Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N,N-bis(2-hydroxypropyl)nitrosamine
go back to main search page
Accession:CHEBI:131518 term browser browse the term
Definition:A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney.
Synonyms:exact_synonym: N,N-bis(2-hydroxypropyl)nitrous amide
 related_synonym: 2,2'-bishydroxypropylnitrosamine;   2,2'-dihydroxy-di-n-propylnitrosoamine;   DHPN;   Formula=C6H14N2O3;   InChI=1S/C6H14N2O3/c1-5(9)3-8(7-11)4-6(2)10/h5-6,9-10H,3-4H2,1-2H3;   InChIKey=MNIGYIKCFSPQRJ-UHFFFAOYSA-N;   N,N-di-(2-hydroxypropyl)nitrosamine;   N-bis(2-hydroxypropyl)nitrosamine;   N-nitroso-N,N-di(2-hydroxypropyl)amine;   N-nitrosobis(2-hydroxypropyl)amine;   N-nitrosodiisopropanolamine;   SMILES=CC(CN(CC(C)O)N=O)O;   di(2-hydroxypropyl)nitrosamine;   diisopropanolnitrosamine
 xref: CAS:53609-64-6
 xref_mesh: MESH:C012457
 xref: PMID:15201437;   PMID:15223773;   PMID:22634710;   PMID:24377951;   PMID:25024166;   PMID:6533030;   PMID:6533034;   PMID:728889;   Reaxys:2245909


show annotations for term's descendants           Sort by:
 
N,N-bis(2-hydroxypropyl)nitrosamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cp ceruloplasmin multiple interactions EXP [diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of CP protein CTD PMID:19497425 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP [bisphenol A co-treated with diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of ESR1 protein; [bisphenol A co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 protein; [Potassium Iodide co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 protein CTD PMID:29050248 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Ifng interferon gamma multiple interactions EXP 2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein]; [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein CTD PMID:14736494 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il2 interleukin 2 multiple interactions EXP [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IL2 protein CTD PMID:14736494 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis EXP diisopropanolnitrosamine results in increased mutagenesis of KRAS gene CTD PMID:18271921 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP [diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of MKI67 protein; [Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein; Copper deficiency inhibits the reaction [[diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of MKI67 protein]; Copper inhibits the reaction [[diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of MKI67 protein]; Indomethacin inhibits the reaction [[Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein]; nimesulide inhibits the reaction [[Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein] CTD PMID:19497425, PMID:22387750 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Potassium Iodide co-treated with diisopropanolnitrosamine] results in increased expression of PCNA protein CTD PMID:29050248 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of TSHB protein CTD PMID:29050248 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        aetiopathogenetic role 18937
          carcinogenic agent 18314
            N,N-bis(2-hydroxypropyl)nitrosamine 8
              N-nitrobis(2-hydroxypropyl)amine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      chalcogen 19362
                        oxygen atom 19323
                          oxygen molecular entity 19323
                            hydroxides 19068
                              organic hydroxy compound 18634
                                polyol 7802
                                  diol 2718
                                    N,N-bis(2-hydroxypropyl)nitrosamine 8
                                      N-nitrobis(2-hydroxypropyl)amine 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.