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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hyaluronic acid synthesis inhibitor
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Accession:CHEBI:131561 term browser browse the term
Definition:Any compound that inhibits one or more steps in the pathway leading to the synthesis of hyaluronic acid.
Synonyms:related_synonym: HA inhibitor;   HA inhibitors;   HA synthesis inhibitor;   HA synthesis inhibitors;   hyaluronic acid inhibitor;   hyaluronic acid inhibitors;   hyaluronic acid synthesis inhibitors

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4-methylumbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) affects export ISO ABCG2 protein affects the export of Hymecromone analog CTD PMID:15598971 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G CAT catalase multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 increases sulfation EXP
ISO		 SULT1A1 protein results in increased sulfation of Hymecromone CTD PMID:11181495 NCBI chr16:28,605,587...28,623,395
Ensembl chr16:28,605,196...28,623,625
Ensembl chr16:28,605,196...28,623,625 		JBrowse link
G SULT1D1P sulfotransferase family 1D member 1, pseudogene increases sulfation ISO SULT1A1 protein results in increased sulfation of Hymecromone CTD PMID:11181495 NCBI chr 4:69,791,873...69,813,872
Ensembl chr 4:69,791,872...69,813,888 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases metabolic processing
increases activity
increases glucuronidation		 EXP [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Estradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:15378558 PMID:15593333 PMID:15802387 PMID:26875642 PMID:31812603 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation
multiple interactions
increases activity		 EXP UGT1A10 protein results in increased glucuronidation of Hymecromone
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A10 protein]		 CTD PMID:15802387 PMID:22265884 PMID:25393417 PMID:26875642 NCBI chr 2:233,636,477...233,773,305
Ensembl chr 2:233,636,454...233,773,305 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases glucuronidation
increases metabolic processing
multiple interactions
increases activity		 EXP UGT1A3 protein results in increased glucuronidation of Hymecromone
UGT1A3 protein results in increased metabolism of Hymecromone
[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:15802387 PMID:26875642 PMID:31812603 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,108...233,773,299 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
increases metabolic processing
affects metabolic processing
increases activity
increases glucuronidation		 EXP
ISO		 [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
UGT1A6 gene polymorphism affects the metabolism of Hymecromone		 CTD PMID:9429234 PMID:15802387 PMID:18214896 PMID:25393417 PMID:26875642 PMID:31812603 NCBI chr 2:233,691,670...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation
multiple interactions
increases activity		 EXP UGT1A7 protein results in increased glucuronidation of Hymecromone
[Warfarin binds to and affects the activity of UGT1A7 protein] which affects the glucuronidation of Hymecromone; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A7 protein]; Warfarin affects the reaction [UGT1A7 protein results in increased glucuronidation of Hymecromone]		 CTD PMID:15802387 PMID:25393417 PMID:26875642 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,938...233,773,299 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 multiple interactions
increases metabolic processing
increases glucuronidation
increases activity		 EXP
ISO		 [UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A8 protein]; Propofol promotes the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]; pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:15378558 PMID:15502008 PMID:15802387 PMID:26875642 PMID:31812603 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,645...233,773,310 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
increases metabolic processing
increases activity
multiple interactions		 EXP UGT1A9 protein results in increased glucuronidation of Hymecromone
UGT1A9 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A9 protein
[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:15378558 PMID:15802387 PMID:26875642 PMID:31812603 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus increases glucuronidation EXP UGT2A1 protein results in increased glucuronidation of Hymecromone CTD PMID:21164388 NCBI chr 4:69,588,417...69,653,247
Ensembl chr 4:69,588,417...69,653,249 		JBrowse link
G UGT2B11 UDP glucuronosyltransferase family 2 member B11 increases glucuronidation EXP UGT2B11 protein results in increased glucuronidation of Hymecromone CTD PMID:8333863 NCBI chr 4:69,199,951...69,224,980
Ensembl chr 4:69,199,951...69,214,748 		JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing
multiple interactions
increases activity		 EXP UGT2B15 protein results in increased metabolism of Hymecromone; UGT2B15 protein SNP results in increased metabolism of Hymecromone
[UGT2B15 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B15 protein]; pterostilbene inhibits the reaction [[UGT2B15 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:7835232 PMID:12386133 PMID:26875642 PMID:31812603 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 increases metabolic processing
increases glucuronidation
multiple interactions
increases activity		 EXP
ISO		 UGT2B17 protein results in increased metabolism of Hymecromone
UGT2B1 protein results in increased glucuronidation of Hymecromone
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B17 protein]		 CTD PMID:8302279 PMID:8798464 PMID:26875642 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,184...68,568,527 		JBrowse link
G UGT2B4 UDP glucuronosyltransferase family 2 member B4 multiple interactions
increases metabolic processing
increases activity		 EXP [UGT2B4 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B4 protein]; pterostilbene inhibits the reaction [[UGT2B4 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:26875642 PMID:31812603 NCBI chr 4:69,480,165...69,526,014
Ensembl chr 4:69,480,165...69,526,014 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 increases activity
increases metabolic processing
multiple interactions		 EXP Hymecromone results in increased activity of UGT2B7 protein
UGT2B7 protein results in increased metabolism of Hymecromone
[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:26875642 PMID:31812603 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
4-methylumbelliferone beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 multiple interactions EXP [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,108...233,773,299 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 multiple interactions EXP [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 2:233,691,670...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 multiple interactions EXP [UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,645...233,773,310 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 multiple interactions EXP [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 multiple interactions EXP [UGT2B15 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT2B15 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652 		JBrowse link
G UGT2B4 UDP glucuronosyltransferase family 2 member B4 multiple interactions EXP [UGT2B4 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT2B4 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 4:69,480,165...69,526,014
Ensembl chr 4:69,480,165...69,526,014 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 multiple interactions EXP [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
4-methylumbelliferone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A11 solute carrier family 22 member 11 multiple interactions EXP 4-methylumbelliferyl sulfate inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate] CTD PMID:10660625 NCBI chr11:64,555,847...64,572,875
Ensembl chr11:64,555,690...64,572,875 		JBrowse link
G SLC22A9 solute carrier family 22 member 9 multiple interactions ISO 4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate] CTD PMID:18441515 NCBI chr11:63,368,871...63,410,878
Ensembl chr11:63,369,785...63,410,294 		JBrowse link
4-methylumbelliferyl beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CA12 carbonic anhydrase 12 decreases activity EXP 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA12 protein CTD PMID:22077347 NCBI chr15:63,321,378...63,381,846
Ensembl chr15:63,321,378...63,381,846 		JBrowse link
G CA9 carbonic anhydrase 9 decreases activity EXP 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA9 protein CTD PMID:22077347 NCBI chr 9:35,673,809...35,681,159
Ensembl chr 9:35,673,918...35,681,159 		JBrowse link
4-methylumbelliferyl beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GAA alpha glucosidase multiple interactions
increases metabolic processing		 EXP GAA gene SNP inhibits the reaction [GAA protein results in increased metabolism of 4-methylumbelliferyl glucoside] CTD PMID:21963784 NCBI chr17:80,101,535...80,119,881
Ensembl chr17:80,101,556...80,119,881 		JBrowse link
coumaphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) decreases activity EXP Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G GPAT3 glycerol-3-phosphate acyltransferase 3 increases expression EXP Coumaphos results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr 4:83,535,634...83,605,875
Ensembl chr 4:83,535,914...83,605,875 		JBrowse link
G LIF LIF interleukin 6 family cytokine increases expression EXP Coumaphos results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr22:30,240,453...30,257,487
Ensembl chr22:30,240,453...30,246,759 		JBrowse link
G RARA retinoic acid receptor alpha increases activity EXP Coumaphos results in increased activity of RARA protein CTD PMID:20143881 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression EXP Coumaphos results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24371
    role 24282
      biological role 24249
        inhibitor 21466
          hyaluronic acid synthesis inhibitor 29
            4-methylumbelliferone + 29
paths to the root