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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N,N-bis(2-hydroxypropyl)nitrosamine
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Accession:CHEBI:131518 term browser browse the term
Definition:A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney.
Synonyms:exact_synonym: N,N-bis(2-hydroxypropyl)nitrous amide
 related_synonym: 2,2'-bishydroxypropylnitrosamine;   2,2'-dihydroxy-di-n-propylnitrosoamine;   DHPN;   Formula=C6H14N2O3;   InChI=1S/C6H14N2O3/c1-5(9)3-8(7-11)4-6(2)10/h5-6,9-10H,3-4H2,1-2H3;   InChIKey=MNIGYIKCFSPQRJ-UHFFFAOYSA-N;   N,N-di-(2-hydroxypropyl)nitrosamine;   N-bis(2-hydroxypropyl)nitrosamine;   N-nitroso-N,N-di(2-hydroxypropyl)amine;   N-nitrosobis(2-hydroxypropyl)amine;   N-nitrosodiisopropanolamine;   SMILES=CC(CN(CC(C)O)N=O)O;   di(2-hydroxypropyl)nitrosamine;   diisopropanolnitrosamine
 xref: CAS:53609-64-6
 xref_mesh: MESH:C012457
 xref: PMID:15201437;   PMID:15223773;   PMID:22634710;   PMID:24377951;   PMID:25024166;   PMID:6533030;   PMID:6533034;   PMID:728889;   Reaxys:2245909



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N,N-bis(2-hydroxypropyl)nitrosamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cp ceruloplasmin multiple interactions EXP [diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of CP protein CTD PMID:19497425 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP [bisphenol A co-treated with diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of ESR1 protein; [bisphenol A co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 protein; [Potassium Iodide co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 protein CTD PMID:29050248 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Ifng interferon gamma multiple interactions EXP 2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein]; [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein CTD PMID:14736494 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il2 interleukin 2 multiple interactions EXP [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IL2 protein CTD PMID:14736494 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis EXP diisopropanolnitrosamine results in increased mutagenesis of KRAS gene CTD PMID:18271921 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP [diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of MKI67 protein; [Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein; Copper deficiency inhibits the reaction [[diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of MKI67 protein]; Copper inhibits the reaction [[diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of MKI67 protein]; Indomethacin inhibits the reaction [[Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein]; nimesulide inhibits the reaction [[Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein] CTD PMID:19497425 PMID:22387750 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Potassium Iodide co-treated with diisopropanolnitrosamine] results in increased expression of PCNA protein CTD PMID:29050248 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of TSHB protein CTD PMID:29050248 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link

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  CHEBI ontology 19808
    role 19757
      biological role 19757
        aetiopathogenetic role 19032
          carcinogenic agent 18359
            N,N-bis(2-hydroxypropyl)nitrosamine 8
              N-nitrobis(2-hydroxypropyl)amine 0
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Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      chalcogen 19456
                        oxygen atom 19432
                          oxygen molecular entity 19432
                            hydroxides 19171
                              organic hydroxy compound 18666
                                polyol 8081
                                  diol 3346
                                    N,N-bis(2-hydroxypropyl)nitrosamine 8
                                      N-nitrobis(2-hydroxypropyl)amine 0
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