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Accession:CHEBI:131518 term browser browse the term
Definition:A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney.
Synonyms:exact_synonym: N,N-bis(2-hydroxypropyl)nitrous amide
 related_synonym: 2,2'-bishydroxypropylnitrosamine;   2,2'-dihydroxy-di-n-propylnitrosoamine;   DHPN;   Formula=C6H14N2O3;   InChI=1S/C6H14N2O3/c1-5(9)3-8(7-11)4-6(2)10/h5-6,9-10H,3-4H2,1-2H3;   InChIKey=MNIGYIKCFSPQRJ-UHFFFAOYSA-N;   N,N-di-(2-hydroxypropyl)nitrosamine;   N-bis(2-hydroxypropyl)nitrosamine;   N-nitroso-N,N-di(2-hydroxypropyl)amine;   N-nitrosobis(2-hydroxypropyl)amine;   N-nitrosodiisopropanolamine;   SMILES=CC(CN(CC(C)O)N=O)O;   di(2-hydroxypropyl)nitrosamine;   diisopropanolnitrosamine
 xref: CAS:53609-64-6 "ChemIDplus"
 xref_mesh: MESH:C012457
 xref: PMID:15201437 "Europe PMC";   PMID:15223773 "Europe PMC";   PMID:22634710 "Europe PMC";   PMID:24377951 "Europe PMC";   PMID:25024166 "Europe PMC";   PMID:6533030 "Europe PMC";   PMID:6533034 "Europe PMC";   PMID:728889 "Europe PMC";   Reaxys:2245909 "Reaxys"

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N,N-bis(2-hydroxypropyl)nitrosamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cp ceruloplasmin JBrowse link 2 104,744,249 104,803,034 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Tshb thyroid stimulating hormone subunit beta JBrowse link 2 205,207,799 205,215,199 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        aetiopathogenetic role 18754
          carcinogenic agent 17758
            N,N-bis(2-hydroxypropyl)nitrosamine 8
              N-nitrobis(2-hydroxypropyl)amine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      chalcogen 19224
                        oxygen atom 19179
                          oxygen molecular entity 19179
                            hydroxides 18960
                              organic hydroxy compound 18500
                                polyol 7568
                                  diol 2694
                                    N,N-bis(2-hydroxypropyl)nitrosamine 8
                                      N-nitrobis(2-hydroxypropyl)amine 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.