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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:C18-steroid
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Accession:CHEBI:131591 term browser browse the term
Definition:A steroid compound with a structure based on a 18-carbon (estrane) skeleton.
Synonyms:related_synonym: C18-steroids


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trenbolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions
affects expression
increases expression		 EXP Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]; Flutamide inhibits the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]; fulvestrant inhibits the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]; trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]]
Trenbolone Acetate analog affects the expression of APP protein modified form		 CTD PMID:25461682 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions
affects binding
increases activity		 ISO
EXP		 Trenbolone Acetate binds to and results in increased activity of AR protein; Trenbolone Acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; triclocarban promotes the reaction [Trenbolone Acetate results in increased activity of AR protein]
Trenbolone Acetate binds to AR protein		 CTD PMID:14565775 PMID:16818248 PMID:18324785 PMID:20371976 PMID:20821581 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]; Flutamide promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]; fulvestrant affects the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]; Testosterone promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]; trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]] CTD PMID:25461682 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Trenbolone Acetate binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Trenbolone Acetate binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Trenbolone Acetate results in increased expression of ODC1 mRNA CTD PMID:17688994 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Psen1 presenilin 1 multiple interactions
decreases expression		 EXP Flutamide inhibits the reaction [Trenbolone Acetate analog results in decreased expression of PSEN1 protein]; fulvestrant inhibits the reaction [Trenbolone Acetate analog results in decreased expression of PSEN1 protein]; Testosterone affects the reaction [Trenbolone Acetate analog results in decreased expression of PSEN1 protein]; Trenbolone Acetate analog inhibits the reaction [Dihydrotestosterone results in increased expression of PSEN1 protein]; trilostane inhibits the reaction [Trenbolone Acetate analog inhibits the reaction [Dihydrotestosterone results in increased expression of PSEN1 protein]] CTD PMID:25461682 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Trenbolone Acetate binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    chemical entity 19930
      atom 19930
        nonmetal atom 19859
          carbon atom 19812
            organic molecular entity 19812
              lipid 18000
                steroid 14723
                  C18-steroid 8
                    17beta-hydroxy-5alpha-estr-1(10)-en-3-one 0
                    trenbolone 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                organic polycyclic compound 17274
                                  steroid 14723
                                    steroid fundamental parent 14518
                                      estrane 12498
                                        C18-steroid 8
                                          17beta-hydroxy-5alpha-estr-1(10)-en-3-one 0
                                          trenbolone 8
paths to the root