CMP 0
                  2'-deoxy-5,6-dihydroxy-5,6-dihydrocytidine 0
                  2'-deoxy-5,6-dihydroxy-5,6-dihydrocytidine 5'-monophosphate 0
                  2'-deoxy-5-(4,5-dihydroxypentyl)uridine 0
                  2'-deoxy-5-(4,5-dihydroxypentyl)uridine 5'-monophosphate 0
                  2'-deoxycytidine 5'-monophosphate dimer 0
                  2'-deoxycytidine dimer 0
                  2'-deoxycytidine-thymidine dimer 0
                  2'-deoxyinosine-5'-monophosphate 0
                  2,3-dideoxy-beta-D-ribose 5-phosphate 0
                  2,3-dipalmitoyl-S-glycerylcysteine 0
                  2-deoxy-D-glucose 6-phosphate 0
                  2-phenylpropan-2-ol 0
                  3'-(N-formyl-L-methionyl)-AMP 0
                  3'-L-alanyl-AMP 0
                  3'-L-arginyl-AMP 0
                  3'-L-asparaginyl-AMP 0
                  3'-L-aspartyl-AMP 0
                  3'-L-cysteinyl-AMP 0
                  3'-L-glutaminyl-AMP 0
                  3'-L-glutamyl-AMP 0
                  3'-L-histidyl-AMP 0
                  3'-L-isoleucyl-AMP 0
                  3'-L-leucyl-AMP 0
                  3'-L-lysyl-AMP 0
                  3'-L-methionyl-AMP 0
                  3'-L-phenylalanyl-AMP 0
                  3'-L-prolyl-AMP 0
                  3'-L-seryl-AMP 0
                  3'-L-threonyl-AMP 0
                  3'-L-tryptophyl-AMP 0
                  3'-L-tyrosyl-AMP 0
                  3'-L-valyl-AMP 0
                  3'-glycyl-AMP 0
                  4,5-diamino-1,2,4a,4b,7,8,8a,8b-octahydro-1,3,6,8-tetraazabiphenylene-2,7-dione 0
                  4-(5,6-diamino-2-oxo-2,3,4,5-tetrahydropyrimidin-4-yl)-1,2-dihydropyrimidin-2-one 0
                  4-amino-5-hydroxy-6-(5-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2,5-dihydropyrimidin-2-one 0
                  4a,4b-dimethylhexahydro-1,3,6,8-tetraazabiphenylene-2,4,5,7-tetrone 0
                  5',6'-diamino-1,3'-bis(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-4',5'-dihydro[4,4'-bipyrimidine]-2,2'(1H,3'H)-dione 0
                  5',6'-diamino-1,3'-bis(2-deoxy-beta-D-erythro-pentofuranosyl)-4',5'-dihydro[4,4'-bipyrimidine]-2,2'(1H,3'H)-dione 0
                  5'-d(pGpG)-3' + 0
                  5,6-dihydrothymidine 0
                  5,6-dihydrothymidine 5'-monophosphate 0
                  5,6-dihydroxy-2'-deoxyuridine 0
                  5,6-dihydroxy-2'-deoxyuridine 5'-monophosphate 0
                  5,6-dihydroxyuracil 0
                  5-(4,5-dihydroxypentyl)uracil 0
                  5-O-phosphono-2-deoxyribosyl-(3->5)-2,3-dideoxyribose 0
                  5-O-phosphono-2-deoxyribosyl-(3->5)-2-deoxyribose 0
                  5-amino-4a-methyl-1,2,3,4,4a,4b,7,8,8a,8b-decahydro-1,3,6,8-tetraazabiphenylene-2,4,7-trione 0
                  5-amino-5-methyl-6-\{2-oxo-1,3-diazabicyclo[2.2.0]hex-4-en-6-yl\}-1,3-diazinane-2,4-dione 0
                  5-carboxy-2'-deoxyuridine 0
                  5-carboxy-2'-deoxyuridine 5'-monophosphate 0
                  5-carboxymethylaminomethyl-2-thiouridine 0
                  5-carboxymethylaminomethyl-2-thiouridine 5'-monophosphate 0
                  6'-amino-1,3'-bis(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-5'-hydroxy-5-methyl-3,4-dihydro[4,4'-bipyrimidine]-2,2'(1H,3'H)-dione 0
                  6'-amino-1,3'-bis(2-deoxy-beta-D-erythro-pentofuranosyl)-5'-hydroxy-5-methyl-3,4-dihydro[4,4'-bipyrimidine]-2,2'(1H,3'H)-dione 0
                  6-(5,6-diamino-2-oxo-2,3,4,5-tetrahydropyrimidin-4-yl)-1,3-diazabicyclo[2.2.0]hex-4-en-2-one 0
                  6-azathymidine 0
                  6-azathymidine 5'-monophosphate 0
                  6-azathymine + 0
                  8,5'-cyclo-2'-deoxyadenosine 0
                  8,5'-cyclo-2'-deoxyadenosine monophosphate 0
                  8,5'-cyclo-2'-deoxyguanosine 0
                  8,5'-cyclo-2'-deoxyguanosine monophosphate 0
                  8-aza-2'-deoxyadenosine 5'-monophosphate 0
                  8-azaadenine + 0
                  Arg-Arg 0
                  Asn-Asn 0
                  Asp-Asp 0
                  CDP-dipalmitoyl-sn-glycerol 0
                  Cys-Cys 0
                  Gln-Gln 0
                  Glu-Glu + 0
                  His-His 0
                  Ile-Ile 0
                  L-alanyl-L-alanine 0
                  Leu-Leu 0
                  Lys-Lys 0
                  Met-Met + 0
                  N(6)-(5'-adenylyl)-L-lysine 0
                  N(6)-carbamoylmethyl-2'-deoxyadenosine 0
                  N(6)-carbamoylmethyl-2'-deoxyadenosine 5'-monophosphate 0
                  N(6)-carbamoylmethyladenine 0
                  N-(5'-adenylyl)morpholine 0
                  N-formyl-L-methionyl-L-methionine 0
                  N-hexadecanoylsphingosine 0
                  Phe-Phe 0
                  Pro-Pro 0
                  S-adenosyl-L-methionine + 1
                  Ser-Ser 0
                  Thr-Thr 0
                  Trp-Trp 0
                  Tyr-Tyr 0
                  Val-Val 0
                  adenosine 5'-phosphoramidate 0
                  butyric acid + 10
                  chloramphenicol + 0
                  cumene hydroperoxide 0
                  cyclic di-AMP 0
                  dAp-dAp 0
                  dCDP 0
                  dCMP-dTMP 0
                  difloxacin 0
                  dpC-dpC 0
                  menaquinone-7 0
                  methanol + 11
                  pApA 0
                  pCpC 0
                  pristinamycin IIA + 0
                  tetrahexadec-9-enoyl cardiolipin 0
                  tetrahexadecanoyl cardiolipin 0
                  tetraoctadec-11-enoyl cardiolipin 0
                  thymidine 5'-monophosphate dimer 0
                  thymidine dimer 0
paths to the root